Brown, Alan - University of Exeter - Disciplines of Biosciences

个人简介

2010 Postgraduate Certificate in Academic Practice, University of Exeter 2001 PhD, University of Edinburgh 1997 BSc (Hons) Medical Microbiology, University of Edinburgh Career 2013-Present Senior Lecturer in Molecular Microbiology, School of Biosciences, University of Exeter 2008-2013 Lecturer in Molecular Microbiology, School of Biosciences, University of Exeter 2005-2008 Postdoctoral Fellow & Coordinator of the UK Cystic Fibrosis Microbiology Consortium, Centre for Infectious Diseases, University of Edinburgh 2003-2005 Postdoctoral Scientist, The Roslin Institute 2000-2003 Postdoctoral Research Associate, Dept. of Veterinary Pathology, University of Edinburgh

研究领域

My research primarily focuses on Pseudomonas aeruginosa and species of the Burkholderia genus, specifically Burkholderia pseudomallei and members of the Burkholderia cepacia complex (Bcc). P. aeruginosa and the Bcc are both formidable pathogens of the cystic fibrosis (CF) lung, whilst P. aeruginosa is also a significant cause of healthcare-associated infection. In contrast, B. pseudomallei is the causative agent of melioidosis, a disease which is endemic in parts of southeast Asia and northern Australia. I am interested in the fundamental mechanisms that underlie the virulence of these organisms, how genome and transcriptome plasticity facilitates their adaptation to diverse niches, and how knowledge of these processes can guide the development of novel therapeutic strategies.

近期论文

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Custódio R, McLean CJ, Scott AE, Lowther J, Kennedy A, Clarke DJ, Campopiano DJ, Sarkar-Tyson M, Brown AR (2016). Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei. Mol Microbiol Abstract. Author URL. Full text. Article has an altmetric score of 2 Denman CC, Robinson MT, Sass AM, Mahenthiralingam E, Brown AR (2014). Growth on mannitol-rich media elicits a genomewide transcriptional response in Burkholderia multivorans that impacts on multiple virulence traits in an exopolysaccharide-independent manner. Microbiology (United Kingdom), 160(PART 1), 187-197. Abstract. Article has an altmetric score of 1 Denman CC, Brown AR (2013). Mannitol promotes adherence of an outbreak strain of Burkholderia multivorans via an exopolysaccharide-independent mechanism that is associated with upregulation of newly identified fimbrial and afimbrial adhesins. Microbiology (United Kingdom), 159(4), 771-781. Abstract. Clarke DJ, Ortega XP, Mackay CL, Valvano MA, Govan JRW, Campopiano DJ, Langridge-Smith P, Brown AR (2010). Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity. Biochemistry, 49(6), 1319-1330. Abstract. Full text. Clarke DJ, Mackay CL, Campopiano DJ, Langridge-Smith P, Brown AR (2009). Interrogating the molecular details of the peroxiredoxin activity of the Escherichia coli bacterioferritin comigratory protein using high-resolution mass spectrometry. Biochemistry, 48(18), 3904-3914. Abstract. Author URL. Full text. Bartholdson SJ, Brown AR, Mewburn BR, Clarke DJ, Fry SC, Campopiano DJ, Govan JR (2008). Plant host and sugar alcohol induced exopolysaccharide biosynthesis in the Burkholderia cepacia complex. Microbiology, 154(Pt 8), 2513-2521. Abstract. Full text. Ortega XP, Cardona ST, Brown AR, Loutet SA, Flannagan RS, Campopiano DJ, Govan JR, Valvano MA (2007). A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability. J Bacteriol., 189(9), 3639-3644. Abstract. Brown AR, Govan JR (2007). Assessment of fluorescent in situ hybridization and PCR-based methods for rapid identification of Burkholderia cepacia complex organisms directly from sputum samples. J Clin Microbiol, 45(6), 1920-1926. Abstract. Author URL. Brown AR, Blanco AR, Miele G, Hawkins SA, Hopkins J, Fazakerley JK, Manson J, Clinton M (2007). Differential expression of erythroid genes in prion disease. Biochem Biophys Res Commun, 364(2), 366-371. Abstract. Author URL. Govan JR, Brown AR, Jones AM (2007). Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection. Future Microbiol, 2(2), 153-164. Abstract. Author URL. Brown AR, Rebus S, McKimmie CS, Robertson K, Williams A, Fazakerley JK (2005). Gene expression profiling of the preclinical scrapie-infected hippocampus. Biochem Biophys Res Commun, 334(1), 86-95. Abstract. Author URL. Brown AR, Webb J, Rebus S, Williams A, Fazakerley JK (2004). Identification of up-regulated genes by array analysis in scrapie-infected mouse brains. Neuropathol Appl Neurobiol, 30(5), 555-567. Abstract. Author URL. Brown AR, Webb J, Rebus S, Walker R, Williams A, Fazakerley JK (2003). Inducible cytokine gene expression in the brain in the ME7/CV mouse model of scrapie is highly restricted, is at a strikingly low level relative to the degree of gliosis and occurs only late in disease. J Gen Virol, 84(Pt 9), 2605-2611. Abstract. Author URL. Brown AR, Townsley AC, Amyes SG (2001). Diversity of Tn1546 elements in clinical isolates of glycopeptide-resistant enterococci from Scottish hospitals. Antimicrob Agents Chemother, 45(4), 1309-1311. Abstract. Author URL. Nelson RR, McGregor KF, Brown AR, Amyes SG, Young H (2000). Isolation and characterization of glycopeptide-resistant enterococci from hospitalized patients over a 30-month period. J Clin.Microbiol., 38(6), 2112-2116. Abstract. Brown AR, Amyes SG, Paton R, Plant WD, Stevenson GM, Winney RJ, Miles RS (1998). Epidemiology and control of vancomycin-resistant enterococci (VRE) in a renal unit. J Hosp.Infect., 40(2), 115-124. Abstract.