Metodiev, Metodi - University of Essex - School of Biological Sciences

个人简介

Oct 2011-present - Senior Lecturer, University of Essex Nov 2004-Oct 2011- Lecturer in Proteomics, University of Essex, UK Jan 2002-Nov 2004 - Research Assistant Professor, University of Illinois at Chicago, Laboratory for Molecular Biology Sept 1999-Jan 2002 - Visiting Research Assistant Professor, University of Illinois at Chicago, Laboratory for Molecular Biology Jul 1998-Jun 1999 - Senior Research Scientist, University of the North, Qwa-Qwa Campus, South Africa 1994-1998 - Research Scientist, Bulgarian Academy of Sciences, Sofia, Bulgaria 1992-1994 - Research Associate, Bulgarian Academy of Sciences, Sofia Bulgaria 1994 - Ph.D.: Biological Sciences (Protein Biochemistry), Bulgarian Academy of Sciences 1989 - M.Sc.: Biology, Sofia State University

研究领域

cell signalling proteins proteomics biological mass spectrometry cancer biology

近期论文

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Harrod A, Fulton J, Nguyen VT, Periyasamy M, Ramos-Garcia L, Lai CF, Metodieva G, de Giorgio A, Williams RL, Santos DB, Gomez PJ, Lin ML, Metodiev MV, Stebbing J, Castellano L, Magnani L, Coombes RC, Buluwela L, Ali S. 2016. Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. Oncogene. 2016 Oct 17. doi: 10.1038/onc.2016.382. PubMed PMID: 27748765. Metodieva G, Adoki S, Lausen B, Metodiev MV*. 2016. Decreased usage of specific SCRIB exons defines a more malignant phenotype of breast cancer with worsened survival. eBioMedicine, in press, doi: 10.1016/j.ebiom.2016.05.009. Amber Ismael, Wei Tian, Nicholas Waszczak, Xin Wang, Youfang Cao, Dmitry Suchkov, Eli Bar, Metodi V Metodiev, Jie Liang, Robert A Arkowitz, David E Stone. 2016. Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation. Science Signaling 9 (423), ra38-ra38. Roland S. Croner, Müzeyyen Sevim, Metodi V. Metodiev, Peter Jo, Michael Ghadimi, Vera Schellerer, Maximillian Brunner, Carol Geppert, Tilman Rau, Michael Stürzl, Elisabeth Naschberger, Klaus Matzel, Werner Hohenberger, Friedrich Lottspeich, Josef Kellermann. 2016. Identification of predictive markers for response to neoadjuvant chemoradiation in rectal carcinomas by proteomic isotope coded protein label (ICPL) analysis. International Journal of Molecular Sciences (IJMS), in press. O Mahmoud, A Harrison, A Gul, Z Khan, MV Metodiev, B Lausen. 2016. Minimizing Redundancy Among Genes Selected Based on the Overlapping Analysis. Analysis of Large and Complex Data, 275-285. Metodiev MV*, UEE Ltd. 2016. Detection and treatment of cancer. US Patent 9,310,371. Harabedyan S, Todorova K, Jabeen A, Metodieva G, Toshkov S , Metodiev MV, Mincheff M, Fernandez N. 2016. Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production. Scientific Reports, in press. Todorova, K., Metodiev, M. V., Metodieva, G., Zasheva, D., Mincheff, M. and Hayrabedyan, S. 2016, miR-204 is dysregulated in metastatic prostate cancer in vitro. Mol. Carcinog., 55: 131–147. doi:10.1002/mc.22263 Mock, T., Daines, S. J., Geider, R., Collins, S., Metodiev, M., Millar, A. J., Moulton, V. and Lenton, T. M. 2016, Bridging the gap between omics and earth system science to better understand how environmental change impacts marine microbes. Glob Change Biol, 22: 61–75. Boyd A McKew, Gergana Metodieva, Christine A Raines, Metodi V Metodiev, Richard J Geider. 2015. Acclimation of Emiliania huxleyi (1516) to nutrient limitation involves precise modification of the proteome to scavenge alternative sources of N and P. Environmental microbiology, 17 (10), 4050-4062. Mahmoud O, Harrison A, Perperoglou A, Gul A, Khan Z, Metodiev MV, Lausen B. 2014. A feature selection method for classification within functional genomics experiments based on the proportional overlapping score. BMC Bioinformatics. 2014 Aug 11;15:274. doi: 10.1186/1471-2105-15-274. Croner, R. S., Stürzl, M., Rau, T. T., Metodieva, G., Geppert, C. I., Naschberger, E., Lausen, B. and Metodiev, M. V*. 2014. Quantitative proteome profiling of lymph node-positive vs. -negative colorectal carcinomas pinpoints MX1 as a marker for lymph node metastasis. Int. J. Cancer. Dec 15;135(12):2878-86. doi: 10.1002/ijc.28929. Gergana Metodieva, Naiara Correa Nogueira-de-Souza, Christina Greenwood, Khalid Al-Janabi, Lin Leng, Richard Bucala, and Metodi V. Metodiev*. 2013. CD74-dependent deregulation of the tumor suppressor Scribble in human epithelial and breast cancer cells. Neoplasia, 15(6), 660-668. Nikolaos Parisis, Gergana Metodieva, Metodi V. Metodiev*. 2013. Pseudopodial and beta-arrestin-interacting proteomes from migrating breast cancer cells upon PAR2 activation. Journal of Proteomics, 80(3), 91-106. Reagan DeFlorio, Marie-Elena Brett, Nicholas Waszczak, Elisabetta Apollinari, Metodi V Metodiev, Oleksii Dubrovskyi, David Eddington, Robert A Arkowitz, David E Stone. 2013. Gβ phosphorylation is critical for efficient chemotropism in yeast. Journal of Cell Science, 15;126(Pt 14):2997-3009 Boyd A McKew, Stephane C Lefebvre, Eric P Achterberg, Gergana Metodieva, Christine A Raines, Metodi V Metodiev*, Richard J Geider. 2013. Plasticity in the proteome of Emiliania huxleyi CCMP 1516 to extremes of light is highly targeted. New Phytologist, 200(1), 61-73. *Joint corresponding author. Boyd A McKew, Phillip Davey, Stewart J Finch, Jason Hopkins, Stephane C Lefebvre, Metodi V Metodiev, Kevin Oxborough, Christine A Raines, Tracy Lawson, Richard J Geider. 2013. The trade-off between light-harvesting and photoprotective functions of fucoxanthin-chlorophyll proteins dominates light acclimation in Emiliania huxleyi (clone CCMP 1516). New Phytologist, 200(1), 74-85. Ioannis Karakikes, Ian E. G. Morrison, Peter O’Toole, Gergana Metodieva, Cristina V. Navarrete, Jesus Gomez, Jose M. Miranda-Sayago, Richard J. Cherry, Metodi Metodiev, and Nelson Fernandez. 2012. Interaction of HLA-DR and CD74 at the cell surface of antigen presenting cells by single particle image analysis. FASEB Journal, 26 (12), 4886-4896. Greenwood, C., Metodieva, G., Lausen, B., Alldridge, L., Al-Janabi, K., Leng, L., Bucala, R., Fernandez, N, and Metodiev, MV*. 2012. Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer. Journal of Proteomics, 75(10), 3031-40. Metodiev MV*. 2011. Biomarkers research in Europe: focus on personalized medicine. Expert Rev Mol Diagn. 11(7): 689-90.