Worrall, Jonathan - University of Essex - School of Biological Sciences

个人简介

2007-present: University of Essex, UK 2005-2007: Post-doctoral research associate, Department of Biochemistry, University of Cambridge, UK 1999-2005: Post-doctoral research associate, Leiden Institute of Chemistry, Leiden University, The Netherlands 1995-1999: PhD in Bioinorganic Chemistry, Department of Chemistry, Newcastle University, UK (Supervisor Professor A.G. Sykes FRS) 1992-1995: BSc (Hons) Medicinal Chemistry, Newcastle University, UK

研究领域

Microbial Biotechnology Copper homeostasis in Streptomyces Lipid induced apoptosis Structural Biochemistry

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

A.I. Karsisiotis, O.M. Deacon, M.T. Wilson, C. Macdonald, T.M.A. Blumenschein, G.R. Moore, J.A.R. Worrall (2016) "Increased dynamics in the 40-57 Ω-loop of the G41S variant of human cytochrome c promote its pro-apoptotic conformation" Scientific Reports 6, 30447. A.K. Chaplin, M.T. Wilson, M.A. Hough, D.A. Svistunenko, G.R. Hemsworth, P.H. Walton, E. Vijgenboom, J.A.R. Worrall (2016) "Heterogeneity in the histidine-brace copper coordination spehere in auxiliary activity family 10 (AA10) lytic polysaccharide monooxygenases" Journal of Biological Chemistry 291, 12838-12850. M.L.C. Petrus, E. Vijgenboom, A.K. Chaplin, J.A.R. Worrall, G.P. van Wezel, D. Claessen (2016) "The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces" Open Biology 6, 150149. T.V. Porto, M.T. Wilson, J.A.R. Worrall (2015) "Copper and nickel bind via two distinct kinetic mechanisms to a CsoR metalloregulator" Dalton Transactions 44, 20176-20185. T.V. Porto, M.A. Hough, J.A.R. Worrall (2015) "Structural insights into conformational switching in the copper metalloregulator CsoR from Streptomyces lividans" Acta Crystallographica D Biological Crystallography 71, 1872-1878. A.I. Karsisiotis, O.M. Deacon, B.S. Rajagopal, C. Macdonald, T.M.A. Blumenschein, G.R. Moore, J.A.R. Worrall (2015) "Backbone resonance assignments of ferric human cytochrome c and the pro-apoptotic G41S mutant in the ferric and ferrous states" Biomolecular NMR Assignments 9, 415-419. A.K. Chaplin, M.L. Petrus, G. Mangiameli, M.A. Hough, D.A. Svistunenko, P. Nicholls, D. Claessen, E. Vijgenboom, J.A.R. Worrall (2015) "GlxA is a new structural member of the radical copper oxidase family and is required for glycan deposition at hyphal tips and morphogenesis of Streptomyces lividans" Biochemical Journal 469, 433-444. A.K. Chaplin, B.G. Tan, E. Vijgenboom, J.A.R. Worrall (2015) " Copper trafficking in the CsoR regulon of Streptomyces lividans" Metallomics 7, 145-155. M.A. Hough, G. Silkstone, J.A.R. Worrall, M.T. Wilson (2014) "NO binding to the proapoptotic cytochrome c-cardiolipin complex" Vitamins and Hormones 96, 193-209. K.L.I.M. Blundell, M.A. Hough, E. Vijgenboom, J.A.R. Worrall (2014) "Structural and mechanistic insights into an extracytoplasmic copper trafficking pathway in Streptomyces lividans" Biochemical Journal 459, 525-538. B.G. Tan, E. Vijgenboom, J.A.R. Worrall (2014) "Conformational and thermodynamic hallmarks of DNA operator site specificity in the copper sensitive operon repressor from Streptomyces lividans" Nucleic Acids Research 42, 1326-1340. B.S. Rajagopal, A.N. Edzuma, M. A. Hough, K.L.I.M. Blundell, V.E. Kagan, A.A. Kapralov, L.A. Fraser, J.N. Butt, G.G. Silkstone, M.T. Wilson, D.A. Svistunenko, J.A.R. Worrall (2013) "The hydrogen peroxide induced radical behaviour in human cytochrome c phospholipid complexes: Implications for the enhanced pro-apoptotic activity of the G41S mutant" Biochemical Journal 456, 441-452. K.L.I.M. Blundell, M.T. Wilson, E. Vijgenboom, J.A.R. Worrall (2013) "The role of the Cys-X-X-X-Cys motif on the kinetics of cupric ion loading to the Streptomyces lividans Sco protein" Dalton Transactions 42, 10608-10616. K.L.I.M. Blundell, M.T. Wilson, D.A. Svistunenko, E. Vijgenboom, J.A.R. Worrall (2013) "Morphological development and cytochrome c oxidase activity in Streptomyces lividans are dependent on the action of a copper bound Sco protein" Open Biology 3, 120163. S. Dwarakanath, A.K. Chaplin, M.A. Hough, S. Rigali, E. Vijgenboom, J.A.R. Worrall (2012) “Response to copper stress in Streptomyces lividans extends beyond genes under direct control of a Copper sensitive operon Repressor protein (CsoR)” Journal of Biological Chemistry 287, 17833-17847. D.A. Svistunenko, J.A.R. Worrall, S.B. Chugh, S.C. Haigh, R.A. Ghiladi, P. Nicholls (2012) “Ferric haem forms of Mycobacterium tuberculosis catalase-peroxidase probed by EPR spectroscopy: Their stability and interplay with pH” Biochimie 94, 1274-1280. B.S. Rajagopal, G.G. Silkstone, P. Nicholls, M.T. Wilson, J.A.R. Worrall (2012) “An investigation into a cardiolipin acyl chain insertion site in cytochrome c” Biochimica et Biophysica Acta-Bioenergetics 1817, 780-791. J.M. Mason, D.S. Bendall, C.J. Howe, J.A.R. Worrall (2012) “The role of a disulfide bridge in the stability and folding kinetics of Arabidopsis thaliana cytochrome c6A” Biochimica et Biophysica Acta-Proteins and Proteomics 1824, 311-318. A.N. Volkov, P. Nicholls, J.A.R. Worrall (2011) The complex of cytochrome c and cytochrome c peroxidase: The end of the road? Biochimica et Biophysica Acta-Bioenergetics 1807, 1482-1503. B.S. Rajagopal, M.T. Wilson, D.S. Bendall, C.J. Howe, J.A.R. Worrall (2011) “Structural and kinetic studies of imidazole binding to two members of the cytochrome c6 family reveal an important role for a conserved heme pocket residue” Journal of Biological Inorganic Chemistry 16, 577-588.