Madapura, Pradeepa M - University of Essex - School of Biological Sciences

个人简介

2016 – : Lecturer at the University of Essex, Colchester, UK 2009 – 2015: Postdoctoral Fellow in the laboratory of Prof Wendy Bickmore, Medical Research Council - Human Genetics Unit, University of Edinburgh, UK PREVIOUS POSITIONS AND RESEARCH EXPERIENCE 2004 – 2009: PhD Student with Prof. MRS Rao, JNCASR, Bangalore, India. 2001 – 2003: Post graduate research student (MSc Biochemistry), UAS, Bangalore, India. FELLOWSHIPS / AWARDS 2016 – 2017 : Wellcome Trust Seed Award 2012 – 2013 : Medical Research Council - Centenary award 2009 : Best PhD thesis medal in biological sciences from JNCASR, Bangalore 2008 : Best poster award in conference on “Chromosome-Chromatin Dynamics” at Bangalore.

研究领域

Mechanisms in regulation of gene expression Role of Histone modifications Enhancers, Distal regulation of gene expression

近期论文

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Pradeepa MM*, Taylor G, Grimes G R, Wood A, Bickmore WA* Psip1/p52 regulates distal Hoxa genes through activation of lncRNA Hottip BioRxiv doi: http://dx.doi.org/10.1101/061192 Pradeepa M M*, Grimes G R, Kumar Y, Olley G, Taylor G, Schneider R and Bickmore W A*. Histone H3 globular domain acetylations identifes novel enhancers Nature Genet. 2016 Pradeepa M M*, Grimes G, Taylor G, Sutherland H & Bickmore W A*. (2014) Psip1/p75 restrains expression of Hox genes by recruiting both trithorax and polycomb proteins Nucleic Acid Res. DOI: 10.1093/nar/gku647. Taylor G, Eskeland R. Balkan B H, Pradeepa M M* & Bickmore W A*. (2013) H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction. Genome Res. doi: 10.1101/gr.155028.113. Pradeepa, M M., Sutherland, H. G., Ule, J., Grimes, G. R., & Bickmore, W. A. (2012). Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing. PLoS genetics, 8(5), e1002717. doi:10.1371 Pradeepa M M, Nikhil G, Hari Kishore A, Bharath GN, Kundu TK, & Rao MR. (2009) Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3. J Biol Chem. 284(43):29956-67.