Hough, Mike - University of Essex - School of Biological Sciences

个人简介

BSc (Hons) Physics 1995 PhD Structural Biology 1999 Fellow of the Higher Education Academy Member of the Royal Society of Chemistry (MRSC) and Member of the Institute of Physics (MInstP) Member of the Biochemical Society, the British Crystallographic Association and the Inorganic Biochemistry Discussion Group of the RSC.

研究领域

High resolution structural biology (X-ray crystallography) of metalloproteins Combinined crystallography and spectroscopy (UV-visible absorption, resonance Raman and EPR) to understand the ligand-binding and redox properties of metal centres in proteins, primarily copper and haem systems. Kinetic crystallography using X-ray driven reaction initiation. Structural and functional studies of the gas sensing haemoprotein class, the cytochromes c' and their fascinating ability to discriminate between the small gaseous ligands NO and CO by binding them to opposite faces of haem while discriminating against oxygen binding. Protein structure and function Biotechnology Enzymes from the bacterial denitrification pathway (part of the global nitrogen cycle), principally Cu-containing nitrite reductase (NiR).

近期论文

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Brooke, Greg N and Gamble, Simon C and Hough, Michael A and Begum, Shajna and Dart, D Alwyn and Odontiadis, Michael and Powell, Sue M and Fioretti, Flavia M and Bryan, Rosie A and Waxman, Jonathan and Wait, Robin and Bevan, Charlotte L (2015) 'Antiandrogens act as selective androgen receptor modulators at the proteome level in prostate cancer cells.' Molecular & Cellular Proteomics. mcp.M113.036764. ISSN 1535-9476 Chaplin, Amanda K and Petrus, Marloes L C and Mangiameli, Giulia and Hough, Michael A and Svistunenko, Dimitri A and Nicholls, Peter and Claessen, Dennis and Vijgenboom, Erik and Worrall, Jonathan A R (2015) 'GlxA is a new structural member of the radical copper oxidase family and is required for glycan deposition at hyphal tips and morphogenesis ofStreptomyces lividans.' The Biochemical journal, 469 (3). pp. 433-444. Dworkowski, Florian S N and Hough, Michael A and Pompidor, Guillaume and Fuchs, Martin R (2015) 'Challenges and solutions for the analysis of in situ, in crystallomicro-spectrophotometric data.' Acta crystallographica. Section D, Biological crystallography, 71 (1). pp. 27-35. Ghafoor, Dlzar D and Kekilli, Demet and Abdullah, Gaylany H and Dworkowski, Florian S N and Hassan, Hamid G and Wilson, Michael T and Strange, Richard W and Hough, Michael A (2015) 'Hydrogen bonding of the dissociated histidine ligand is not required for formation of a proximal NO adduct in cytochrome c’.' Journal of Biological Inorganic Chemistry, 20 (6). pp. 949-956. Porto, Tatiana V and Hough, Michael A and Worrall, Jonathan A R (2015) 'Structural insights into conformational switching in the copper metalloregulator CsoR fromStreptomyces lividans.' Acta crystallographica. Section D, Biological crystallography, 71 (9). pp. 1872-1878. Servid, Amy E and McKay, Alison L and Davis, Cherry A and Garton, Elizabeth M and Manole, Andreea and Dobbin, Paul S and Hough, Michael A and Andrew, Colin R (2015) 'Resonance Raman Spectra of Five-Coordinate Heme-Nitrosyl Cytochromesc′: Effect of the Proximal Heme-NO Environment.' Biochemistry, 54 (21). pp. 3320-3327. Barrier, Elise and Braz Fernandes, Francisco Manuel and Bujan, Maya and Feiters, Martin C and Froideval, Annick and Ghijsen, Jacques and Hase, Thomas and Hough, Michael A and Jergel, Matej and Jimenez, Ignacio and Kajander, Tommi and Kikas, Arvo and Kokkinidis, Michael and Kover, Laszlo and Larsen, Helge B and Lawson, David Mark and Lawniczak-Jablonska, Krystyna and Mariani, Carlo and Mikulik, Petr and Monnier, Judith and Morera, Solange and McGuinness, Cormac and Müller-Buschbaum, Peter and Meedom Nielson, Martin and Pietsch, Ullrich and Tromp, Moniek and Simon, Marc and Stangl, Julian and Zanotti, Giuseppe (2014) 'The benefit of the European User Community from transnational access to national radiation facilities.' Journal of synchrotron radiation, 21 (Pt 3). pp. 638-9. Blundell, Katie L I M and Hough, Michael A and Vijgenboom, Erik and Worrall, Jonathan A R (2014) 'Structural and mechanistic insights into an extracytoplasmic copper trafficking pathway in Streptomyces lividans.' The Biochemical journal, 459 (3). pp. 525-38. Hough, Michael A and Silkstone, Gary and Worrall, Jonathan A R and Wilson, Michael T (2014) 'NO Binding to the Proapoptotic Cytochrome c–Cardiolipin Complex.' In: Litwack, Gerald, (ed.) Nitric Oxide. Vitamins and Hormones (96). Elsevier, Burlington, pp. 193-209. Kekilli, Demet and Dworkowski, Florian S N and Pompidor, Guillaume and Fuchs, Martin R and Andrew, Colin R and Antonyuk, Svetlana and Strange, Richard W and Eady, Robert R and Hasnain, S Samar and Hough, Michael A (2014) 'Fingerprinting redox and ligand states in haemprotein crystal structures using resonance Raman spectroscopy.' Acta crystallographica. Section D, Biological crystallography, 70 (Pt 5). pp. 1289-96. Reeder, Brandon J and Hough, Michael A (2014) 'The structure of a class 3 nonsymbiotic plant haemoglobin from Arabidopsis thaliana reveals a novel N-terminal helical extension.' Acta crystallographica. Section D, Biological crystallography, 70 (Pt 5). pp. 1411-8. Rajagopal, Badri and Edzuma, Ann and Hough, Michael A and Blundell, Katie and Kagan, Valerian and Kapralov, Alexandr and Fraser, Lewis and Butt, Julea and Silkstone, Gary and Wilson, Michael and Svistunenko, Dimitri A and Worrall, Jonathan A R (2013) 'The hydrogen peroxide induced radical behaviour in human cytochrome c phospholipid complexes: Implications for the enhanced pro-apoptotic activity of the G41S mutant.' The Biochemical journal. Russell, Henry J and Hardman, Samantha J O and Heyes, Derren J and Hough, Michael A and Greetham, Gregory M and Towrie, Michael and Hay, Sam and Scrutton, Nigel S (2013) 'Modulation of ligand–heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond–second temporal range.' FEBS Journal, 280 (23). pp. 6070-6082. Doutch, James and Hough, Michael A and Hasnain, S. Samar and Strange, Richard W (2012) 'Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography.' Journal of Synchrotron Radiation, 19 (1). pp. 19-29. Dwarakanath, Srivatsa and Chaplin, Amanda K and Hough, Michael A and Rigali, Sébastien and Vijgenboom, Erik and Worrall, Jonathan A R (2012) 'Response to Copper Stress in Streptomyces lividans Extends beyond Genes under Direct Control of a Copper-sensitive Operon Repressor Protein (CsoR).' Journal of Biological Chemistry, 287 (21). pp. 17833-17847. Strange, Richard W and Hough, Michael A and Antonyuk, Svetlana V and Hasnain, S. Samar (2012) 'Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase.' PloS One, 7 (9). e44811. Antonyuk, Svetlana V and Hough, Michael A (2011) 'Monitoring and validating active site redox states in protein crystals.' Biochimica et biophysica acta, 1814 (6). pp. 778-784. Hough, Michael A and Antonyuk, Svetlana V and Barbieri, Sonia and Rustage, Neil and McKay, Alison L and Servid, Amy E and Eady, Robert R and Andrew, Colin R and Hasnain, S Samar (2011) 'Distal-to-proximal NO conversion in hemoproteins: the role of the proximal pocket.' Journal of molecular biology, 405 (2). pp. 395-409. N 1089-8638 Leferink, Nicole G H and Han, Cong and Antonyuk, Svetlana V and Heyes, Derren J and Rigby, Stephen E J and Hough, Michael A and Eady, Robert R and Scrutton, Nigel S and Hasnain, S Samar (2011) 'Proton-coupled electron transfer in the catalytic cycle of Alcaligenes xylosoxidans copper-dependent nitrite reductase.' Biochemistry, 50 (19). pp. 4121-4131.