MORGAN, Winston - University of East London - School of Health, Sport and Bioscience

个人简介

Winston Morgan is currently a Reader in Toxicology and Clinical Biochemistry at University of East London. His university education began with a BSc at NELP (now University of East London) in Applied Biology specialising in Pharmacology. He then worked in biomedical research for several years before completing my PhD in Biochemical Toxicology at the London School of Pharmacy (now UCL School of Pharmacy) in 1993. Winston returned to UEL in 1993 as a postdoctoral fellow and became a lecturer in 1998. Over the years he has contributed to the teaching of all the programmes in the Bioscience subject area particularly Biomedical Sciences, Forensic Sciences, Toxicology in the Pharmacology. For the 10 years he was programme leader for up to 11 MSc programmes in the Bioscience subject area.

研究领域

Winston Morgan’s research interests are many and varied, he has been a member of the British Toxicology Society and Biochemical Society for over 20 years as well as a Fellow of the institute of biology. He has published over 40 peer review publications. His early research was in signal transduction in blood cells and the protein chemistry of auto-antibodies, he then moved on to liver and kidney toxicity. He is currently supervising his 13th PhD student. Past students have been in areas as diverse as human placenta as an alternative to animals in toxicity testing, the role of probiotics and prebiotics in gut health and wound healing properties of certain Nigerian plants. He has an ongoing interest in the toxicity of Amphetamine related compounds. Dr Morgan is currently working on a project to understand the long term toxicity of highly active antiretroviral therapy (HAART) in aids patients. He is currently supervising PhD students are working to provide a better understanding of how Paracetamol and NSAID works in terms of anti-pyresis and anti-inflammation. His research has been informed by a knowledge of mechanistic toxicology, toxicity testing, pharmacology and clinical biochemistry. Away from laboratory-based research Dr Morgan is involved in several Learning & Teaching projects looking at how to improve the student experience and performance of widening participation students particularly, BAME studnets, this work has led to several national keynote presentations.

近期论文

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George Antepim Pesewu, Ronald R. Culter, David P. Humber, Winston A. Morgan Evaluation of Antibacterial Activity and Phytoconstituents of the Aqueous Leaves Extract of Alchornea Cordifolia International Scientific Research Journal, 2015, 1(07), pp. 48-54. DOI: 10.18483/IRJSci.54 Adebola, O.O.; Corcoran, O.; Morgan, W.A. 2014. Synbiotics: the impact of potential prebiotics inulin, lactulose and lactobionic acid on the survival and growth of lactobacilli probiotics. Journal of Functional Foods, 10, 75-84. Article: : Protective effects of prebiotics inulin and lactulose from cytotoxicity and genotoxicity in human colon adenocarcinoma cells Oluwakemi Adebola • Olivia Corcoran • Winston A. Morgan [Show abstract] Full-text • Article • Jun 2013 • Food Research International Adewale Adetut • Winston A. Morgan • Olivia Corcoran 2012, F. Chimezie, Antibacterial activity and in vitro cytotoxicity of extracts and fractions of Parkia biglobosa (Jacq.) Benth. stem bark and Ageratum conyzoides Linn. Leaves, Environmental Toxicology and Pharmacology 34 (2012) 478–483. Abubakar Abdulhamid and Winston A. Morgan European Journal of Experimental Biology, 2012, 2 (5):1444-1450. Evaluation of hydroquinone target organ toxicity against liver (BRL3A) and dermal (A375p) cell lines. Article: Ethnopharmacological survey and in vitro evaluation of wound-healing plants used in South-western Nigeria Adewale Adetutu • Winston A Morgan • Olivia Corcoran [Show abstract] No preview • Article • Apr 2011 • Journal of Ethnopharmacology Article: The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells Jiayu Gao • Winston A Morgan • Alberto Sanchez-Medina • Olivia Corcoran Article: Antibacterial, antioxidant and fibroblast growth stimulation activity of crude extracts of Bridelia ferruginea leaf, a wound-healing plant of Nigeria Adewale Adetutu • Winston A Morgan • Olivia Corcoran [Show abstract] No preview • Article • Jan 2011 • Journal of Ethnopharmacology Article: The use of High Performance Thin-Layer Chromatography to determine the role of membrane lipid composition in bile salt-induced kidney cell damage Winston A Morgan • Thanh Nk • Yinuo Ding [Show abstract] No preview • Article • Feb 2008 • Journal of pharmacological and toxicological methods Author(s): Kohan, Ghotbi K.; Morgan, W. A. Stress proteins as a suitable biomarker of environmental pollution: International Journal of Environmental Research Volume: 1 Issue: 4 Pages: 290-295 , 2007. Winston A. Morgan, Thanh NK and Yinuo Ding. Membrane lipid composition may play a key role in the toxicity of bile salts to kidney cells. Comparative Biochemistry and Physiology May 2005. Article: Are Bile Acids Involved in the Renal Dysfunction of Obstructive Jaundice? An Experimental Study in Bile Duct Ligated Rats Balwant Kaler • Tony Karram • Winston A Morgan • Peter H Bach • Ibrahaim M Yousef • Arieh Bomzon [Show abstract] No preview • Article • Oct 2004 • Renal Failure Conference Paper: The role of dopamine metabolism in the cytotoxicity of MDMA (3,4-methylenedioxymethamphetamine) and related compounds Y Adeeko • WA Morgan No preview • Conference Paper • Sep 2004 Conference Paper: Does the uncoupling of mitochondrial oxidative phosphorylation by MDMA (3,4-methylenedioxymethamphetamine) and related compounds contribute to hyperthermia? J Afari • WA Morgan No preview • Conference Paper • Sep 2004 Deborah A. Early, Gillian Sturman S.R. Sooranna and Winston A.. Morgan. Precision-Cut Human Placenta slices as a model for In Vitro Toxicity Testing. Hum. & Exp. Toxicol. 18, 761 1999. Article: The role of ursodeoxycholic acid in bile acid-mediated kidney fragment toxicity Winston A. Morgan • Balwant Kaler • Peter H. Bach [Show abstract] No preview • Article • Jan 1999 • Experimental and Toxicologic Pathology Article: Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil Gurpreet S Ratra • Winston A Morgan • Jenny Mullervy • Christopher J Powell • Matthew C Wright [Show abstract]Full-text • Article • Oct 1998 • Toxicology Article: The relationship between sodium chloride concentration and bile acid cytotoxicity in cultured kidney cells W A Morgan • Y Dingg • P H Bach [Show abstract] No preview • Article • Jun 1998 • Renal Failure Article: The role of reactive oxygen species in adriamycin and menadione-induced glomerular toxicity Winston A Morgan • Balwant Kaler • Peter H Bach [Show abstract] No preview • Article • Mar 1998 • Toxicology Letters