个人简介
王曦,男。王曦博士于2005 年在哈尔滨工业大学获工学学士学位,2011 年在清华大学获工学博士学位(模式识别、生物信息学方向)。2011 至2020 年先后在澳大利亚纽卡斯尔大学生医与药学院、德国马克斯德尔布吕克分子医学中心、德国国家癌症研究中心从事生物信息学为主的科研工作。迄今以第一、共一、通讯作者发表在Cell Stem Cell、Immunity、Nature Communications、Nature Methods、Nucleic Acids Research、Molecular Systems Biology 等国际著名期刊上发表SCI论文 17 篇,共发表 SCI 论文 31 篇,总被 SCI 论文他引3000 余次。
课题组研究方向为:配子发生和早期胚胎发育的功能基因组学。旨在利用高通量测序、单细胞组学、系统生物学等方法,在全基因组尺度上研究配子发生、早期胚胎发育中的基因表达调控和细胞命运决定机制等。课题组同时开展生物信息学、系统生物学、生物医学大数据的算法开发等工作。
近期论文
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1. Xi Wang*, Jingyi Hou*, Claudia Quedenau, Wei Chen#. Pervasive isoform-specific translational regulation via alternative transcription start sites in mammals. Molecular Systems Biology,2016, 12(7): 875(封面文章)
2. Xi Wang*#, Xintian You*, Julian D. Langer, Jingyi Hou, Fiona Rupprecht, Irena Vlatkovic, Claudia Quedenau, Georgi Tushev, Irina Epstein, Bernhard Schaefke, Wei Sun, Liang Fang, Guipeng Li, Yuhui Hu, Erin M Schuman, Wei Chen#. Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus. Nature Communications,2019, 10: 5009
3. Xi Wang*#, Murray J. Cairns, Jian Yan#. Super-enhancers in transcriptional regulation and genome organization. Nucleic Acids Research, 2019, 47(22): 11481–11496.
4. Jing Ni*, Xi Wang*, Ana Stojanovic*, Qin Zhang, Marian Wincher, Lea Bühler, Annette Arnold, Margareta P. Correia, Manuel Winkler, Philipp-Sebastian Koch, Veronika Sexl, Thomas Höfer, Adelheid Cerwenka#. Single-cell RNA-seq reveals HIF-1α as a checkpoint for NK cell anti-tumor activity. Immunity,2020, 52(6), 1075-1087.e8.
5. Weike Pei*, Fuwei Shang*, Xi Wang*, Ann-Kathrin Fanti, Alessandro Greco, Katrin Busch, Kay Klapproth, Qin Zhang, Claudia Quedenau, Sascha Sauer, Thorsten Feyerabend, Thomas Höfer#, Hans-Reimer Rodewald#. Resolving fate and transcriptome of hematopoietic stem cell clones by PolyloxExpress Barcoding. Cell stem cell, 2020, 27(3): 383-395.e8 (封面文章)