Bates, Steven - University of Exeter - Disciplines of Biosciences

个人简介

2012-present Senior Lecturer in Molecular Microbiology, University of Exeter 2006-2012 Lecturer in Molecular Microbiology, University of Exeter 2003-2006 Postdoctoral Research Fellow, University of Aberdeen 2001-2003 Senior Scientist, Oxford GlycoSciences UK Ltd 2000-2001 Postdoctoral Research Associate, University of Sheffield 1998-2000 Postdoctoral Research Fellow, University of Aberdeen 1997-1998 Postdoctoral Research Assistant, University of Leicester

研究领域

My research interests are in the molecular and cellular biology of the human fungal pathogens Candida albicans and Aspergillus fumigatus. The main research programs focus on C. albicans as a model organism to identify and study fungal virulence factors. A striking feature of C. albicans is its ability to grow in a variety of morphological forms, ranging from budding yeast to true hyphae with parallel-sided walls. The ability to switch between morphological forms is linked to virulence. My work concentrates on understanding the mechanisms that establish and regulate polarised growth in the different morphological forms, and the interplay of such processes with the cell cycle. My other main research interest is in identifying the cell surface and secreted epitopes that contribute to the host-fungal interaction and virulence. This currently includes the dissection of a family of Candida- specific cell wall proteins implicated in pathogenicity, and investigating the role of carbohydrate epitopes in C. albicans and A. fumigatus.

近期论文

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Milne SW, Cheetham J, Lloyd D, Shaw S, Moore K, Paszkiewicz KH, Aves SJ, Bates S (2014). Role of Candida albicans Tem1 in mitotic exit and cytokinesis. Fungal Genet Biol, 69, 84-95. Abstract. Author URL. Full text. Article has an altmetric score of 2 Parham H, Bates S, Xia Y, Zhu Y (2013). A highly efficient and versatile carbon nanotube/ceramic composite filter. Carbon, 54, 215-223. Abstract. Full text. Islahudin F, Khozoie C, Bates S, Ting KN, Pleass RJ, Avery SV (2013). Cell wall perturbation sensitizes fungi to the antimalarial drug chloroquine. Antimicrob Agents Chemother, 57(8), 3889-3896. Abstract. Author URL. Full text. Article has an altmetric score of 1 Bates S, Hall RA, Cheetham J, Netea MG, MacCallum DM, Brown AJ, Odds FC, Gow NA (2013). Role of the Candida albicans MNN1 gene family in cell wall structure and virulence. BMC Res Notes, 6 Abstract. Author URL. Full text. Hall RA, Bates S, Lenardon MD, Maccallum DM, Wagener J, Lowman DW, Kruppa MD, Williams DL, Odds FC, Brown AJ, et al (2013). The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans. PLoS Pathog, 9(4). Abstract. Author URL. Full text. Article has an altmetric score of 4 Hall RA, Bates S, Wagener J, Odds FC, Alvarez FJ, Brown AJP, Gow NAR (2012). Mannosylation of Candida albicans and its importance for immune recognition. MYCOSES, 55, 67-67. Author URL. Milne SW, Cheetham J, Lloyd D, Aves S, Bates S (2011). Cassettes for PCR-mediated gene tagging in Candida albicans utilizing nourseothricin resistance. Yeast, 28(12), 833-841. Abstract. Author URL. Full text. Mora-Montes HM, Bates S, Netea MG, Castillo L, Brand A, Buurman ET, Díaz-Jiménez DF, Jan Kullberg B, Brown AJ, Odds FC, et al (2010). A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions. J Biol Chem, 285(16), 12087-12095. Abstract. Author URL. Mora-Montes HM, Netea MG, Sheth CC, Brown GD, Bates S, Kullberg BJ, Brown AJP, Odds FC, Gow NAR (2009). Candida albicans cell wall glycobiology: biosynthesis of N-linked mannans and interaction with the host innate immune system. MYCOSES, 52, 24-24. Author URL. Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, et al (2009). Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature, 459(7247), 657-662. Abstract. Author URL. Article has an altmetric score of 17 Chaves GM, Bates S, Maccallum DM, Odds FC (2007). Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model. Genet Mol Res, 6(4), 1051-1063. Abstract. Author URL. Bates S, de la Rosa JM, MacCallum DM, Brown AJ, Gow NA, Odds FC (2007). Candida albicans Iff11, a secreted protein required for cell wall structure and virulence. Infect Immun, 75(6), 2922-2928. Abstract. Author URL. Mora-Montes HM, Bates S, Netea MG, Díaz-Jiménez DF, López-Romero E, Zinker S, Ponce-Noyola P, Kullberg BJ, Brown AJP, Odds FC, et al (2007). Endoplasmic reticulum α-glycosidases of Candida albicans are required for N glycosylation, cell wall integrity, and normal host-fungus interaction. Eukaryotic Cell, 6(12), 2184-2193. Abstract. Gow NA, Netea MG, Munro CA, Ferwerda G, Bates S, Mora-Montes HM, Walker L, Jansen T, Jacobs L, Tsoni V, et al (2007). Immune recognition of Candida albicans beta-glucan by dectin-1. J Infect Dis, 196(10), 1565-1571. Abstract. Author URL. Netea MG, Gow NA, Munro CA, Bates S, Collins C, Ferwerda G, Hobson RP, Bertram G, Hughes HB, Jansen T, et al (2006). Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J Clin Invest, 116(6), 1642-1650. Abstract. Author URL. Article has an altmetric score of 1 Bates S, Hughes HB, Munro CA, Thomas WP, MacCallum DM, Bertram G, Atrih A, Ferguson MA, Brown AJ, Odds FC, et al (2006). Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans. J Biol Chem, 281(1), 90-98. Abstract. Author URL. Braun BR, Hoog MV, d'Enfert C, Martchenko M, Dungan J, Kuo A, Inglis DO, Uhl MA, Hogues H, Berriman M, et al (2005). A human-curated annotation of the Candida albicans genome. PLOS GENETICS, 1(1), 36-57. Author URL. Article has an altmetric score of 6 Bates S, MacCallum DM, Bertram G, Munro CA, Hughes HB, Buurman ET, Brown AJ, Odds FC, Gow NA (2005). Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulence. J Biol Chem, 280(24), 23408-23415. Abstract. Author URL. Munro CA, Bates S, Buurman ET, Hughes HB, Maccallum DM, Bertram G, Atrih A, Ferguson MA, Bain JM, Brand A, et al (2005). Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. J Biol Chem, 280(2), 1051-1060. Abstract. Author URL. Chapa y Lazo B, Bates S, Sudbery P (2005). The G1 cyclin Cln3 regulates morphogenesis in Candida albicans. Eukaryot Cell, 4(1), 90-94. Abstract. Author URL.