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个人简介

1998-2002 吉林大学 学士 Jilin University B.S. 2002-2008 北京大学 博士 Peking University Ph.D 2008-2013 美国加州大学洛杉矶分校&霍华德休斯医学院 博士后 UCLA&HHMI Postdoc 2013.9-至今 中国科学院生物与化学交叉研究中心 研究员、课题组长

研究领域

1. 与神经退行性疾病如阿尔兹海默病、帕金森病, 渐冻人病相关的蛋白质的错误折叠,异常积聚,和淀粉样化的分子机理和结构基础研究。 2. 新颖的结构生物学方法的发展和运用,如蛋白质纳米级晶体的电子衍射技术,in-cell NMR技术等。并运用其系统研究淀粉样蛋白在体外及体内聚集的结构基础。 3. 基于多种神经退行性疾病的重要靶点分子结构信息的药物先导物的设计,筛选和优化。 4. 基于淀粉样多肽的具有新功能的新材料设计,开发和应用

近期论文

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Zhao Q.Y., Tao Y.Q., Zhao K., Ma Y.Y., Xu Q.H., Liu C., Zhang S.N., Li D.*; Structural insights of Fe 3+ induced α-synuclein fibrillation in Parkinson's disease. Journal of Molecular Biology, 2022. Wang L.Q., Ma Y.Y., Yuan H.Y., Zhao K., Zhang M.Y., Wang Q., Huang X., Dai B., Chen J., Li D., Zhang D.L., Wang Z.Z., Zou L.Y., Yin P., Liu C.*, Liang Y.*, Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion. Nature Communications, 2022, 13(1) Li D.*, Liu C.*, Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks. Trends in Cell Biology, 2021, 32(1). Fan Y., Zhao Q.Y., Xia W.C., Tao Y.Q., Yu W.B., Chen M.J., Liu Y.Q., Zhao J., Sun Y.P., Si, C.F., Zhang S.Q., Zhang Y.Y., Li W.S., Liu C.*, Wang J.*, Li D.*, Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders. Cell Research, 2022. Huang C.A., Lu J.X., Ma X.J., Qiang J.L., Wang C.C., Liu C., Fang Y.S., Zhang Y.Y., Li D.*, Zhang S.N.*, The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins. Journal of Biological Chemistry, 2022, 298(5). Li Y.C., Lu S.Y., Gu J.G., Xia W.C., Zhang S.N., Zhang S.Q., Wang Y., Zhang C., Sun Y.P., Lei J., Liu C., Su Z.M.*, Yang J.T.*, Peng X.Z.*, Li D.*, SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation. Protein Cell, 2022, 1-13. Li Y.C., Gu J.G., Liu C.*, Li D.*, A high-throughput method for exploring the parameter space of protein liquid-liquid phase separation. Cell Reports Physical Science, 2022. Zhu S.B., Gu J.G., Yao J.J., Li Y.C., Zhang Z.T., Xia W.C., Wang Z., Gui X.R., Li L.T., Li D., Zhang H.*, Liu C.*, Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis. Developmental Cell, 2022, 57(5). Song Y.X., Dai B., Wang Y., Wang Y., Liu C., Gourdon P., Liu L.*, Wang K.T.*, Dong M.D.*, Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation. Nano Letters, 2022, 22(9). Long H.F., Zeng S.Y., Sun Y.P., Liu C.*, Biochemical and biophysical characterization of pathological aggregation of amyloid proteins. Biophysics Reports, 2022, 8(1). Long H.F., Zeng S.Y., Li D.*, Cellular and animal models to investigate pathogenesis of amyloid aggregation in neurodegenerative diseases. Biophysics Reports, 2022, 8(1). Li, D.*, Liu, C.*, Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases. Nature Reviews Neuroscience, 2022. Li Y.C., Gu J.G., Wang C., Hu J.J., Zhang S.Q., Liu C., Zhang S.N., Fang Y.S., Li D.*, Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation. iScience, 2022, 25(6). Liu D.L., Wei Q.J., Xia W.C., He C.D., Zhang Q.K., Huang L., Wang X.Y., Sun Y.P., Ma Y.Y., Zhang X.H., Wang Y., Shi X.M., Liu C.*, Dong S.W.*, O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable for Degradation. J. Am. Chem. Soc., 2021, 143(48). Sun Y.P., Long H.F., Xia W.C., Wang K., Zhang X., Sun B., Cao Q., Zhang Y.Y., Dai B., Li D., Liu C.*, The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein. Nature Communications, 2021, 12(1). Wang L.Q., Zhao K., Yuan H.Y., Dang H.B., Ma Y.Y., Wang Q., Wang C., Sun Y.P., Chen J., Li D., Zhang D.L., Yin P., Liu C.*, Liang Y.*, Genetic prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM. Science Advances, 2021, 7(37). Sun Y.P., Zhang S.Q., Hu J.J., Tao Y.Q., Xia W.C., Gu J.G., Li Y.C., Cao Q., Li D., Liu C.*, Molecular structure of an amyloid fibril formed by FUS low-complexity domain. iScience, 2021, 25(1). Wu X.L., Ma Y.Y., Zhao K., Zhang J., Sun Y.P., Li Y.C., Dong X.Q., Hu H., Liu J., Wang J., Zhang X., Li B., Wang H.Y., Li D., Sun B., Lu J.X.*, Liu C.*, The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(14). Gu J.G., Wang C., Hu R.F., Li Y.C., Zhang S.N., Sun Y.P., Wang Q.Q., Li D., Fang Y.S.*, Liu C.*, Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation. Cell Research, 2021, 31(9). Zhang S.N., Liu Y.Q., Jia C.Y., Lim Y.J., Feng G.Q., Xu E.Q., Long, H.F., Yasuyoshi Kimura, Tao Y.Q., Zhao C.Y., Wang C.C., Liu Z.Y., Hu J.J., Ma M.R., Liu Z.J., Lin J., Li D., Wang R.X., Valina L Dawson, Ted M Dawson*, Li Y.M.*, Mao X.B.*, Liu C.*, Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America of the United States of America, 2021, 118(26).

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