Haynes, Ken - University of Exeter - Disciplines of Biosciences

个人简介

1987-1990 PhD Fungal Biology, University of London 1977-1980 BSc Microbiology, University of Bristol Career 2010-present Professor of Fungal Biology, Chair in Systems Biology, School of Biosciences, University of Exeter 2008-2010 Professor of Fungal Biology, Department of Microbiology, Imperial College London 2005-2008 Reader in Molecular Mycology, Department of Microbiology, Imperial College London 1999-2005 Senior Lecturer in Molecular Mycology, Department of Infectious Diseases & Microbiology, Imperial College London 1997-1999 Lecturer in Molecular Mycology, Department of Infectious Diseases & Microbiology, Imperial College London 1995-1997 Lecturer in Molecular Mycology, Department of Infectious Diseases, Royal Postgraduate Medical School, London 1990-1995 Lecturer in Mycology, Department of Medical Microbiology, Charing Cross & Westminster Medical School, London

研究领域

The Haynes group is interested in understanding the molecular basis of fungal virulence, utilising a functional genomics approach. Our research focuses on Candida glabrata a pathogen of humans; the wheat pathogen Mycosphaerella graminicola and the microsporidial pathogen of honey bees Nosema cerane. In addition we utilise model fungi in particular Saccharomyces cerevisiae to investigate basic processes (e.g. cell separation, stress adaptation and pH sensing) that can inform our virulence analyses. We are also part of the systems biology theme at Exeter and are collaborating with computer scientists, mathematicians and engineers to address problems in fungal pathogenicity.

近期论文

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Cairns TC, Studholme DJ, Talbot NJ, Haynes K (2016). New and Improved Techniques for the Study of Pathogenic Fungi. Trends in Microbiology, 24(1), 35-50. Abstract. Article has an altmetric score of 9 Sidhu YS, Chaudhari YK, Usher J, Cairns TC, Csukai M, Haynes K (2015). A suite of Gateway® compatible ternary expression vectors for functional analysis in Zymoseptoria tritici. Fungal Genet Biol, 79, 180-185. Abstract. Author URL. Article has an altmetric score of 4 Ho HL, Haynes K (2015). Candida glabrata: new tools and technologies-expanding the toolkit. FEMS Yeast Res, 15(6). Abstract. Author URL. Article has an altmetric score of 3 Marchegiani E, Sidhu Y, Haynes K, Lebrun MH (2015). Conditional gene expression and promoter replacement in Zymoseptoria tritici using fungal nitrate reductase promoters. Fungal Genet Biol, 79, 174-179. Abstract. Author URL. Article has an altmetric score of 3 Cairns TC, Sidhu YS, Chaudhari YK, Talbot NJ, Studholme DJ, Haynes K (2015). Construction and high-throughput phenotypic screening ofZymoseptoria tritici over-expression strains. Fungal Genet Biol, 79, 110-117. Abstract. Author URL. Article has an altmetric score of 2 Sidhu YS, Cairns TC, Chaudhari YK, Usher J, Talbot NJ, Studholme DJ, Csukai M, Haynes K (2015). Exploitation of sulfonylurea resistance marker and non-homologous end joining mutants for functional analysis in Zymoseptoria tritici. Fungal Genet Biol, 79, 102-109. Abstract. Author URL. Article has an altmetric score of 4 Komalapriya C, Kaloriti D, Tillmann AT, Yin Z, Herrero-de-Dios C, Jacobsen MD, Belmonte RC, Cameron G, Haynes K, Grebogi C, et al (2015). Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans. PLoS One, 10(9). Abstract. Author URL. Usher J, Thomas G, Haynes K (2015). Utilising established SDL-screening methods as a tool for the functional genomic characterisation of model and non-model organisms. FEMS Yeast Res, 15(8). Abstract. Author URL. Article has an altmetric score of 3 Usher J, Thomas G, Haynes K (2015). Utilising established SDL-screening methods as a tool for the functional genomic characterisation of modeland non-model organisms. FEMS Yeast Research, 15(8). Abstract. Barnes RA, Gow NAR, Denning DW, May RC, Haynes K (2014). Antifungal resistance: More research needed. The Lancet, 384(9952). Article has an altmetric score of 11 Holland LM, Schröder MS, Turner SA, Taff H, Andes D, Grózer Z, Gácser A, Ames L, Haynes K, Higgins DG, et al (2014). Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans. PLoS Pathog, 10(9). Abstract. Author URL. Article has an altmetric score of 4 Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, et al (2014). Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLoS One, 9(5). Abstract. Author URL. Full text. Kaloriti D, Jacobsen M, Yin Z, Patterson M, Tillmann A, Smith DA, Cook E, you T, Grimm MJ, Bohovych I, et al (2014). Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. MBio, 5(4), e01334-e01314. Abstract. Author URL. Article has an altmetric score of 2 Schwarzmüller T, Ma B, Hiller E, Istel F, Tscherner M, Brunke S, Ames L, Firon A, Green B, Cabral V, et al (2014). Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLoS Pathog, 10(6). Abstract. Author URL. Article has an altmetric score of 30 Ke R, Ingram PJ, Haynes K (2013). An integrative model of ion regulation in yeast. PLoS Comput Biol, 9(1). Abstract. Author URL. Article has an altmetric score of 1 West L, Lowman DW, Mora-Montes HM, Grubb S, Murdoch C, Thornhill MH, Gow NA, Williams D, Haynes K (2013). Differential virulence of Candida glabrata glycosylation mutants. J Biol Chem, 288(30), 22006-22018. Abstract. Author URL. Full text. Article has an altmetric score of 3 Ke R, Haynes K, Stark J (2013). Modelling the activation of alkaline pH response transcription factor PacC in Aspergillus nidulans: involvement of a negative feedback loop. J Theor Biol, 326, 11-20. Abstract. Author URL. Article has an altmetric score of 1 Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecology Letters, 16(10), 1267-1276. Abstract. Article has an altmetric score of 93 You T, Ingram P, Jacobsen MD, Cook E, McDonagh A, Thorne T, Lenardon MD, de Moura AP, Romano MC, Thiel M, et al (2012). A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi. BMC Res Notes, 5 Abstract. Author URL. Kaloriti D, Tillmann A, Cook E, Jacobsen M, you T, Lenardon M, Ames L, Barahona M, Chandrasekaran K, Coghill G, et al (2012). Combinatorial stresses kill pathogenic Candida species. Med Mycol, 50(7), 699-709. Abstract. Author URL.