Reddy, Tummala Rama Krishna - University of East London - School of Health, Sport and Bioscience

个人简介

Reddy is a senior lecturer in Medicinal chemistry and a member of Medicines Research Group. He has previously worked as a lecturer in Medicinal chemistry at the Department of Pharmacy, University of Hertfordshire (2012 to 2015) and as a postdoctoral research fellow in Medicinal chemistry and Drug design at the University of Nottingham for 5 years. Reddy obtained his PhD in Medicinal chemistry at the University of Sheffield, M.Phil (research) in Computational drug design at the University of Nottingham and M.Pharm in Pharmaceutical chemistry at the IIT, Banaras Hindu University (India).

研究领域

Design and development of potential drug candidates for the treatment of Chagas disease. Kinetic solubility assays for the drug like molecules Reddy has expertise of working on drug discovery projects involving rational drug design, synthesis and lead optimization of small molecules. His current research interests are in Medicinal chemistry aspects of Neglected tropical diseases and Staphylococcus aureus infections. He is currently supervising a PhD student. Reddy uses various drug design strategies to understand how the structures of active derivatives of lead compounds/hit compounds interact with targeted receptors and guide the synthesis. Various drug design strategies that are used in his lab for the compound design are Structure based drug design, Pharmacophore based drug design, Lead hopping, In-silico DMPK studies.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Design, Synthesis and SAR Exploration of Trisubstituted 1,2,4-Triazoles as Potential Inhibitors of the Annexin A2-S100A10 Protein Interaction.Reddy, T., Li, C., Guo, X., Fischer, P., Dekker, L.. 2014. Bioorganic & Medicinal Chemistry. 5378-5391. Three-DimensionalPharmacophore Design and Biological Screening Identifies Substituted1,2,4-Triazole Compounds as Inhibitors of the Annexin A2-S100A10 ProteinInteraction.Reddy, T., Li, C., Fischer, P., Dekker, L.. 2012. ChemMedChem. 1435-1446. Design, Synthesis, and SAR Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one Analogues as Inhibitors of the Annexin A2–S100A10 Protein Interaction.Reddy, T., Li, C., Guo, X., Myrvang, H., Fischer, P., Dekker, L.. 2011. Journal of Medicinal chemistry. 2080-2094. Patent: Preparation of pyrrole derivatives as S100 protein binding interaction inhibitors for treatment of cancer and other diseases.Reddy, T., Li, C., Fischer, P., Dekker, L.. 2011. Patent application has been filed by the Cancer Research Technology Limited (UK), Patent No. WO2011092505. Cy5-labeled S100A10 tracer used to identify inhibitors of the protein interaction with annexin A2. Li, C., Reddy, T., Fischer, P., Dekker, L.. 2010. Assay and Drug Development Technology. 85-95. Structure-based design, synthesis, and SAR exploration of pyrrole-2-one analogues as inhibitors of the annexin A2-S100A10 protein interaction: potential anti-angiogenesis therapeutics.Reddy, T., Li, C., Guo, X., Fischer, P., Dekker, L.. 2010. Journal of Pharmacy and Pharmacology. 1373-1374. Synthesis and Evaluation of a Focused Library of PyridineDicarbonitriles Against Prion Disease.Guo, K., Mutter, R., Heal, W., Reddy, T., Cope, H., Pratt, S., Thompson, M., Chen, B.. 2008. European Journal of Medicinal Chemistry. 93-106. Mechanistic studies leading to a new procedure for rapid microwave assisted generation of pyridine-3,5-dicarbonitrile libraries.Guo, X., Thompson, M.J., Reddy, TRK., Mutter, R., Chen, B.. 2007. Tetrahedron. 63 (24) 5300-5311. Library Design, Synthesis and Screening: Pyridine Dicarbonitriles as Potential Prion Disease Therapeutics.Reddy, TRK., Mutter, R., Heal, W., Guo, K., Gillet, V.J., Pratt, S., Chen, B.. 2006. Journal of Medicinal Chemistry. 49(2), 607-615.