Deeks, Mike - University of Exeter - Disciplines of Biosciences

个人简介

1998 - 2001 University of Leeds. PhD Genetics. 1995 - 1998 University of Leeds. B.Sc. Hons. Genetics. Career 7/98 - 9/98 Research Assistant, John Innes Institute, Norwich. 10/01 – 6/13 Senior Research Associate/Postdoctoral Fellow, School of Biological and Biomedical Sciences, Durham University. 7/13 - Lecturer in Plant Biology, Department of Biosciences, University of Exeter.

研究领域

Our research aims to understand the response of plant cells to localised pathogen assault. Changes in cell architecture support the plant immune system and an understanding of this response could potentially be exploited to protect key crops. We are investigating the mechanisms co-ordinating this spatially focused phenomenon using advanced light microscopy combined with a broad range of molecular, genetic and biochemical techniques. We are particularly interested in how the plant-pathogen interface emerges from the co-ordination of several processes: Microbe perception Cytoskeletal re-arrangement Long-range cargo transport Exocytosis (cargo delivery) Endocytosis (cargo recovery) We are developing bioimage informatics and modelling approaches to better understand the relationships between these different players in both model plants and key cereals.

近期论文

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Moger JJ, Littlejohn GL, Deeks MD (In Press). Making microscopy count: quantitative light microscopy of dynamic processes in living plants. Journal of Microscopy Abstract. Full text. Deeks M, Sánchez-Rodríguez C (2016). Seeing is believing: cell biology at the plant-microbe interface. New Phytol, 211(1), 16-19. Author URL. Full text. Article has an altmetric score of 46 Martin-Urdiroz M, Deeks MJ, Horton CG, Dawe HR, Jourdain I (2016). The Exocyst Complex in Health and Disease. Frontiers in Cell and Developmental Biology, 4 Full text. Article has an altmetric score of 8 Hawkins TJ, Deeks MJ, Wang P, Hussey PJ (2014). The evolution of the actin binding NET superfamily. Front Plant Sci, 5 Abstract. Author URL. Article has an altmetric score of 3 Wang P, Hawkins TJ, Richardson C, Cummins I, Deeks MJ, Sparkes I, Hawes C, Hussey PJ (2014). The plant cytoskeleton, NET3C, and VAP27 mediate the link between the plasma membrane and endoplasmic reticulum. Curr Biol, 24(12), 1397-1405. Abstract. Author URL. Full text. Article has an altmetric score of 1 Deeks MJ, Calcutt JR, Ingle EKS, Hawkins TJ, Chapman S, Richardson AC, Mentlak DA, Dixon MR, Cartwright F, Smertenko AP, et al (2012). A superfamily of actin-binding proteins at the actin-membrane nexus of higher plants. Current Biology, 22(17), 1595-1600. Abstract. Article has an altmetric score of 6 Tõth R, Gerding-Reimers C, Deeks MJ, Menninger S, Gallegos RM, Tonaco IAN, Hübel K, Hussey PJ, Waldmann H, Coupland G, et al (2012). Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana. Plant Journal, 71(2), 338-352. Abstract. Article has an altmetric score of 1 Jiang K, Sorefan K, Deeks MJ, Bevan MW, Hussey PJ, Hetherington AM (2012). The ARP2/3 complex mediates guard cell actin reorganization and stomatal movement in Arabidopsis. Plant Cell, 24(5), 2031-2040. Abstract. Liu J, Piette BMAG, Deeks MJ, Franklin-Tong VE, Hussey PJ (2010). A compartmental model analysis of integrative and self- regulatory ion dynamics in pollen tube growth. PLoS ONE, 5(10). Abstract. Article has an altmetric score of 1 Smertenko AP, Deeks MJ, Hussey PJ (2010). Strategies of actin reorganisation in plant cells. J Cell Sci, 123(Pt 17), 3019-3028. Abstract. Author URL. Deeks MJ, Fendrych M, Smertenko A, Bell KS, Oparka K, Cvrcková F, Zársky V, Hussey PJ (2010). The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain. J Cell Sci, 123(Pt 8), 1209-1215. Abstract. Author URL. Piette BM, Liu J, Peeters K, Smertenko A, Hawkins T, Deeks M, Quinlan R, Zakrzewski WJ, Hussey PJ (2009). A thermodynamic model of microtubule assembly and disassembly. PLoS One, 4(8). Abstract. Author URL. Article has an altmetric score of 2 Deeks MJ, Rodrigues C, Dimmock S, Ketelaar T, Maciver SK, Malhó R, Hussey PJ (2007). Arabidopsis CAP1 - a key regulator of actin organisation and development. J Cell Sci, 120(Pt 15), 2609-2618. Abstract. Author URL. Article has an altmetric score of 3 Uhrig JF, Mutondo M, Zimmermann I, Deeks MJ, Machesky LM, Thomas P, Uhrig S, Rambke C, Hussey PJ, Hülskamp M, et al (2007). The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis. Development, 134(5), 967-977. Abstract. Hussey PJ, Ketelaar T, Deeks MJ (2006). Control of the actin cytoskeleton in plant cell growth. Annual Review of Plant Biology, 57, 109-125. Abstract. Deeks MJ, Cvrcková F, Machesky LM, Mikitová V, Ketelaar T, Zársky V, Davies B, Hussey PJ (2005). Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression. New Phytologist, 168(3), 529-540. Abstract. Deeks MJ, Hussey PJ (2005). Arp2/3 and SCAR: Plants move to the fore. Nature Reviews Molecular Cell Biology, 6(12), 954-964. Abstract. Deeks MJ, Kaloriti D, Davies B, Malhó R, Hussey PJ (2004). Arabidopsis NAP1 is essential for Arp2/3-dependent trichome morphogenesis. Current Biology, 14(15), 1410-1414. Abstract. Deeks MJ, Hussey PJ (2003). Arp2/3 and 'The Shape of things to come'. Current Opinion in Plant Biology, 6(6), 561-567. Abstract. Deeks MJ, Hussey PJ, Davies B (2002). Formins: Intermediates in signal-transduction cascades that affect cytoskeletal reorganization. Trends in Plant Science, 7(11), 492-498. Abstract.