Beard, Louise - University of Essex - School of Biological Sciences

个人简介

Won Excellence in Teaching ETA Award 2016 (Experienced Staff), University of Essex Lecturer, School of Biological Sciences, Univerisity of Essex 2008-present Lecturer, Access course and A-level Biology, Colchester Institute 2004-2008 Clinical Scientist, clinical molecular genetics group, National Hospital for Neurology and Neurosurgery, Queen Square, London 2001-2003 Research Associate, Novartis Pharmaceuticals 2001 PhD in clinical, genetic and expression studies of human channelopathies, Neurogenetics group, Institute of Neurology, NHNN, Queen Square, UCL 2001 BSc (Hons) in Biomedical sciences with molecular biology King's College London 1997

研究领域

Human neurological disorders Parkinson's disease and Alzheimer's disease Muscle and CNS ion channelopathies Epilepsy and episodic ataxia (EA1 and 2) Cancer and cellular pathology

近期论文

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Rajakulendran S, Labrum RW, Graves TD,Tomlinson S, Eunson LH, Davis MB, Schorge S, Kullmann DM, Hanna MG. PAW31 Clinical and genetic spectrum of the episodic ataxias: the UK perspective. Journal of Neurology, Neurosurgery & Psychiatry 81(11) p32. Rajakulendran S, Graves TD, Labrum RW, Kotzadimitriou D, Eunson L, Davis MB, Davies R, Wood NW, Kullmann DM, Hanna MG, Schorge S. Genetic and functional characterisation of the P/Q calcium channel in episodic ataxia with epilepsy. J Physiol. 2010 588:1905-1913. Labrum RW, Rajakulendran S, Graves TD, Eunson LH, Bevan R, Sweeney MG, Hammans SR, Tubridy N, Britton T, Carr LJ, Ostergaard JR, Kennedy CR, Al-Memar A, Kullmann DM, Schorge S, Temple K, Davis MB, Hanna MG. Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing. J Med Genet. 2009; 46: 786-91. Graves TD, Imbrici P, Kors EE, Terwindt GM, Eunson LH, Frants RR, Haan J, Ferrari MD, Goadsby PJ, Hanna MG, van den Maagdenberg AM, Kullmann DM. Premature stop codons in a facilitating EF-hand splice variant of CaV2.1 cause episodic ataxia type 2. Neurobiol Dis. 2008; 32:10-15. Khan NL, Jain S, Lynch JM, Pavese N, Abou-Sleiman P, Holton JL, Healy DG, Gilks WP, Sweeney MG, Ganguly M, Gibbons V, Gandhi S, Vaughan J, Eunson LH, Katzenschlager R, Gayton J, Lennox G, Revesz T, Nicholl D, Bhatia KP, Quinn N, Brooks D, Lees AJ, Davis MB, Piccini P, Singleton AB, Wood NW. Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data. Brain. 2005;128:2786-96. Imbrici P, Eunson LH, Graves TD, Bhatia KP, Wadia NH, Kullmann DM, Hanna MG. Late-onset episodic ataxia type 2 due to an in-frame insertion in CACNA1A. Neurology. 2005;65:944-6. Eunson LH, Graves TD, Hanna MG. New calcium channel mutations predict aberrant RNA splicing in episodic ataxia. Neurology. 2005;65:308-10. Pulkes T, Liolitsa D, Eunson LH, Rose M, Nelson IP, Rahman S, Poulton J, Marchington DR, Landon DN, Debono AG, Morgan-Hughes JA, Hanna MG. New phenotypic diversity associated with the mitochondrial tRNA(SerUCN) gene mutation. Neuromuscul Disord. 2005 ;15:364-71. Khan NL, Horta W, Eunson L, Graham E, Johnson JO, Chang S, Davis M, Singleton A, Wood NW, Lees AJ. Parkin disease in a Brazilian kindred: Manifesting heterozygotes and clinical follow-up over 10 years. Mov Disord. 2005;20:479-84. Georgopoulos NA, Papapetropoulos S, Chroni E, Papadeas ES, Dimopoulos PA, Kyriazopoulout V, Davis MB, Eunson L, Kourounis G, Tzingounist VA. Spinocerebellar ataxia and hypergonadotropic hypogonadism associated with familial sensorineural hearing loss. Gynecol Endocrinol. 2004;19:105-10. Imbrici P, Jaffe SL, Eunson LH, Davies NP, Herd C, Robertson R, Kullmann DM, Hanna MG. Dysfunction of the brain calcium channel CaV2.1 in absence epilepsy and episodic ataxia. Brain. 2004;127:2682-92. Kinali M, Jungbluth H, Eunson LH, Sewry CA, Manzur AY, Mercuri E, Hanna MG, Muntoni F. Expanding the phenotype of potassium channelopathy: severe neuromyotonia and skeletal deformities without prominent Episodic Ataxia. Neuromuscul Disord. 2004;14:689-93. Scherfler C, Khan NL, Pavese N, Eunson L, Graham E, Lees AJ, Quinn NP, Wood NW, Brooks DJ, Piccini PP. Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism. Brain. 2004;127:1332-42. Barclay J, Patel S, Dorn G, Wotherspoon G, Moffatt S, Eunson L, Abdel'al S, Natt F, Hall J, Winter J, Bevan S, Wishart W, Fox A, Ganju P. Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci. 2002 ;22:8139-47. Rea R, Spauschus A, Eunson LH, Hanna MG, Kullmann DM. Variable K(+) channel subunit dysfunction in inherited mutations of KCNA1. J Physiol. 2002 ;538:5-23. Davies NP, Eunson LH, Samuel M, Hanna MG. Sodium channel gene mutations in hypokalemic periodic paralysis: an uncommon cause in the UK. Neurology. 2001;57:1323-5. Jouvenceau A, Eunson LH, Spauschus A, Ramesh V, Zuberi SM, Kullmann DM, Hanna MG. Human epilepsy associated with dysfunction of the brain P/Q-type calcium channel. Lancet. 2001;358:801-7. Jouvenceau A, Eunson L, Spauschus A, Ramesh V, Hanna MG, Kullmann DM. Premature termination in the CACNA1A gene observed in episodic ataxia type 2 (EA2) results in a loss of alpha1A calcium channel function. European Journal of Neuroscience 2000; 12: Supp p454. Spauschus A, Rea R, Eunson L, Hanna MG, Kullmann DM. Mutations of Kv1.1 found in patients with episodic ataxia type 1 (EA1) affect the open probability of channels in vitro. European Journal of Neuroscience 2000; 12: Supp p25. Jouvenceau A, Eunson L, Spauschus A, Ramesh V, Hanna MG, Kullmann DM. Non-functional alpha(1A) calcium channel in episodic ataxia type 2. Journal of Physiology 2000; 525: Supp p75.