蒋绪恺 - 山东大学 - 国家糖工程技术研究中心

个人简介

教育经历 2013.9-2018.6 ：山东大学，微生物技术国家重点实验室，理学博士 2009.9-2013.6 ：山东大学威海校区，海洋学院，理学学士工作经历 2021.4-至今：山东大学，国家糖工程技术研究中心副研究员 2018.9-2020.10：澳大利亚莫纳什大学，生物医药研发中心，博士后

研究领域

利用多尺度分子动力学模拟技术，整合化学生物学和分子生物学手段开展以下研究： 1. 探究细胞膜系统的结构功能机制，开展抗感染药物的智能化设计 2. 探究酶催化的分子机制，开展蛋白质功能的定制化设计

近期论文

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Jiang X, Patil A.N., Azad A.K.M., Wickremasinghe H., Yu H., Zhao J. Zhang X., Li M., Gong B., Wan L., Ma W., Tompson E.P., Yang K., Yuan B., Schreiber F., Wang L., Velkov T., Roberts D.K., Li J. A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii, Chem. Sci., 2021, 12: 12211-12220 (IF 9.825) Jiang X, Sun Y, Yang K, Yuan B, Velkov T, Wang L, Li J. Coarse-grained simulations uncover Gram-negative bacterial defense against polymyxins by the outer membrane. Comput. Struct. Biotechnol. J., 2021, 19: 3885-3891. (IF 7.272) Zhu Y#, Lu J#, Han ML#, Jiang X#, Azad MAK, Patil NA, Lin YW, Zhao J, Hu Y, Yu HH, Chen K, Boyce JD, Dunstan RA, Lithgow T, Barlow CK, Li W, Schneider-Futschik EK, Wang J, Gong B, Sommer B, Creek DJ, Fu J, Wang L, Schreiber F, Velkov T, Li J. Polymyxins bind to the cell surface of unculturable Acinetobacter baumannii and cause unique dependent resistance. Adv. Sci., 2020, 7:2000704. (IF 16.803, Cover Story) Jiang X, Yang K, Yuan B, Gong B, Wan L, Patil NA, Swarbrick JD, Roberts KD, Schreiber F, Wang L, Velkov T, Li J. Simulations of octapeptin-outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency, J. Biol. Chem. 2020, 295: 15902-15912 (IF 5.153). Jiang X, Yang K, Yuan B, Han M, Zhu Y, Roberts KD, Patil NA, Li J, Gong B, Hancock REW, Velkov T, Schreiber F, Wang L, Li J. Molecular dynamics simulations informed by membrane lipidomics reveal the structure–interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii, J. Antimicrob. Chemother. 2020, 75: 3534-3543 (IF 5.794). Jiang X, Zhang S, Azad MAK, Roberts KD, Wan L, Gong B, Yang K, Yuan B, Uddin H, Li J, Thompson PE, Velkov T, Fu J, Wang L, Li J. Structure–interaction relationship of polymyxins with the membrane of human kidney proximal tubular cells, ACS Infect. Dis. 2020, 6: 2110-2119 (IF 5.084). Jiang X, Yang K, Han ML, Yuan B, Li J, Gong B, Velkov T, Schreiber F, Wang L, Li J. Outer membranes of polymyxin-resistant Acinetobacter baumannii with phosphoethanolamine-modified lipid A and lipopolysaccharide loss display different atomic-scale interactions with polymyxins, ACS Infect. Dis. 2020, 6: 2698-2708 (IF 5.084, Cover Story). Jiang X, Li W, Chen G, Wang L. Dynamic perturbation of the active site determines reversible thermal inactivation in glycoside hydrolase family 12. J. Chem. Inf. Model., 2017, 2: 288-297. (IF 4.954)