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个人简介

2014 Senior Fellow of The Higher Education Academy 2001 Certificate in Learning and Teaching, Faculty of Education, University of Newcastle 1995 PhD Microbial Biochemistry, King's College, University of London 1991 BSc (Hons) Biotechnology, King's College, University of London Career 2012 – present Associate Professor in Microbial Biochemistry, Biosciences, CLES, University of Exeter 2006-2012 Senior Lecturer in Biochemistry, School of Biosciences, University of Exeter 2000-2006 Lecturer in Biochemistry, Institute for Cell and Molecular Biosciences, University of Newcastle 1995-2000 Senior Research Associate, Centre for Metalloprotein Spectroscopy and Biology (CMSB). University of East Anglia, Norwich

研究领域

My research interests lie in the study of the microbiology and biochemistry of important mineral cycles, with specific focus on the microbial interaction with selenium and nitrogen. The main objective of my work is to characterize the biochemical reactions of these cycles in whole cells and cell fractions. We study gene expression and protein synthesis in response to environmental change; investigate electron-transfer reactions between proteins involved in respiratory pathways; and purify and characterize proteins and enzymes to reveal their structure and function. We study a range of organisms including human pathogens, soil bacteria, archaea and algae, and use a combination of whole cell physiology, molecular genetics, enzymology, spectroscopy, imaging and structural biology. This work has implications for understanding how pathogens can survive and colonize within a host during infection, through to the synthetic exploitation of bacterial biomineralization for the environmentally friendly and cost efficient fabrication of novel nanomaterials.

近期论文

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Lampis S, Zonaro E, Bertolini C, Cecconi D, Monti F, Micaroni M, Turner RJ, Butler CS, Vallini G (2016). Selenite biotransformation and detoxification by Stenotrophomonas maltophilia SeITE02: Novel clues on the route to bacterial biogenesis of selenium nanoparticles. J Hazard Mater Abstract. Author URL. Article has an altmetric score of 1 Hemsley CM, Luo JX, Andreae CA, Butler CS, Soyer OS, Titball RW (2014). Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration. Antimicrob Agents Chemother, 58(10), 5775-5783. Abstract. Author URL. Lampis S, Zonaro E, Bertolini C, Bernardi P, Butler CS, Vallini G (2014). Delayed formation of zero-valent selenium nanoparticles by Bacillus mycoides SeiTE01 as a consequence of selenite reduction under aerobic conditions. Microbial Cell Factories, 13(1), 1-14. Abstract. Bertolini C, van Aerle R, Lampis S, Moore KA, Paszkiewicz K, Butler CS, Vallini G, van der Giezen M (2014). Draft Genome Sequence of Stenotrophomonas maltophilia SeITE02, a Gammaproteobacterium Isolated from Selenite-Contaminated Mining Soil. Genome Announc, 2(3). Abstract. Author URL. Article has an altmetric score of 4 Andreae CA, Titball RW, Butler CS (2014). Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis. Res Microbiol, 165(1), 41-49. Abstract. Author URL. Full text. Article has an altmetric score of 1 Wagley S, Hemsley C, Thomas R, Moule MG, Vanaporn M, Andreae C, Robinson M, Goldman S, Wren BW, Butler CS, et al (2014). The twin arginine translocation system is essential for aerobic growth and full virulence of Burkholderia thailandensis. J Bacteriol, 196(2), 407-416. Abstract. Author URL. Article has an altmetric score of 1 Butler CS, Debieux CM, Dridge EJ, Splatt P, Wright M (2012). Biomineralization of selenium by the selenate-respiring bacterium Thauera selenatis. Biochemical Society Transactions, 40(6), 1239-1243. Abstract. Butler CS (2012). Metals, non-metals and minerals: the complexity of bacterial selenate respiration. Biochemist, 34(5), 23-27. Abstract. Debieux CM, Dridge EJ, Mueller CM, Splatt P, Paszkiewicz K, Knight I, Florance H, Love J, Titball RW, Lewis RJ, et al (2011). A bacterial process for selenium nanosphere assembly. Proceedings of the National Academy of Sciences of the United States of America, 108(33), 13480-13485. Abstract. Full text. Gates AJ, Butler CS, Richardson DJ, Butt JN (2011). Electrocatalytic reduction of nitrate and selenate by NapAB. Biochemical Society Transactions, 39(1), 236-242. Abstract. Lowe EC, Bydder S, Hartshorne RS, Tape HL, Dridge EJ, Debieux CM, Paszkiewicz K, Singleton I, Lewis RJ, Santini JM, et al (2010). Quinol-cytochrome c oxidoreductase and cytochrome c4 mediate electron transfer during selenate respiration in Thauera selenatis. J Biol Chem, 285(24), 18433-18442. Abstract. Author URL. Full text. Dridge EJ, Butler CS (2010). Thermostable properties of the periplasmic selenate reductase from Thauera selenatis. Biochimie, 92(10), 1268-1273. Abstract. Hall SJ, Hitchcock A, Butler CS, Kelly DJ (2009). A Multicopper Oxidase (Cj1516) and a CopA Homologue (Cj1161) Are Major Components of the Copper Homeostasis System of Campylobacter jejuni (vol 190, pg 8075, 2009). JOURNAL OF BACTERIOLOGY, 191(3), 1122-1122. Author URL. Hall SJ, Hitchcock A, Butler CS, Kelly DJ (2008). A multicopper oxidase (Cj1516) and a CopA homologue (Cj1161) are major components of the copper homeostasis system of Campylobacter jejuni. Journal of Bacteriology, 190(24), 8075-8085. Abstract. Full text. Leaver JT, Richardson DJ, Butler CS (2008). Enterobacter cloacae SLD1a-1 gains a selective advantage from selenate reduction when growing in nitrate-depleted anaerobic environments. Journal of Industrial Microbiology and Biotechnology, 35(8), 867-873. Abstract. Article has an altmetric score of 1 Campbell SC, Aldibbiat A, Marriott CE, Landy C, Ali T, Ferris WF, Butler CS, Shaw JA, Macfarlane WM (2008). Selenium stimulates pancreatic beta-cell gene expression and enhances islet function. FEBS Letters, 582(15), 2333-2337. Abstract. Huston WM, Harhangi HR, Leech AP, Butler CS, Jetten MSM, Op den Camp HJM, Moir JWB (2007). Expression and characterisation of a major c-type cytochrome encoded by gene kustc0563 from Kuenenia stuttgartiensis as a recombinant protein in Escherichia coli. Protein Expression and Purification, 51(1), 28-33. Abstract. Dridge EJ, Watts CA, Jepson BJN, Line K, Santini JM, Richardson DJ, Butler CS (2007). Investigation of the redox centres of periplasmic selenate reductase from Thauera selenatis by EPR spectroscopy. Biochemical Journal, 408(1), 19-28. Abstract. Martinez-Espinosa RM, Dridge EJ, Bonete MJ, Butt JN, Butler CS, Sargent F, Richardson DJ (2007). Look on the positive side! the orientation, identification and bioenergetics of 'Archaeal' membrane-bound nitrate reductases. FEMS Microbiology Letters, 276(2), 129-139. Abstract. Campbell SC, Richardson H, Ferris WF, Butler CS, Macfarlane WM (2007). Nitric oxide stimulates insulin gene transcription in pancreatic β-cells. Biochemical and Biophysical Research Communications, 353(4), 1011-1016. Abstract.

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