Casalotti, Stefano - University of East London - School of Health, Sport and Bioscience

研究领域

My main current research interest is understanding the molecular mechanism that support behavioural changes following use or misuse of psychoactive substances. We use the fruit fly Drosophila to address questions about the changes in gene expression that occur following exposure to alcohol and how some of these changes and behavioural changes can be regulated through pharmacological intervention. My interests in cellular and molecular mechanism is reflected in my teaching in modules of Biochemistry and Cellular and Molecular Biology. I also have a broader interest in how teaching practices need to evolve making use of current technologies and methodologies to create effective learning environments. I strongly believe that Universities are 'learning' institutions and not 'teaching' institution where learning is a joint action between students and academics.

近期论文

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beta3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear.I Brunetta , SO Casalotti , IR Hart, A Forge, LE Reynolds.. 2012. BMC Cell Biol. Mar 17;13(1):5.. NJongkamonwiwat , P Phansuwan-Pujito , SO Casalotti, A Forge, H Dodson, P Govitrapong . (2006)The existence of opioid receptors in the cochlea of guinea pigs. Eur J Neurosci. 23:2701-11. P E.M. Martin, S. L..Coleman, S. O. Casalotti, A. Forge and W.H. Evans (1999) Properties of connexin26 gap junctional proteins derived from mutations associated with non-syndromal heriditary deafness Human Molecular genetics. 8:2369-2376 B. Chetsawang, S.O. Casalotti,, P. Phansuwan-Pujito, N. Kotchabhakdi, P. Govitrapong (1999) Gene expressions of opioid receptors and G-proteins in pineal glands. Biochem Biophys Res Commun 262:775-80 G.S.G. Geleoc, S.O. Casalotti, A. Forge and J.F. Ashmore (1999) A sugar transporter as a candidate for the outer hair cell motor. Nature Neuroscience 2, 713-719. E. Kumarnsit, P. Harnyuttanakorn, D. Meksuriyen, P. Govitrapong, B.A. Baldwin, N. Kotchabhakdi and S.O. Casalotti (1999) Pseudoephedrine, a Sympathomimetic Agent, Induces Fos-like Immunoreactivity in Rat Nucleus Accumbens and Striatum. Neuropharmacology, 38, 1381-1387 A. Forge, D. Becker, S. O. Casalotti, J. Edwards, W.H. Evans, N. Lenh and M. Souter (1999) Gap junctions and connexin expression in the inner ear. In Novartis Foundation Symposium 219: “Gap Junction-Mediated Intercellular Signalling in Health and Disease” J. Wiley & Sons Ltd pp 134-156. P. Sirirpurkpong, P. Harnyuttanakorn, C. Chindadoungratana, N. Kotchabhakdi, P. Wichyanuwat and S.O. Casalotti. (1997) Dexamethasone, but not stress, alters mitochondrial benzodiazepine receptor gene expression in rat. European Journal of Pharmacology 331, 227-235. J.Wattanathorn, N. Kotchabhakdi, S.O. Casalotti, B.A. Baldwin and P. Govitrapong. (1996) Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase. European Journal of Pharmacology 313, 69-72S. O. Casalotti, A.P. Kozikowski, A Fauq, W. Tückmantel and K.E. Krueger (1993) Monoclonal antibodies against a phencyclidine derivative are used to investigate protein-ligand interaction. European Journal of Pharmacology. (Molecular Pharmacology Section.)247, 209-213. S.O. Casalotti, G. Pelaia, A. G. Yakolev, T. Csikós, D. R. Grayson, K.E. Krueger. (1992) Structure of the rat gene encoding the mitochondrial benzodiazepine receptor Gene, 121, 377-382. S. O. Casalotti, A.P. Kozikowski, A Fauq, W. Tückmantel and K.E. Krueger. (1992) Design of an irreversible affinity ligand for the phencyclidine recognition site on N-methyl-D-aspartate-type glutamate receptors. Journal of Pharmaceutical and Experimental Theurapetics, 260, 21-28. A.P. Kozikowski, A.H. Fauq, W.Tuckmantel, S.O. Casalotti and K.E.Krueger . (1991) Synthesis of TCP-based irreversible alkylators of the PCP recognition site. Synletters. 9, 654-655 W Tongjaroenbungam, N Jongkamonwiwat, J Cunningham, P Phansuwan-Pujito, HC Dodson, A Forge, P Govitrapong, SO Casalotti. (2004), Opioid modulation of GABA release in the rat inferior colliculus BMC Neuroscience 5:31 F.A.Stephenson, M.J. Duggan and S.O. Casalotti. (1989) Identification of the Alpha-3 Subunit in the GABAA Receptor Purified from Bovine Brain.Febs Letters., 2443 358-62. S.O. Casalotti, F.A. Stephenson and E.A. Barnard.(1986) Separate Subunits for Agonist and Benzodiazepine Binding in the  Aminobutyric Acid-A Receptor Oligomer.Journal of Biological Chemistry. 261, 15013-15016. F.A Stephenson, S.O. Casalotti, C. Mamalaki and E.A. Barnard. (1986) Antibodies Recognising the GABAA/Benz. A Forge, Marziano NK, Casalotti SO, Becker DL, Jagger D. (2003) The inner ear contains heteromeric channels composed of cx26 and cx30 and deafness-related mutations in cx26 have a dominant negative effect on cx30. Cell Commun Adhes. 10:341-6. A Forge, Becker D, Casalotti S, Edwards J, Marziano N, Nevill (2003) G. Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals. J Comp Neurol. 467:207-31. P. Phansuwan-Pujito, L. Saleema , S. Mukda, N. Jutapakdeegul, S.O. Casalotti, A. Forge, H. Dodson, P. Govitrapong (2003) The opioid receptors in inner ear of different stages of postnatal rats. Hear Res. 184:1-10. N. Jutapakdeegul, SO Casalotti, P Govitrapong, N Kotchabhakdi. (2003) Postnatal touch stimulation acutely alters corticosterone levels and glucocorticoid receptor gene expression in the neonatal rat. Dev Neurosci.;25(1):26-33.