Ojo, Opeolu - University of East London - School of Health, Sport and Bioscience

研究领域

My research interest is in drug discovery with special interest in the development of nvel anti-diabetic agents. As a scientist in Nigeria, I worked extensively on the characterization of the anti-diabetic properties of indigenous Nigerian medicinal plants. At University of Ulster, my PhD studies centred on the isolation and characterization of novel amphibian skin peptides for the treatment of type 2 diabetes. As a Postdoctoral Research Scientist, I investigated biological effects of some previously identified amphibian host defence peptides as novel agents for the treatment of obesity-diabetes. Currently, my research focuses on: Discovery, targets, mode of actions and potential therapeutic roles of novel agents from natural sources in correcting metabolic derangements that characterize type 2 diabetes In silico design of hybrid peptides as well as novel analogues of endogenous and exogenous peptides for the treatment of type 2 diabetes Regulation of non-classical beta cell receptors and the role of environmental endocrine disruptors on the development of type 2 diabetes.

近期论文

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Srinivasan DK, Ojo OO, Owolabi BO, Conlon JM, Flatt PR, Abdel-Wahab YHA (2015). [I10W] tigerinin-1R enhances both insulin sensitivity and pancreatic beta cell function and decreases adiposity and plasma triglycerides in high-fat mice.Acta diabetologica, 1-13. DOI:10.1007/s00592-015-0783-3. Olayaki LA, Irekpita JE, Yakubu MT, Ojo OO (2015). Methanolic extract of Moringa oleifera leaves improves glucose tolerance, glycogen synthesis and lipid metabolism in alloxan-induced diabetic rats.Journal of Basic and Clinical Physiology and Pharmacology. DOI:10.1515/jbcpp-2014-0129 Srinivasan D, Ojo OO, Owolabi BO, Conlon JM, Flatt PR, Abdel-Wahab YHA (2015). The frog skin host-defense peptide CPF-SE1 improves glucose tolerance, insulin sensitivity and islet function and decreases plasma lipids in high-fat fed mice.European Journal of Pharmacology,764, 38-47. Sarno G, Daniele G, Tirabassi G, Chavez AO, Ojo OO, Orio F, Kahleova H, Balercia G, Grant WB, De Rosa B, Colao A, Muscogiuri, G. (2015). The impact of vitamin D deficiency on patients undergoing kidney transplantation: focus on cardiovascular, metabolic, and endocrine outcomes.Endocrine, 1-7. Ojo OO and Jide-Ojo C. C. (2015). Insulinotropic actions of acetone extracts of Moringa oleifera involve the induction of membrane depolarization and enhancement of intracellular calcium concentration in BRIN-BD11 clonal pancreatic cells. Journal of Experimental and Integrative Medicine 5(1): 36 – 41 (DOI: 10.5455/jeim.080115.or.117) Olayaki LA, Soladoye AO and Ojo OO (2015). Melatonin improves diabetes-induced foetal growth retardation in rats. Bangladesh Pharmaceutical Journal 18(1): 42-47 Ojo OO, Srinivasan DS, Owolabi BO, Flatt PR and Abdel-Wahab YHA (2015).Beneficial effects of tigerinin-1R on glucose homeostasis and beta cell function in mice with diet-induced obesity-diabetes. Biochimie 109: 18-26 Ojo OO, Srinivasan DS, Owolabi BO, Flatt PR and Abdel-Wahab YHA (2015). Magainin-AM2 improves glucose homeostasis, and beta cell function in high fat fed mice. BBA General Subjects, 1850:80-87. Hannan JMA, Ojo OO, Ali L, Rokeya B, Khaleque J, Akhter M, Flatt PR, Abdel-Wahab YHA (2015). Actions underlying antidiabetic effects of Ocimum sanctum leaf extracts in animal models of type 1 and type 2 diabetes. European Journal of Medicinal Plants, 5(1):1-12 Ojo OO, Srinivasan DS, Owolabi BO, Flatt PR and Abdel-Wahab YHA (2015). Magainin-related peptides stimulate insulin-release and improve glucose tolerance in high fat fed mice. Journal of Protein and Peptide Letters 22(3):256-263. Thomson HAJ, Ojo OO, Flatt PR, Abdel-Wahab YHA (2014). Antidiabetic actions of aqueous bark extract of Swertia chirayita on insulin secretion, cellular glucose uptake and protein glycation. Journal of Experimental and Integrative Medicine 4:1-5 Ojo OO (2014). In vitro insulinotropic actions of various extracts of Moringa oleifera leaves. Nigerian Journal of Biotechnology, 27:14-20 Thomson HAJ, Ojo OO, Flatt PR and Abdel-Wahab YHA (2014). Aqueous bark extracts of Terminalia arjuna stimulates insulin release, enhances insulin action and inhibits starch digestion and protein glycation in vitro. Austin Journal of Endocrinology and Diabetes, 1:1-6. Fatumo SA, Adoga MP, Ojo OO, Oluwagbemi O, Adeoye TA, Ewejobi I, Adebiyi M, Adebiyi E, Clement B, Oyekanmi, N (2014). Computational Biology and Bioinformatics in Nigeria. PLOS Computational Biology, 10 (4):E1003516 (1-7). Srinivasan D, Ojo OO, Abdel-Wahab YH, Flatt PR, Guilhaudis L, Conlon JM. (2014). Insulin-releasing and cytotoxic properties of the frog skin peptide, tigerinin-1R: A structure-activity study. Peptides14: 43-46. Ojo OO, Abdel-Wahab YHA, Flatt PR and Conlon JM. (2013). Insulinotropic actions of the frog skin host-defense peptide alyteserin-2a: a structure-activity study. Chemical Biology & Drug Design, 82 (2): 196-204 Ojo OO, Conlon JM, Flatt PR & Abdel-Wahab YHA. (2013). Frog skin peptides (tigerinin-1R, magainin-AM1, AM2, CPF-AM1 and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTa cells. Biochemistry Biophysics Research Communications,431(1): 14-18 Jide-Ojo CC, Gungula DT and Ojo OO (2013). Extracts of Jatropha curcas L. exhibit significant insecticidal and grain protectant effects against maize weevil, Sitophilus Zeamais (Coleoptera: Curculionidae). Journal of Stored Products and Postharvest Research, 4(3): 44 -50. Ojo OO, Abdel-Wahab YHA, Flatt PR, Mechkarska M and Conlon JM (2011). Tigerinin-1R: a potent, non-toxic insulin-releasing peptide isolated from the skin of the Asian frog, Hoplobatrachus rugulosus. Diabetes, Obesity and Metabolism,13(12):1114-1122 Zahid OK, Mechkarska M, Ojo OO, Abdel-Wahab YHA, Flatt PR, Meetani MA, and Conlon JM (2011). Caerulein- and xenopsin-related peptides with insulin-releasing activities from skin secretions of the clawed frogs, Xenopus borealis and Xenopus amieti (Pipidae). General and comparative endocrinology. 172(2): 314-320 Jide-Ojo CC and Ojo OO (2011). Evaluation of the biological effects of leaf extracts of Jatropha curcas against Sitophilus zeamais (Coleoptera: Curculionidae). Electronic journal of environmental, agricultural and food chemistry. 10(5): 2166 – 2172 Mechkarska M, Ojo OO, Meetani MA, Coquet L, Jouenne T, Abdel-Wahab YHA, Flatt PR, King JD and Conlon JM