Dawe, Helen - University of Exeter - Disciplines of Biosciences

个人简介

1999-2003 PhD Molecular Cell Biology, MRC Laboratory for Molecular Cell Biology, University of London 1995-1999 BSc (Hons) Biochemistry with Industrial Experience, University of Manchester Career 2009-present Lecturer in Cell Biology, University of Exeter 2008-2009 University Research Lecturer, University of Oxford 2006-2009 Beit Memorial Fellow, University of Oxford, and Fellow of Brasenose College Oxford 2003-2006 Postdoctoral Research Associate, University of Oxford

研究领域

Eukaryotic cilia and flagella are remarkably conserved, both at the structural and functional levels, from evolutionarily ancient unicellular eukaryotes to man and are adapted to carry out diverse roles. Almost every cell in the human body can form a cilium or flagellum, either motile or non-motile. Motile cilia move fluids past epithelial cell layers in multicellular organisms; however, non-motile primary cilia are the most common type of cilia in the body. The roles of primary cilia were unclear but the recent identification of many inherited disorders involving aberrant ciliary function, termed “ciliopathies”, has changed this and primary cilia are now known as sensory organelles, acting both as chemo- or mechanosensors and transducers of signals that regulate key developmental signalling pathways. My lab focuses on the severe ciliopathy Meckel Gruber syndrome. We use a combination of patient-derived cell lines, post-genomic technologies, classical cell biology and genetics to give insight into the molecular cell biology of the disease. We are currently studying the roles that two proteins, TMEM67 and TMEM216, play in organisation of the actin and microtubule cytoskeletons during cell migration.

近期论文

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Barker AR, McIntosh KV, Dawe HR (2016). Centrosome positioning in non-dividing cells. Protoplasma, 253(4), 1007-1021. Abstract. Author URL. Martin-Urdiroz M, Deeks MJ, Horton CG, Dawe HR, Jourdain I (2016). The Exocyst Complex in Health and Disease. Frontiers in Cell and Developmental Biology, 4 Full text. Article has an altmetric score of 8 Barker AR, Renzaglia KS, Fry K, Dawe HR (2014). Bioinformatic analysis of ciliary transition zone proteins reveals insights into the evolution of ciliopathy networks. BMC Genomics, 15 Abstract. Author URL. Full text. Article has an altmetric score of 1 Locke JM, Da Silva Xavier G, Dawe HR, Rutter GA, Harries LW (2014). Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia, 57(1), 122-128. Abstract. Full text. Barker AR, Thomas R, Dawe HR (2014). Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development. Organogenesis, 10(1), 96-107. Abstract. Author URL. Article has an altmetric score of 1 Barker AR, McIntosh K, Dawe HR (2013). Meckel-Gruber syndrome proteins are required for actin cytoskeleton organisation and directional cell migration. MOLECULAR BIOLOGY OF THE CELL, 24 Author URL. Adams M, Simms RJ, Abdelhamed Z, Dawe HR, Szymanska K, Logan CV, Wheway G, Pitt E, Gull K, Knowles MA, et al (2012). A meckelin-filamin a interaction mediates ciliogenesis. Hum Mol Genet, 21(6), 1272-1286. Abstract. Author URL. Article has an altmetric score of 2 Adams M, Simms RJ, Abdelhamed Z, Dawe HR, Szymanska K, Logan CV, Wheway G, Pitt E, Gull K, Knowles MA, et al (2012). A meckelin-filamin a interaction mediates ciliogenesis. Human Molecular Genetics, 21(6), 1272-1286. Abstract. Article has an altmetric score of 2 Cheng YZ, Eley L, Hynes AM, Overman LM, Simms RJ, Barker A, Dawe HR, Lindsay S, Sayer JA (2012). Investigating embryonic expression patterns and evolution of AHI1 and CEP290 genes, implicated in Joubert syndrome. PLoS One, 7(9). Abstract. Author URL. Simms RJ, Hynes AM, Eley L, Inglis D, Chaudhry B, Dawe HR, Sayer JA (2012). Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development. Cellular and Molecular Life Sciences, 69(6), 993-1009. Abstract. Article has an altmetric score of 1 Simms RJ, Hynes AM, Eley L, Inglis D, Chaudhry B, Dawe HR, Sayer JA (2012). Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development. Cell Mol Life Sci, 69(6), 993-1009. Abstract. Author URL. Article has an altmetric score of 1 Thompson H, Shaw MK, Dawe HR, Shimeld SM (2012). The formation and positioning of cilia in Ciona intestinalis embryos in relation to the generation and evolution of chordate left-right asymmetry. Dev Biol, 364(2), 214-223. Abstract. Author URL. Vaughan S, Dawe HR (2011). Common themes in centriole and centrosome movements. Trends Cell Biol, 21(1), 57-66. Abstract. Author URL. Full text. Gluenz E, Höög JL, Smith AE, Dawe HR, Shaw MK, Gull K (2010). Beyond 9+0: noncanonical axoneme structures characterize sensory cilia from protists to humans. FASEB J, 24(9), 3117-3121. Abstract. Author URL. Article has an altmetric score of 6 Dawe HR, Adams M, Wheway G, Szymanska K, Logan CV, Noegel AA, Gull K, Johnson CA (2009). Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. J Cell Sci, 122(Pt 15), 2716-2726. Abstract. Author URL. Full text. Dawe HR, Gluenz E (2009). The tale of the trypanosome tail. Biologist, 56(4), 216-220. Dawe HR, Farr H, Gull K (2007). Centriole/basal body morphogenesis and migration during ciliogenesis in animal cells. J Cell Sci, 120(Pt 1), 7-15. Abstract. Author URL. Dawe HR, Smith UM, Cullinane AR, Gerrelli D, Cox P, Badano JL, Blair-Reid S, Sriram N, Katsanis N, Attie-Bitach T, et al (2007). The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation. Hum Mol Genet, 16(2), 173-186. Abstract. Author URL. Article has an altmetric score of 3 Dawe HR, Shaw MK, Farr H, Gull K (2007). The hydrocephalus inducing gene product, Hydin, positions axonemal central pair microtubules. BMC Biol, 5 Abstract. Author URL. Broadhead R, Dawe HR, Farr H, Griffiths S, Hart SR, Portman N, Shaw MK, Ginger ML, Gaskell SJ, McKean PG, et al (2006). Flagellar motility is required for the viability of the bloodstream trypanosome. Nature, 440(7081), 224-227. Abstract. Author URL.