Aves, Steve - University of Exeter - Disciplines of Biosciences

个人简介

I am a molecular biologist studying yeast and other micro-organisms. I have research interests in DNA replication, the cell division cycle and genome organisation, molecular and synthetic biology approaches applied to biofuel production in micro-organisms, and microbial consortia. I teach molecular genetics and I am Academic Lead for the Education group. Qualifications 2012 ASPIRE Senior Fellowship 2012 Senior Fellow of The Higher Education Academy 2002 SEDA Full Accreditation 1984 PhD Molecular Biology, University of Bristol 1979 BA (Hons) Biology, University of York Career 2006-present Associate Professor in Molecular Biology, School of Biosciences, University of Exeter 2004-2006 Senior Lecturer, School of Biosciences, University of Exeter 1986-2004 Lecturer, School of Biological Sciences, University of Exeter Summer 1987 Danish Research Academy Visiting Professor, Institute of Genetics, University of Copenhagen 1984-1986 Research Fellow, University of Sussex & Imperial Cancer Research Fund Laboratories, London

研究领域

DNA replication and genome organisation. Before a cell can divide it must first copy its genome, and even a small mistake in DNA replication can lead to a problem such as the production of a cell that can cause cancer. We investigate the DNA replication complex using molecular and genetic strategies, with cells of the fission yeast Schizosaccharomyces pombe as a model. Our research focuses on the essential Mcm10 initiation protein, its interactions with other DNA replication components, and the evolution of DNA replication components in eukaryotes. Microbial biofuel production. We are using molecular genetic, bioinformatic and synthetic biology methods to study biofuel production in micro-organisms as part of the Exeter Microbial Biofuels Group. Our particular interests are in oleaginous yeasts, and developing molecular genetic tools for researching, exploitation and metabolic engineering of these fungi. Microbial consortia. Micro-organisms frequently live in multi-species consortia, but the composition and interactions of these are often poorly understood. In collaboration with others, we use metagenomics and bioinformatic analysis to investigate microbial consortia associated with hydrocarbon generation and acid mine drainage.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Howard TP, Middelhaufe S, Moore K, Edner C, Kolak DM, Taylor GN, Parker DA, Lee R, Smirnoff N, Aves SJ, et al (In Press). Synthesis of customized petroleum-replica fuel molecules by targeted modification of free fatty acid pools in Escherichia coli. PNAS Abstract. Author URL. Jones KJ, Moore K, Sambles C, Love J, Studholme DJ, Aves SJ (2016). Draft Genome Sequences of Achromobacter piechaudii GCS2, Agrobacterium sp. Strain SUL3, Microbacterium sp. Strain GCS4, Shinella sp. Strain GWS1, and Shinella sp. Strain SUS2 Isolated from Consortium with the Hydrocarbon-Producing Alga Botryococcus braunii. Genome Announc, 4(1). Abstract. Author URL. Full text. Milne SW, Cheetham J, Lloyd D, Shaw S, Moore K, Paszkiewicz KH, Aves SJ, Bates S (2014). Role of Candida albicans Tem1 in mitotic exit and cytokinesis. Fungal Genet Biol, 69, 84-95. Abstract. Author URL. Full text. Article has an altmetric score of 2 Curtis BA, Tanifuji G, Burki F, Gruber A, Irimia M, Maruyama S, Arias MC, Ball SG, Gile GH, Hirakawa Y, et al (2012). Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs. Nature, 492(7427), 59-65. Abstract. Author URL. Article has an altmetric score of 84 King NC, Aves SJ (2012). Effect of A-level subject choice and entry tariff on final degree and level 1 performance in biosciences. Bioscience Education, 19 Abstract. Aves SJ, Liu Y, Richards TA (2012). Evolutionary diversification of eukaryotic DNA replication machinery. Subcell Biochem, 62, 19-35. Abstract. Author URL. Article has an altmetric score of 2 Milne SW, Cheetham J, Lloyd D, Aves S, Bates S (2011). Cassettes for PCR-mediated gene tagging in Candida albicans utilizing nourseothricin resistance. Yeast, 28(12), 833-841. Abstract. Author URL. Full text. Bryant JA, Aves SJ (2011). Initiation of DNA replication: functional and evolutionary aspects. Ann Bot, 107(7), 1119-1126. Abstract. Author URL. Article has an altmetric score of 4 Taylor M, Moore K, Murray J, Aves SJ, Price C (2011). Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1). DNA Repair, 10(11), 1154-1163. Full text. Saunders DG, Aves SJ, Talbot NJ (2010). Cell cycle-mediated regulation of plant infection by the rice blast fungus. Plant Cell, 22(2), 497-507. Abstract. Author URL. Full text. Liu Y, Richards TA, Aves SJ (2009). Ancient diversification of eukaryotic MCM DNA replication proteins. BMC Evol Biol, 9 Abstract. Full text. Aves SJ (2009). DNA replication initiation. Methods Mol Biol, 521, 3-17. Abstract. Author URL. Patch AM, Aves SJ (2007). Fingerprinting fission yeast: polymorphic markers for molecular genetic analysis of Schizosaccharomyces pombe strains. Microbiology, 153(Pt 3), 887-897. Abstract. Author URL. Boby T, Patch AM, Aves SJ (2005). TRbase: a database relating tandem repeats to disease genes for the human genome. Bioinformatics, 21(6), 811-816. Abstract. Author URL. Gregan J, Lindner K, Brimage L, Franklin R, Namdar M, Hart EA, Aves SJ, Kearsey SE (2003). Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding. Mol Biol Cell, 14(9), 3876-3887. Abstract. Author URL. Full text. Dambrauskas G, Aves SJ, Bryant JA, Francis D, Rogers HJ (2003). Genes encoding two essential DNA replication activation proteins, Cdc6 and Mcm3, exhibit very different patterns of expression in the tobacco BY-2 cell cycle. J Exp Bot, 54(383), 699-706. Abstract. Author URL. Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, et al (2003). The genome sequence of Schizosaccharomyces pombe (vol 415, pg 871, 2002). NATURE, 421(6918), 94-94. Author URL. Hart EA, Bryant JA, Moore K, Aves SJ (2002). Fission yeast Cdc23 interactions with DNA replication initiation proteins. Curr Genet, 41(5), 342-348. Abstract. Author URL. Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, et al (2002). The genome sequence of Schizosaccharomyces pombe. Nature, 415(6874), 871-880. Abstract. Author URL. Article has an altmetric score of 15 Aves SJ, Hunt C, Xiang Z, Lyne MH, Wood V, Rajandream MA, Skelton J, Churcher CM, Warren T, Harris D, et al (2002). The mei3 region of the Schizosaccharomyces pombe genome. Yeast, 19(6), 521-527. Abstract. Author URL.