Reynolds, Christopher A. - University of Essex - School of Biological Sciences

个人简介

2000 - present Professor, Department of Biological Sciences, University of Essex 1998-2000 Reader, Department of Biological Sciences, University of Essex 1991-1997 Lecturer, Department of Chemistry and Biological Chemistry, University of Essex 1985-1991 PDRA, Laboratory of Physical Chemistry and Oxford Centre for Molecular Sciences, University of Oxford - under Prof. W. Graham Richards 1982-1985 PhD in Computational Chemistry, University of St. Andrews - under Dr. Colin Thomson 1979-1982 Research Chemist, British Steel 1975-1979 1st class BSc (Honours) Chemistry, University of St. Andrews Professional qualifications: CChem, FRSC

研究领域

Molecular Modelling Computational Chemistry The development of methods in computational chemistry and bioinformatics and their application to problems in chemistry and biology. Modelling polarization through induced charges Fragment-based drug design Modelling G-protein coupled receptor structure and activation (Class A and Class B) Assessing the role of closed loops in protein folding Developing software for molecular modelling (see group web pages)

近期论文

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1. Wootten, D.; Reynolds, C. A.; Koole, C.; Smith, K. J.; Mobarec, J. C.; Quon, T.; Coudrat, T.; Furness, S. G. B.; Miller, L. J.; Christopoulos, A.; Sexton, P. M. A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structures. Mol. Pharmacol. 2016, 89, 335-347. 2. Weston, C.; Lu, J.; Li, N.; Barkan, K.; Richards, G. O.; Roberts, D. J.; Skerry, T. M.; Poyner, D.; Pardamwar, M.; Reynolds, C. A.; Dowell, S. J.; Willars, G. B.; Ladds, G. Modulation of Glucagon Receptor Pharmacology by RAMP2. The Journal of biological chemistry 2015, 290, 23009-23022. 3. Taddese, B.; Upton, G. J.; Bailey, G. R.; Jordan, S. R.; Abdulla, N. Y.; Reeves, P. J.; Reynolds, C. A. Do plants contain G protein-coupled receptors? Plant Physiol 2014, 164, 287-307. 4. Roy, A.; Taddese, B.; Vohra, S.; Thimmaraju, P. K.; Illingworth, C. J.; Simpson, L. M.; Mukherjee, K.; Reynolds, C. A.; Chintapalli, S. V. Identifying subset errors in multiple sequence alignments. J Biomol.Struct.Dyn. 2014, 32, 364-371. 5. Lock, A.; Forfar, R.; Weston, C.; Bowsher, L.; Upton, G. J.; Reynolds, C. A.; Ladds, G.; Dixon, A. M. One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs. Biochim.Biophys.Acta 2014, 1838, 3036-3051. 6. Chintapalli, S. V.; Illingworth, C. J.; Upton, G. J.; Sacquin-Mora, S.; Reeves, P. J.; Mohammedali, H. S.; Reynolds, C. A. Assessing the effect of dynamics on the closed-loop protein-folding hypothesis. J R Soc Interface 2014, 11, 20130935. 7. Woolley, M. J.; Watkins, H. A.; Taddese, B.; Karakullukcu, Z. G.; Barwell, J.; Smith, K. J.; Hay, D. L.; Poyner, D. R.; Reynolds, C. A.; Conner, A. C. The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach. J R.Soc Interface 2013, 10, 20130589. 8. Vohra, S.; Taddese, B.; Conner, A. C.; Poyner, D. R.; Hay, D. L.; Barwell, J.; Reeves, P. J.; Upton, G. J.; Reynolds, C. A. Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. J R.Soc Interface 2013, 10, 20120846. 9. Taddese, B.; Simpson, L. M.; Wall, I. D.; Blaney, F. E.; Reynolds, C. A. Modeling active GPCR conformations. Methods Enzymol. 2013, 522, 21-35. 10. Opefi, C. A.; South, K.; Reynolds, C. A.; Smith, S. O.; Reeves, P. J. Retinitis Pigmentosa Mutants Provide Insight into the Role of the N-terminal Cap in Rhodopsin Folding, Structure, and Function. The Journal of biological chemistry 2013, 288, 33912-26. 11. Illingworth, C. J. R.; Chintapalli, S. V.; Serapian, S. A.; Miller, A. D.; Veverka, V.; Carr, M. D.; Reynolds, C. A. The Statistical Significance of Selected Sense-Antisense Peptide Interactions (vol 33, pg 1440, 2012). Journal of computational chemistry 2013, 34, 256-256. 12. Barwell, J.; Wheatley, M.; Conner, A. C.; Taddese, B.; Vohra, S.; Reynolds, C. A.; Poyner, D. R. The activation of the CGRP receptor. Biochemical Society transactions 2013, 41, 180-184. 13. Taddese, B.; Simpson, L. M.; Wall, I. D.; Blaney, F. E.; Kidley, N. J.; Clark, H. S.; Smith, R. E.; Upton, G. J.; Gouldson, P. R.; Psaroudakis, G.; Bywater, R. P.; Reynolds, C. A. G-protein-coupled receptor dynamics: dimerization and activation models compared with experiment. Biochem Soc.Trans 2012, 40, 394-399. 14. Illingworth, C. J. R.; Chintapalli, S. V.; Serapian, S. A.; Miller, A. D.; Veverka, V.; Carr, M. D.; Reynolds, C. A. The statistical significance of selected sense-antisense peptide interactions. J.Comput.Chem. 2012, 33, 1440-1447. 15. Illingworth, C. J.; Chintipalli, S. V.; Serapian, S. A.; Miller, A. D.; Veverka, V.; Carr, M. D.; Reynolds, C. A. The statistical significance of selected sense-antisense peptide interactions. Journal of computational chemistry 2012, 33, 1440-7. 16. Simpson, L. M.; Wall, I. D.; Blaney, F. E.; Reynolds, C. A. Modeling GPCR active state conformations: the beta(2)-adrenergic receptor. Proteins 2011, 79, 1441-1457. 17. Simpson, L. M.; Taddese, B.; Wall, I. D.; Reynolds, C. A. Bioinformatics and molecular modelling approaches to GPCR oligomerization. Curr.Opin.Pharmacol. 2010, 10, 30-37. 18. Illingworth, C. J.; Scott, P. D.; Parkes, K. E.; Snell, C. R.; Campbell, M. P.; Reynolds, C. A. Connectivity and binding-site recognition: applications relevant to drug design. J Comput.Chem 2010, 31, 2677-2688. 19. Chintapalli, S. V.; Yew, B. K.; Illingworth, C. J.; Upton, G. J.; Reeves, P. J.; Parkes, K. E.; Snell, C. R.; Reynolds, C. A. Closed loop folding units from structural alignments: experimental foldons revisited. Journal of computational chemistry 2010, 31, 2689-701. 20. Vickers, A. J.; Ma, Y.; Dudley, R.; Reeves, P. J.; Reynolds, C. A.; Gadde, S. THz differential spectroscopy of rhodopsin. 2008 33rd International conference on infrared, millimeter and terahertz waves, Vols 1, 2 2008, 851-852.