Schalkwyk, Leonard - University of Essex - School of Biological Sciences

个人简介

Originally a microbiologist from Canada, Leo studied at the University of Alberta, graduating in 1983. His PhD (Dalhousie University, 1991) was on genome mapping of Haloferax, an archaeon from the Dead Sea. He worked on genomic resources for several species and genome mapping of mouse in Hans Lehrach’s laboratory at the Imperial Cancer Research Fund laboratory in London and at the Max-Planck-Institut für molekulare Genetik in Berlin. He was at the Social, Genetic and Developmental Psychiatry Research Centre, King’s College London from 2000-2014, where he worked on functional genomics and epigenomics, identifying genes involved in behaviour in the mouse and in depression, schizophrenia and Alzheimer’s disease in human. His research program is now widening to include environmental epigenetics ResearcherID

研究领域

Genomic and epigenomic methods and software Epigenomics and the environment Alzheimer's disease Schizophrenia

近期论文

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Malki, Karim and Tosto, Maria Grazia and Mouriño-Talín, Héctor and Rodríguez-Lorenzo, Sabela and Pain, Oliver and Jumhaboy, Irfan and Liu, Tina and Parpas, Panos and Newman, Stuart and Malykh, Artem and Carboni, Lucia and Uher, Rudolf and McGuffin, Peter and Schalkwyk, Leonard C and Bryson, Kevin and Herbster, Mark (2016) 'Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression.' American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. ISSN 1552-4841 Malki, Karim and Du Rietz, Ebba and Crusio, Wim and Pain, Oliver and Paya-Cano, Jose and Karadaghi, Rezhaw L and Sluyter, Frans and de Boer, Sietse F and Sandnabba, Kenneth and Schalkwyk, Leonard C and Asherson, Philip and Tosto, Maria Grazia (2016) 'Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish.' American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 (6). pp. 827-838. ISSN 1552-4841 Hannon, Eilis and Dempster, Emma and Viana, Joana and Burrage, Joe and Smith, Adam R and Macdonald, Ruby and St Clair, David and Mustard, Colette and Breen, Gerome and Therman, Sebastian and Kaprio, Jaakko and Toulopoulou, Timothea and Pol, Hilleke E Hulshoff and Bohlken, Marc M and Kahn, Rene S and Nenadic, Igor and Hultman, Christina M and Murray, Robin M and Collier, David A and Bass, Nick and Gurling, Hugh and McQuillin, Andrew and Schalkwyk, Leonard C and Mill, Jonathan (2016) 'An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation.' Genome Biology, 17 (1). ISSN 1474-760X Smith, Adam and Smith, Rebecca G and Condliffe, Daniel and Hannon, Eilis and Schalkwyk, Leonard C and Mill, Jonathan and Lunnon, Katie (2016) 'Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer’s disease brain.' Neurobiology of Aging. ISSN 0197-4580 Malki, Karim and Tosto, Maria G and Pain, Oliver and Sluyter, Frans and Mineur, Yann S and Crusio, Wim E and de Boer, Sietse and Sandnabba, Kenneth N and Kesserwani, Jad and Robinson, Edward and Schalkwyk, Leonard C and Asherson, Philip (2016) 'Comparative mRNA analysis of behavioral and genetic mouse models of aggression.' American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 (3). pp. 427-436. ISSN 1552-4841 Houtepen, Lotte C and Vinkers, Christiaan H and Carrillo-Roa, Tania and Hiemstra, Marieke and van Lier, Pol A and Meeus, Wim and Branje, Susan and Heim, Christine M and Nemeroff, Charles B and Mill, Jonathan and Schalkwyk, Leonard C and Creyghton, Menno P and Kahn, René S and Joëls, Marian and Binder, Elisabeth B and Boks, Marco P M (2016) 'Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans.' Nature Communications, 7. p. 10967. ISSN 2041-1723 Lunnon, Katie and Hannon, Eilis and Smith, Rebecca G and Dempster, Emma and Wong, Chloe and Burrage, Joe and Troakes, Claire and Al-Sarraj, Safa and Kepa, Agnieszka and Schalkwyk, Leonard C and Mill, Jonathan (2016) 'Variation in 5-hydroxymethylcytosine across human cortex and cerebellum.' Genome Biology, 17 (1). ISSN 1474-760X Marzi, Sarah J and Meaburn, Emma L and Dempster, Emma L and Lunnon, Katie and Paya-Cano, Jose L and Smith, Rebecca G and Volta, Manuela and Troakes, Claire and Schalkwyk, Leonard C and Mill, Jonathan (2016) 'Tissue-specific patterns of allelically-skewed DNA methylation.' Epigenetics, 11 (1). pp. 24-35. ISSN 1559-2294 Spiers, H and Bray, N J and Hannon, E and Schalkwyk, Leonard C and Wong, C C and Pidsley, R and Smith, R G and Mill, J (2015) 'Dynamic and sex-specific changes in DNA methylation during human fetal brain development.' International Journal of Developmental Neuroscience, 47 (Pt A). pp. 50-51. ISSN 0736-5748 Carter, Kim W and Francis, Richard W and Bresnahan, M and Gissler, M and Grønborg, R and Gunnes, N and Hammond, G and Hornig, M and Hultman, C M and Huttunen, J and Langridge, A and Leonard, H and Newman, S and Parner, E T and Petersson, G and Reichenberg, A and Sandin, S and Schendel, D E and Schalkwyk, Leonard C and Sourander, A and Steadman, C and Stoltenberg, C and Suominen, A and Surén, P and Susser, E and Sylvester Vethanayagam, A and Yusof, Z (2015) 'ViPAR: a software platform for the Virtual Pooling and Analysis of Research Data.' International Journal of Epidemiology. ISSN 0300-5771 Janecka, Magdalena and Manduca, Antonia and Servadio, Michela and Trezza, Viviana and Smith, Rebecca and Mill, Jonathan and Schalkwyk, Leonard C and Reichenberg, Avi and Fernandes, Cathy (2015) 'Effects of advanced paternal age on trajectories of social behavior in offspring.' Genes, Brain and Behavior, 14 (6). pp. 443-453. ISSN 1601-1848 Spiers, Helen and Hannon, Eilis and Schalkwyk, Leonard C and Smith, Rebecca and Wong, Chloe C Y and O'Donovan, Michael C and Bray, Nicholas J and Mill, Jonathan (2015) 'Methylomic trajectories across human fetal brain development.' Genome Research. ISSN 1088-9051 Boks, Marco P and Mierlo, Hans C van and Rutten, Bart P F and Radstake, Timothy . D J and De Witte, Lot and Geuze, Elbert and Horvath, Steve and Schalkwyk, Leonard C and Vinkers, Christiaan H and Broen, Jasper . A and Vermetten, Eric (2015) 'Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder.' Psychoneuroendocrinology, 51. pp. 506-512. ISSN 0306-4530 Elliott, GiNell and Hong, Chibo and Xing, Xiaoyun and Zhou, Xin and Li, Daofeng and Coarfa, Cristian and Bell, Robert J A and Maire, Cecile L and Ligon, Keith L and Sigaroudinia, Mahvash and Gascard, Philippe and Tlsty, Thea D and Harris, R Alan and Schalkwyk, Leonard C and Bilenky, Misha and Mill, Jonathan and Farnham, Peggy J and Kellis, Manolis and Marra, Marco A and Milosavljevic, Aleksandar and Hirst, Martin and Stormo, Gary D and Wang, Ting and Costello, Joseph F (2015) 'Intermediate DNA methylation is a conserved signature of genome regulation.' Nature Communications, 6. p. 6363. ISSN 2041-1723 Hannon, Eilis and Lunnon, Katie and Schalkwyk, Leonard C and Mill, Jonathan (2015) 'Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes.' Epigenetics, 10 (11). pp. 1024-1032. ISSN 1559-2294 Hannon, Eilis and Spiers, Helen and Viana, Joana and Pidsley, Ruth and Burrage, Joe and Murphy, Therese M and Troakes, Claire and Turecki, Gustavo and O'Donovan, Michael C and Schalkwyk, Leonard C and Bray, Nicholas J and Mill, Jonathan (2015) 'Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci.' Nature Neuroscience, 19. pp. 48-54. ISSN 1097-6256 Malki, K and Pain, O and Tosto, M G and Du Rietz, E and Carboni, L and Schalkwyk, Leonard C (2015) 'Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes.' Translational Psychiatry, 5 (3). e518. ISSN 2158-3188 Malki, Karim and Mineur, Yann S and Tosto, Maria Grazia and Campbell, James and Karia, Priya and Jumabhoy, Irfan and Sluyter, Frans and Crusio, Wim E and Schalkwyk, Leonard C (2015) 'Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains.' BMC Genomics, 16 (1). ISSN 1471-2164 Pidsley, Ruth and Viana, Joana and Hannon, Eilis and Spiers, Helen H and Troakes, Claire and Al-Saraj, Safa and Mechawar, Naguib and Turecki, Gustavo and Schalkwyk, Leonard C and Bray, Nicholas J and Mill, Jonathan (2014) 'Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.' Genome Biology, 15 (10). p. 483. ISSN 1465-6906 Bell, J T and Loomis, A K and Butcher, L M and Gao, F and Zhang, B and Hyde, C L and Sun, J and Wu, H and Ward, K and Harris, J and Scollen, S and Davies, M N and Schalkwyk, Leonard C and Mill, J and Williams, F M K and Li, N and Deloukas, P and Beck, S and McMahon, S B and Wang, J and John, S L and Spector, t d (2014) 'Differential methylation of the TRPA1 promoter in pain sensitivity.' Nature Communications, 5. p. 2978. ISSN 2041-1723