Klenova, Elena - University of Essex - School of Biological Sciences

个人简介

I joined the Department of Biological Sciences in January 2001 as a Lecturer in Molecular Biology. My education: I graduated from the Moscow State University with the M.Sc. degree in Virology in 1982 and obtained my D.Phil. degree in Genetics at The Institute of General Genetics of the USSR Academy of Science in 1988. My research experience: 1996 – 2000 - Departmental Lecturer at the Genetics Unit, Department of Biochemistry, University of Oxford. 1992 - 1996 - Fellow of the European Molecular Biology Organization (EMBO) and International Human Frontier Science Program ( HFSPO ) Long-Term Fellowships at the Institute of Cancer Research, London. 1989-1991 Senior Research Fellow, Institute of Carcinogenesis, All-Union Cancer Research Center, Moscow, USSR. 1982-1989 Junior Research Fellow, The Institute of General Genetics, All-Union Academy of Science, Moscow, USSR.

研究领域

My main research interests lie in the areas of regulation of transcription and molecular mechanisms of tumourigenesis. We study the biological role of two related proteins, CTCF and BORIS, in genetics, epigenetics and disease, particularly, in tumourigenesis. CTCF and BORIS belong to a group of Zinc Finger transcription factors and share an identical DNA binding domain. Although related, CTCF and BORIS have different functions. CTCF has properties of a tumour suppressor, whereas BORIS has features of an oncogene. CTCF is present in various cell types, whereas BORIS normally is found only in the testis. Importantly, BORIS is activated in many cancers and could potentially be used as cancer biomarker. My research projects have been funded by various granting bodies, which include Councils and Charities such as The Medical Research Council (MRC), The Wellcome Trust, BBSRC, Association for International Cancer Research, Breast Cancer Campaign, Association for International Cancer Research, Breast Cancer Research Trust, NHS and others. I would be very interested to receive enquiries concerning research opportunities in my laboratory from D.Phil. students, Visiting and Post-Doctoral Scientists.

近期论文

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Cheema Z, Hari Y, Kita G-X, Farrar D, Seddon I, Corr J, Klenova E (2014) Expression of the cancer-testis antigen BORIS correlates with prostate cancer Prostate, 74(2):164-76. Méndez-Catalá CF, Gretton S, Vostrov A, Pugacheva E, Farrar D, Ito Y, Docquier F, Kita G-X, Murrell A, Lobanenkov V, Klenova E (2013) A novel mechanism for CTCF in the epigenetic regulation of Bax in breast cancer cells. Neoplasia, 15(8):898-912. Guastafierro T, Catizone A, Calabrese R, Zampieri M, Martella O, Bacalini MG, Reale A, Di Girolamo M, Miccheli M, Farrar D, Klenova E, Ciccarone F, Caiafa P. (2013) ADP-ribose polymer depletion leads to nuclear Ctcf re-localization and chromatin rearrangement. Biochem J. 449(3):623-30. Farrar D, Chernukhin I, Klenova E. (2011) Generation of poly(ADP-ribosyl)ation deficient mutants of the transcription factor, CTCF. Methods Mol Biol. 780:293-312. Farrar D, Chernukhin I, Klenova E (2011) Generation of poly(ADP-ribosyl)ation deficient mutants of the transcription factor, CTCF. Methods in Molecular Biology (2011),780:293-312. Chernukhin I, Kang SY, Brown S, Gretton S, Mendez-Catala CF, Cowieson D, Klenova E. (2011) BioVyon Protein A, an alternative solid-phase affinity matrix for chromatin immunoprecipitation. Anal Biochem. 412:183-8. Farrar D, Rai S, Chernukhin I, Jagodic M, Ito Y, Yammine S, Ohlsson R, Murrell A, Klenova E (2010) Mutational analysis of the poly(ADP-ribosy)lation sites of the transcription factor CTCF provides an insight into the mechanism of CTCF regulation by poly(ADP-ribosy)lation. Mol Cell Biology, 30(5):1199-216. Ohlsson R, Lobanenkov V, Klenova E. (2010) Does CTCF mediate between nuclear organization and gene expression? BioEssays, 32(1):37-50. Ali FR, Vasiliou AS, Haddley K, Paredes UM, Roberts JC, Miyajima F, Klenova E, Bubb VJ, Quinn JP (2009) Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF. Journal of Neurochemistry, 112(1):296-306. Docquier F, Kita G-X, Farrar D, Jat P, O’Hare M, Chernukhin I, Gretton S, Mandal A, Alldridge L, Klenova E (2009) Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation. Clinical Cancer Research, 15, 5762-71. Klenova E, Loukinov D, Lobanenkov V (2009) Essay on CTCF. Encyclopedia of Cancer, 2nd Edition, Springer. Loukinov D, Klenova E, Lobanenkov V (2009) Essay on BORIS. Encyclopedia of Cancer, 2nd Edition, Springer. Ito Y, Koessler T, Ibrahim AE, Rai S, Vowler SL, Abu-Amero S, Silva AL, Maia AT, Huddleston JE, Uribe-Lewis S, Woodfine K, Jagodic M, Nativio R, Dunning A, Moore G, Klenova E, Bingham S, Pharoah PD, Brenton JD, Beck S, Sandhu MS, Murrell A (2008) Somatically Acquired Hypomethylation of IGF2 in Breast and Colorectal Cancer. Hum Mol Genet.17(17):2633-43. D’Arcy V, Pore N, Docquier F, Abdullaev Z, Chernukhin I, Kita G-X, Rai S, Smart M, Farrar D, Pack S, Lobanenkov V, Klenova E (2008) BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours. British J Cancer, 98(3):571-9. Roberts J, Scott AC, Howard MR, Breen G, Bubb VJ, Klenova E*, Quinn JP* (2007) Differential regulation of the serotonin transporter gene by lithium is mediated by transcription factors, CTCF and YB-1, through the polymorphic intron 2 VNTR. J Neuroscience 27:2793-801. (*corresponding authors) Chernukhin I, Shamsuddin S, Kang SY, Bergström R, Kwon Y-W, WenQiang Yu WQ, Whitehead J, Mukhopadhyay R, Docquier F, Farrar D, Morrison I, Vigneron M, Wu S-Y, Chiang C-M, Loukinov D, Lobanenkov V, Ohlsson R, Klenova E (2007) CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide. Mol Cell Biol 27, 1631-1648. Hancock A, Brown KW, Moorwood K, Moon H, Holmgren C, Mardikar SH, Klenova E, Loukinov D, Ohlsson R, Lobanenkov V, Malik K (2007) A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS, and exhibits sequential epigenetic defects during wilms’ tumourigenesis. Hum Mol Genet. 16:343-54. D'Arcy V, Abdullayev Z, Pore N, Docquier F, Torrano V, Chernukhin IV, Smart M, Farrar D, Metodiev M, Fernandez N, Richard C, Delgado D, Lobanenkov V, Klenova E. (2006) BORIS, the CTCF-paralogous transcriptional factor is detected in the leukocytes of breast cancer patients and has potential as an early marker of tumourigenesis.Clinical Cancer Research, 12, 5978-5986. Torrano V, Navascués J., Docquier F, Zhang R, Burke L, Chernukhin I, Farrar D, León J, Berciano MT, Renkawitz R, Klenova E, Lafarga M, Delgado DM (2006) Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism. J Cell Science, 119, 1746-1759. Torrano V, Chernukhin I, Docquier F, D’Arcy V, Leon J, Klenova E*, Delgado D*. (2005) CTCF regulates growth and erythroid differentiation of human myeloid leukemia cells. J Biol Chem 280,28152-61 (*corresponding authors)