Bayer-Wilfert, Lena - University of Exeter - Disciplines of Biosciences

个人简介

I am an evolutionary geneticist with particular interest in host-parasite interactions. To study the ecological and evolutionary risk factors that drive multi-host pathogens and emerging diseases, I use rapidly evolving viral pathogens that infect pollinating insects as an ecologically relevant model system. With a Royal Society Dorothy Hodgkin fellowship, I have recently shown that the globally distributed strain of DWV is a re-emerging man-made epidemic in honeybees and we have reviewed the biological and anthropogenic risk factors driving disease emergence in pollinators. We are currently following up this work by studying the effect of Varroa on disease prevalence and abundance as well as on viral diversity in wild pollinators. Visit our lab website to find out more. During my PhD with Paul Schmid-Hempel at ETH Zurich, I studied the quantitative genetics of disease resistance and immunity in bumblebees. As a post-doc with Frank Jiggins, first at the University of Edinburgh and then at the University of Cambridge, I studied the coevolutionary dynamics of Drosophila melanogaster and the sigma virus, a vertically transmitted parasite.

研究领域

Host-parasite coevolution is at the center of my research interests - find out more about our research on our lab webiste! In particular, I am interested in the ecology and evolution of emerging diseases. Using rapidly evolving RNA viruses that infect the community of pollinating insects, I study the ecological and genetic risk factors that may lead to disease emergence in this system. My work focuses on viral sequence evolution and the dynamics of pathogen adaptation.

近期论文

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Mordecai G, Bayer-Wilfert L, Martin S, Jones I, Schroeder D (In Press). Diversity in a honey bee pathogen: first report of a third master variant of the Deformed Wing Virus quasispecies. The ISME Journal: multidisciplinary journal of microbial ecology Abstract. Full text. Wilfert L, Long G, Leggett HC, Schmid-Hempel P, Butlin R, Martin SJM, Boots M (2016). Deformed wing virus is a recent global epidemic in honeybees driven by Varroa mites. Science, 351(6273), 594-597. Full text. Article has an altmetric score of 640 Manley R, Boots M, Wilfert L (2015). Emerging viral disease risk to pollinating insects: ecological, evolutionary and anthropogenic factors. J Appl Ecol, 52, 331-340. Author URL. Full text. Article has an altmetric score of 91 Wilfert L, Jiggins FM (2014). Flies on the move: an inherited virus mirrors Drosophila melanogaster's elusive ecology and demography. Mol Ecol, 23(8), 2093-2104. Abstract. Author URL. Full text. Article has an altmetric score of 5 Wilfert L, Jiggins FM (2013). The dynamics of reciprocal selective sweeps of host resistance and a parasite counter-adaptation in drosophila. Evolution, 67(3), 761-773. Abstract. Article has an altmetric score of 10 Stolle E, Wilfert L, Schmid-Hempel R, Schmid-Hempel P, Kube M, Reinhardt R, Moritz RF (2011). A second generation genetic map of the bumblebee Bombus terrestris (Linnaeus, 1758) reveals slow genome and chromosome evolution in the Apidae. BMC Genomics, 12 Abstract. Author URL. Longdon B, Wilfert L, Osei-Poku J, Cagney H, Obbard DJ, Jiggins FM (2011). Host-switching by a vertically transmitted rhabdovirus in Drosophila. Biol Lett, 7(5), 747-750. Abstract. Author URL. Article has an altmetric score of 3 Longdon B, Wilfert L, Obbard DJ, Jiggins FM (2011). Rhabdoviruses in two species of Drosophila: vertical transmission and a recent sweep. Genetics, 188(1), 141-150. Abstract. Author URL. Article has an altmetric score of 4 Wilfert L, Longdon B, Ferreira AG, Bayer F, Jiggins FM (2011). Trypanosomatids are common and diverse parasites of Drosophila. Parasitology, 138(7), 858-865. Abstract. Author URL. Wilfert L, Jiggins FM (2010). Disease association mapping in Drosophila can be replicated in the wild. Biol Lett, 6(5), 666-668. Abstract. Author URL. Wilfert L, Jiggins FM (2010). Host-parasite coevolution: genetic variation in a virus population and the interaction with a host gene. J Evol Biol, 23(7), 1447-1455. Abstract. Author URL. Wilfert L, Torres MM, Reber-Funk C, Schmid-Hempel R, Tomkins J, Gadau J, Schmid-Hempel P (2009). Construction and characterization of a BAC-library for a key pollinator, the bumblebee Bombus terrestris L. Insectes Sociaux, 56(1), 44-48. Abstract. Carpenter JA, Keegan LP, Wilfert L, O'Connell MA, Jiggins FM (2009). Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae). BMC Genet, 10 Abstract. Author URL. Wilfert L, Schmid-Hempel P (2008). The genetic architecture of susceptibility to parasites. BMC Evol Biol, 8 Abstract. Author URL. Wilfert L, Gadau J, Baer B, Schmid-Hempel P (2007). Natural variation in the genetic architecture of a host-parasite interaction in the bumblebee Bombus terrestris. Mol Ecol, 16(6), 1327-1339. Abstract. Author URL. Wilfert L, Gadau J, Schmid-Hempel P (2007). The genetic architecture of immune defense and reproduction in male Bombus terrestris bumblebees. Evolution, 61(4), 804-815. Abstract. Author URL. Wilfert L, Gadau J, Schmid-Hempel P (2007). Variation in genomic recombination rates among animal taxa and the case of social insects. Heredity (Edinb), 98(4), 189-197. Abstract. Author URL. Article has an altmetric score of 6 Wilfert L, Gadau J, Schmid-Hempel P (2006). A core linkage map of the bumblebee Bombus terrestris. Genome, 49(10), 1215-1226. Abstract. Author URL. Wilfert L, Kaib M, Durka W, Brandl R (2006). Differentiation between populations of a termite in eastern Africa: Implications for biogeography. Journal of Biogeography, 33(11), 1993-2000. Abstract. Kaib M, Jmhasly P, Wilfert L, Durka W, Franke S, Francke W, Leuthold RH, Brandl R (2004). Cuticular hydrocarbons and aggression in the termite Macrotermes subhyalinus. J Chem Ecol, 30(2), 365-385. Abstract. Author URL.