Hayward, Alex - University of Exeter - Disciplines of Biosciences

个人简介

2007 PhD University of Edinburgh 2001 MSc Imperial College, 2000 BSc University of Birmingham

研究领域

Evolutionary significance of transposable elements Since the onset of the genomics era, it has become apparent that transposons comprise large proportions of many eukaryote genomes, and have made great contributions to host genomic complexity. By harnessing the untapped potential of massive genomic datasets, we can now address fundamental unanswered questions relating to the significance of transposons, including: their impact on host evolution via contribution of coding and regulatory sequences, their influence on major evolutionary processes such as speciation, and the evolutionary dynamics that underpin transposon proliferation. Host-retrovirus coevolution Retroviruses have left a rich ‘genomic fossil record’ in vertebrate genomes in the form of endogenous retroviruses (ERVs). This represents a rare opportunity to explore host-pathogen interactions over evolutionary timescales. Key questions include examining the evolution of host generalism verses host specialism, identifying key determinants of infectivity, and resolving the early evolution of retroviruses. Determinants of parasite load The abundance and diversity of parasites that infect hosts often varies considerably, even among closely related host species. A major unanswered question concerns the role that host traits play in determining parasite load. Evolution and structure of ecological communities Ecological communities are complex entities that vary across time and space. The extent to which communities move and persist as single units, verses assembly via recruitment of members from disparate origins, represents an open question. Furthermore, the role played by lower trophic levels in structuring higher trophic levels remains unclear. Invertebrate developmental genomics Over 60% of described animal species undergo metamorphosis, many of which are invertebrate taxa. Yet, much remains to be understood regarding both the significance of metamorphosis and its molecular bases. Genomic methods present a powerful means of examining the evolution of invertebrate development more generally.

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Ács Z, Hayward A, Sugár L (2016). Genetic diversity and population genetics of large lungworms (Dictyocaulus, Nematoda) in wild deer in Hungary. Parasitol Res, 115(9), 3295-3312. Abstract. Author URL. Article has an altmetric score of 3 Mcmahon DP, Hayward A (2016). Why grow up? a perspective on insect strategies to avoid metamorphosis. Ecological Entomology, 41(5), 505-515. Abstract. Article has an altmetric score of 38 Tsuboi M, Husby A, Kotrschal A, Hayward A, Buechel SD, Zidar J, Løvlie H, Kolm N (2015). Comparative support for the expensive tissue hypothesis: Big brains are correlated with smaller gut and greater parental investment in Lake Tanganyika cichlids. Evolution, 69(1), 190-200. Article has an altmetric score of 7 Hayward A, Katzourakis A (2015). Endogenous retroviruses. Current Biology, 25(15), R644-R646. Article has an altmetric score of 15 Hayward A, Cornwallis CK, Jern P (2015). Pan-vertebrate comparative genomics unmasks retrovirus macroevolution. Proceedings of the National Academy of Sciences, 112(2), 464-469. Article has an altmetric score of 63 Kenny NJ, Sin YW, Hayward A, Paps J, Chu KH, Hui JHL (2015). The phylogenetic utility and functional constraint of microRNA flanking sequences. Proceedings of the Royal Society B: Biological Sciences, 282(1803), 20142983-20142983. Article has an altmetric score of 11 Erezyilmaz DF, Hayward A, Huang Y, Paps J, Acs Z, Delgado JA, Collantes F, Kathirithamby J (2014). Expression of the Pupal Determinant broad during Metamorphic and Neotenic Development of the Strepsipteran Xenos vesparum Rossi. PLoS ONE, 9(4), e93614-e93614. Hayward A, Grabherr M, Jern P (2013). Broad-scale phylogenomics provides insights into retrovirus-host evolution. Proceedings of the National Academy of Sciences, 110(50), 20146-20151. Article has an altmetric score of 114 Hayward A, Ghazal A, Andersson G, Andersson L, Jern P (2013). ZBED Evolution: Repeated Utilization of DNA Transposons as Regulators of Diverse Host Functions. PLoS ONE, 8(3), e59940-e59940. Article has an altmetric score of 1 Groenen MAM, Archibald AL, Uenishi H, Tuggle CK, Takeuchi Y, Rothschild MF, Rogel-Gaillard C, Park C, Milan D, Megens H-J, et al (2012). Analyses of pig genomes provide insight into porcine demography and evolution. Nature, 491(7424), 393-398. Article has an altmetric score of 332 HAYWARD ALEXANDER, MCMAHON DINOP, KATHIRITHAMBY JEYARANEY (2011). Cryptic diversity and female host specificity in a parasitoid where the sexes utilize hosts from separate orders. Molecular Ecology, 20(7), 1508-1528. Article has an altmetric score of 1 McMahon DP, Hayward A, Kathirithamby J (2011). Strepsiptera. Current Biology, 21(8), R271-R272. Article has an altmetric score of 1 McMahon DP, Hayward A, Kathirithamby J (2011). The First Molecular Phylogeny of Strepsiptera (Insecta) Reveals an Early Burst of Molecular Evolution Correlated with the Transition to Endoparasitism. PLoS ONE, 6(6), e21206-e21206. Article has an altmetric score of 3 Nicholls JA, Fuentes-Utrilla P, Hayward A, Melika G, Csóka G, Nieves-Aldrey JL, Pujade-Villar J, Tavakoli M, Schönrogge K, Stone GN, et al (2010). Community impacts of anthropogenic disturbance: natural enemies exploit multiple routes in pursuit of invading herbivore hosts. BMC Evol Biol, 10 Abstract. Author URL. Hayward A, Takahashi T, Bendena WG, Tobe SS, Hui JHL (2010). Comparative genomic and phylogenetic analysis of vitellogenin and other large lipid transfer proteins in metazoans. FEBS Letters, 584(6), 1273-1278. Nicholls JA, Preuss S, Hayward A, Melika G, Csóka G, Nieves-Aldrey JL, Askew RR, Tavakoli M, Schönrogge K, Stone GN, et al (2010). Concordant phylogeography and cryptic speciation in two Western Palaearctic oak gall parasitoid species complexes. Mol Ecol, 19(3), 592-609. Abstract. Author URL. KATHIRITHAMBY JEYARANEY, HAYWARD ALEXANDER, MCMAHON DINOP, FERREIRA RONARAS, ANDREAZZE RICARDO, ALMEIDA ANDRADE HERBETTADEUDE, FRESNEAU DOMINIQUE (2010). Conspecifics of a heterotrophic heteronomous species of Strepsiptera (Insecta) are matched by molecular characterization. Systematic Entomology, 35(2), 234-242. Article has an altmetric score of 1 HAYWARD ALEXANDER (2010). Cryptic diversity and patterns of host specificity in trematode flatworms. Molecular Ecology, 19(13), 2602-2604. Hui JHL, Hayward A, Bendena WG, Takahashi T, Tobe SS (2010). Evolution and functional divergence of enzymes involved in sesquiterpenoid hormone biosynthesis in crustaceans and insects. Peptides, 31(3), 451-455. Ács Z, Challis RJ, Bihari P, Blaxter M, Hayward A, Melika G, Csóka G, Pénzes Z, Pujade-Villar J, Nieves-Aldrey J-L, et al (2010). Phylogeny and DNA barcoding of inquiline oak gallwasps (Hymenoptera: Cynipidae) of the Western Palaearctic. Molecular Phylogenetics and Evolution, 55(1), 210-225.