Biedermann, Frank - Karlsruhe Institute of Technology - Institute of Nanotechnology (INT)

个人简介

12/2014 – 08/2016: Postdoc, Karlsruhe Institute for Technology (KIT), Institute for Nanotechnology (INT), with Prof. Dr. L. De Cola 12/2013 – 11/2014: Postdoc, Institut de Science et d'Ingénierie Supramoléculaires, Strasbourg, with Prof. Dr. L. De Cola 10/2012 – 11/2013: Postdoc, Jacobs University Bremen, with Prof. Dr. W. M. Nau 10/2008 – 10/2012: PhD in Chemistry, University of Cambridge, UK, with Dr. O. A. Scherman 10/2007 – 06/2008 Part III course in Chemistry, University of Cambridge, UK 10/2006 – 06/2007 Part-time studies Physics (1. and 2. semester), TU Kaiserslautern 10/2004 – 08/2007 B. Sc., Universität Leipzig

研究领域

The creation of artificial receptors remains an open challenge in supramolecular chemistry. In particular, the detection of small biomolecules in aqueous or complex biological media by supramolecular chemosensors proved difficult.[1] We have developed a remarkably facile and versatile biomimetic strategy for the design of high-affinity artificial receptors by exploiting a combination of specific analyte-host interactions and the powerful, non-classical hydrophobic effect as driving forces for binding.[2] Current developments include the monitoring of dynamic processes, e.g. of enzymatic reactions, and the extension of the sensors to applications in living cells.

近期论文

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Chemical Sensors Based on Cucurbit[n]uril Macrocycles S. Sinn, F. Biedermann, Isr. J. Chem. 2018, 58, 357-412. Platinum Complex Assemblies as Luminescent Probes and Tags for Drugs and Toxins in Water S. Sinn, F. Biedermann*, L. De Cola*, Chem. Eur. J. 2017, 23, 1965–1971. Experimental Binding Energies in Supramolecular Complexes F. Biedermann*, H.-J. Schneider*, Chem. Rev. 2016, 116, 5216-5300. Nanomolar Binding of Steroids to Cucurbit[n]urils: Selectivity and Applications A. I. Lazar; F. Biedermann*; K. R. Mustafina; K. I. Assaf; A. Hennig; W. M. Nau J. Am. Chem. Soc. 2016, 138, 13022-13029. Associative chemosensing by fluorescent macrocycle–dye complexes–a versatile enzyme assay platform beyond indicator displacement F. Biedermann*, D. Hathazi, W.M. Nau*, Chem. Commun. 2015, 51, 4977-4980. The Hydrophobic Effect Revisited—Studies with Supramolecular Complexes Imply High‐Energy Water as a Noncovalent Driving Force F. Biedermann*, W.M. Nau*, H.-J. Schneider*, Angew. Chem. Int. Ed. 2014, 53, 11158–11171. Noncovalent chirality sensing ensembles for the detection and reaction monitoring of amino acids, peptides, proteins, and aromatic Drugs F. Biedermann*, W.M. Nau*, Angew. Chem. Int. Ed. 2014, 53, 5694-5699. Cucurbit[8]uril and blue-box: high-energy water release overwhelms electrostatic interactions F. Biedermann*, M. Vendruscolo, O. A. Scherman, A. De Simone, W. M. Nau, J. Am. Chem. Soc., 2013, 135, 14879-14888. Release of high-energy water as an essential driving force for the high-affinity binding of cucurbit[n]urils F. Biedermann, V. D. Uzunova, O. A. Scherman, W. M. Nau, A. De Simone, J. Am. Chem. Soc., 2012, 134, 15318-15323. Strongly fluorescent, switchable perylene bis (diimide) host–guest complexes with cucurbit[8]uril in water F. Biedermann, E. Elmalem, I. Ghosh, W. M. Nau, O. A. Scherman, Angew. Chem. Int. Ed., 2012 51, 7739-7743.