Wang, Greg - The University of North Carolina at Chapel Hill - Lineberger Comprehensive Cancer Center

个人简介

Education 2007 - 2011 Postdoctoral fellow (mentor: C. David Allis), Laboratory of Chromatin Biology & Epigenetics, Rockefeller University, New York, NY, USA 2000 - 2006 Ph.D. in Biomedical Sciences (mentor: Mark P. Kamps; co-mentor: Christopher K. Glass),University of California San Diego (UCSD), La Jolla, CA, USA 1997 - 2000 M.S. in Pathogenic & Cancer Biology, Fudan University Medical Center, Shanghai, China 1993 - 1997 B.S. in Biochemistry, Fudan University School of Life Sciences, Shanghai, China C. Professional Experience 2022 - present Full Professor (tenured), Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 2018 - 2021 Associate Professor (tenured), Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics & Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 2012 - present Member, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 2012 - 2018 Assistant Professor (tenure track), Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC Dec 2011-April 2012Visiting Assistant Professor, Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC

研究领域

With an emphasis on chromatin biology and gene regulation, our research programs are broadly focused on mechanistic understandings of how chemical modifications of chromatin define distinctive patterns of mammalian genomes, control gene expression and regulate cell fates during development, and how their deregulations lead to human disease such as cancer, developmental disorder and aging. Routinely, we have taken a set of integrated biochemical and biophysical, genomics, oncology and medicinal chemistry approaches to tackle the broad and critical questions in this field. Often, inter-laboratory and interdisciplinary collaborations are instrumental in successful carryout of our projects. Our interest can roughly be summarized into the following research directions: (I) Histone modification ‘reader’ proteins in gene regulation and pathogenesis. (II) Phase separation underlying the gene regulation and 3D chromatin organization. (III) DNA methylation machineries in epigenetic regulation and pathogenesis. (IV) Chemical

近期论文

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Meng F*, Xu C*, Park KS, Kaniskan HÜ#, Wang GG#, Jin J#. Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos. J Med Chem. 2022 Jul 27. doi: 10.1021/acs.jmedchem.2c00807. Online ahead of print.PMID: 35895319 Gao L*, Guo Y*, Biswal M, Lu J, Yin J, Fang J, Chen X, Shao Z, Huang M, Wang Y, Wang GG#, Song J#. Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nat Commun. 2022 Jul 22;13(1):4249. doi: 10.1038/s41467-022-31933-w.PMID: 35869095 Herek TA, Bouska A, Lone WG, Sharma S, Amador C, Heavican-Foral TB, Li Y, Wei Q, Jochum D, Greiner TC, Smith LM, Pileri SA, Feldman A, Rosenwald A, Ott G, Lim ST, Ong CK, Song JY, Jaffe ES, Wang G, Staudt LM, Rimsza LM, Vose J, d'Amore F, Weisenburger DD, Chan WC, Iqbal J. DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T-cells in PTCL-NOS. Blood. 2022 May 31:blood.2021015019. doi: 10.1182/blood.2021015019. PMID: 35639959 Li D*, Yu X*, Kottur J, Gong W, Zhang Z, Storey AJ, Tsai YH, Uryu H, Shen Y, Byrum SD, Edmondson RD, Mackintosh SG, Cai L, Liu Z, Aggarwal AK, Tackett AJ, Liu J, Jin J#, Wang GG#. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022 May 7. doi: 10.1038/s41388-022-02340-8. PMID: 35525905 Quiroga IY*, Ahn JH*, Wang GG#, Phanstiel DH#. Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer. Curr Opin Genet Dev. 2022 Jun;74:101901. PMID: 35427897 Wang J*, Yu X*, Gong W, Liu X, Park KS, Ma A, Tsai YH, Shen Y, Onikubo T, Pi WC, Allison DF, Liu J, Chen WY, Cai L, Roeder RG, Jin J#, Wang GG#. EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. Nature Cell Biol. 2022 Feb 24. doi: 10.1038/s41556-022-00850-x. Ren Z*, Kim A*, Huang YH, Pi CH, Gong W, Yu X, Qi J, Jin J, Cai L, Roeder RG#, Chen WY#, Wang GG#. A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia. Proc Natl Acad Sci. 2022 Mar 1;119(9):e2122940119. PMID: 35217626. Phanstiel DH#, Wang GG#. Cell type-specific chromatin topology and gene regulation. Trends Genet. 2022 Feb 24:S0168-9525(22)00035-X. doi: 10.1016/j.tig.2022.02.008. PMID: 35221113 Spangler CJ*, Yadav SP*, Li D*, Geil CN, Smith CB, Wang GG#, Lee T#, and McGinty RK#. DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding. Cell Reports 2022 Feb 15;38(7):110369. PMID: 35172132. Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV#, Bell O#. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2021 Oct 26:S2451-9456(21)00437-2. PMID: 34715055 Yu X*, Li D*, Kottur J*, Shen Y, Kim HS, Park KS, Tsai YH, Gong W, Wang J, Suzuki K, Parker J, Herring L, Kaniskan HÜ, Cai L, Jain R, Liu J, Aggarwal AK, Wang GG#, Jin J#. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Science Translational Medicine. 2021 Sep 29;13(613):eabj1578. doi: 10.1126/scitranslmed.abj1578. Epub 2021 Sep 29. PMID: 34586829* Huang YT, Cheng AC, Tang HC, Huang GC, Cai L, Lin TH, Wu KJ, Tseng PH, Wang GG, Chen WY. USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer. Cell Death Dis. 2021 Sep 27;12(10):880. doi: 10.1038/s41419-021-04176-8. PMID: 34580281 Wei J, Meng F, Park KS, Yim H, Velez J, Kumar P, Wang L, Xie L, Chen H, Shen Y, Teichman E, Li D, Wang GG, Chen X, Kaniskan HÜ, Jin J. Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. J Am Chem Soc. 2021 Sep 14. doi: 10.1021/jacs.1c04841. PMID: 34520194 Xu C*, Meng F*, Park KS, Storey AJ, Gong W, Tsai YH, Gibson E, Byrum SD, Li D, Edmondson RD, Mackintosh SG, Vedadi M, Cai L, Tackett AJ, Kaniskan HÜ#, Jin J#, Wang GG#. A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Cell Chem Biol. 2021 Aug 30:S2451-9456(21)00393-7. PMID: 34469831. Kim A, Wang GG. R-loop and its functions at the regulatory interfaces between transcription and (epi)genome. Biochim Biophys Acta Gene Regul Mech. 2021 Aug 27:194750. PMID: 34461314 Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, Li J, Storey AJ, Tsai YH, Keeley DP, Mackintosh SG, Edmondson RD, Byrum SD, Cai L, Tackett AJ, Zheng D, Legant WR, Phanstiel DH#, Wang GG#. Phase separation drives aberrant chromatin looping and cancer development. Nature (2021) 595(7868):591-595. Epub 2021 Jun 23.* Zhao S, Allis CD, Wang GG. The language of chromatin modification in human cancers. Nat Rev Cancer. 2021 Jul;21(7):413-430.* PMID: 34002060. * With Editor’s cover illustration. Xu C, Tsai YH, Galbo PM, Gong W, Storey AJ, Xu Y, Byrum SD, Xu L, Whang YE, Parker JS, Mackintosh SG, Edmondson RD, Tackett AJ, Huang J, Zheng D, Earp HS, Wang GG#, Cai L#. Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. Nucleic Acid Res. (2021) May 21;49(9):4971- 4988. PMID: 33849067 Ren W*, Fan H*, Grimm SA, Guo Y, Kim JJ, Li L, Petell CJ, Tan XF, Zhang ZM, Coan JP, Yin J, Kim DI, Gao L, Cai L, Khudaverdyan N, Çetin B, Patel DJ, Wang Y, Cui Q, Strahl BD, Gozani O, Miller KM, O'Leary SE, Wade PA, Wang GG#, Song J#. DNMT1 reads heterochromatic H4K20me3 to reinforce DNA methylation of transposons. Nature communications. (2021) May 3; 12(1):2490. PMID: 33941775 Fan H*, Guo Y*, Tsai YH, Storey AJ, Kim A, Gong W, Mackintosh SG, Edmondson RG, Li H, Byrum SD, Tackett AJ, Cai L, Wang GG. A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. Nucleic Acid Res. (2021) May 7; 49(8):4441-4455. PMID: 33823544