Chahwan, Richard - University of Exeter - Disciplines of Biosciences

个人简介

2016-present: Senior Lecturer in Molecular Immunobiology, Biosciences, University of Exeter. 2013-2016: Lecturer in Molecular Immunobiology, Biosciences, University of Exeter. 2008-2013: Research Associate, Rockefeller University & Albert Einstein College of Medicine 2007: PhD Molecular Cell Biology, Gurdon Institute, University of Cambridge

研究领域

Research interests Humans and other mammals are constantly required to safeguard their genomic integrity from environmental toxins and defend themselves from lethal foreign agents. An adequate DNA damage response (DDR) achieves the former; while the latter is ensured by the acquired immune system, especially the antibody response in B cells. Interestingly, the DDR also contributes to the generation of the huge immune diversity needed to protect us against foreign antigens. My lab is interested in understanding the fundamental principles that maintain chromatin integrity and generate immune diversity. This includes studying the complimentary role of the DDR in DNA editing through cytosine deamination. We are also interested in studying the genetic and epigenetic contribution of the DDR to normal cell function and the development of various human diseases such as immunodeficiencies, autoimmunity, tumorigenesis, and aging.

近期论文

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Harmer NJ, Chahwan R (2016). Isotype switching: Mouse IgG3 constant region drives increased affinity for polysaccharide antigens. Virulence, 7(6), 623-626. Author URL. Full text. Article has an altmetric score of 1 Wei L, Chahwan R, Wang S, Wang X, Pham PT, Goodman MF, Bergman A, Scharff MD, MacCarthy T (2015). Overlapping hotspots in CDRs are critical sites for V region diversification. Proc Natl Acad Sci U S A, 112(7), E728-E737. Abstract. Author URL. Full text. Van Oers JMM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan X, Schaetzlein S, Jin B, Wang Y, Bergman A, et al (2014). The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair. Oncogene, 33(30), 3939-3946. Abstract. Full text. Chahwan R, Gravel S, Matsusaka T, Jackson SP (2013). Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins. Cell Cycle, 12(6), 1000-1008. Abstract. Author URL. Full text. Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, et al (2013). Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A, 110(27), E2470-E2479. Abstract. Author URL. Chahwan R, Gravel S, Matsusaka T, Jackson SP (2013). RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures. Cell Cycle, 12(8), 1161-1162. Author URL. Full text. Chahwan R, Edelmann W, Scharff MD, Roa S (2012). AIDing antibody diversity by error-prone mismatch repair. Semin Immunol, 24(4), 293-300. Abstract. Author URL. Chahwan C, Chahwan R (2012). Aicardi-Goutieres syndrome: from patients to genes and beyond. Clin Genet, 81(5), 413-420. Abstract. Author URL. Article has an altmetric score of 3 Chahwan R, van Oers JM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S (2012). The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination. J Exp Med, 209(4), 671-678. Abstract. Author URL. Full text. Article has an altmetric score of 1 Chahwan R, Edelmann W, Scharff MD, Roa S (2011). Mismatch-mediated error prone repair at the immunoglobulin genes. Biomed Pharmacother, 65(8), 529-536. Abstract. Author URL. Chahwan R, Wontakal SN, Roa S (2011). The multidimensional nature of epigenetic information and its role in disease. Discov Med, 11(58), 233-243. Abstract. Author URL. Chahwan R, Wontakal SN, Roa S (2010). Crosstalk between genetic and epigenetic information through cytosine deamination. Trends Genet, 26(10), 443-448. Abstract. Author URL. Article has an altmetric score of 3 Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A, et al (2010). The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proc Natl Acad Sci U S A, 107(2), 809-814. Abstract. Author URL. Article has an altmetric score of 1 Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, et al (2007). Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science, 318(5856), 1637-1640. Abstract. Author URL. Article has an altmetric score of 9 McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, et al (2004). Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science, 304(5678), 1822-1826. Abstract. Author URL. Abraham J, Lemmers B, Hande MP, Moynahan ME, Chahwan C, Ciccia A, Essers J, Hanada K, Chahwan R, Khaw AK, et al (2003). Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J, 22(22), 6137-6147. Abstract. Author URL. Article has an altmetric score of 3 Matar GM, Chahwan R, Fuleihan N, Uwaydah M, El-Hajj M, Hadi U (2002). DNA-based subtypes and antimicrobial susceptibility profiles of Haemophilus influenzae and Haemophilus parainfluenzae isolated from different tonsillar sites of children undergoing tonsillectomy and/or adenoidectomy. J Med Liban, 50(4), 157-162. Abstract. Author URL. Matar GM, Chahwan R, Fuleihan N, Uwaydah M, Hadi U (2001). PCR-based detection, restriction endonuclease analysis, and transcription of tonB in Haemophilus influenzae and Haemophilus parainfluenzae isolates obtained from children undergoing tonsillectomy and adenoidectomy. Clin Diagn Lab Immunol, 8(2), 221-224. Abstract. Author URL. Wang S, Chahwan R, Wei L, Scharff MD (In Press). Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation. In (Ed) Encyclopedia of Immunobiology, Elsevier. Abstract. Martin A, Chahwan R, Parsa JY, Scharff MD (2014). Somatic Hypermutation: the Molecular Mechanisms Underlying the Production of Effective High-Affinity Antibodies. In Honjo T, Reth M, Radbruch A, Alt F (Eds.) Molecular Biology of B Cells, Academic Press, 363-388. Abstract.