Corcoran, Olivia - University of East London - School of Health, Sport and Bioscience

个人简介

Professor Olivia Corcoran is a Fellow of the Higher Education Academy, Chartered Biologist and currently Professor of Bioanalytical Chemistry in the School of Health, Sport and Bioscience at the University of East London. She leads the Medicines Research Group focusing on quality, safety and efficacy of pharmaceutical and phytomedicines. Born and educated in Ireland, her career includes three years working on drug discovery at Pfizer Central Research, Sandwich and three years on adverse drug reactions at Imperial College Medical School, London. Her PhD, funded by Glaxo Group Research, developed novel NMR technologies for investigating drug metabolism. In 2000, she joined Bruker BioSpin in California as Product Manager of NMR flow technologies and was lead applications scientist for the CryoFlowProbe, winning an R&D100 Award in 2003. Later that year she was awarded a prestigious C. W. Maplethorpe Research Fellowship to investigate adverse drug reactions of NSAIDs at the Department of Pharmacy, King's College London. Dr Corcoran's published expertise is in developing novel flow technologies to further drug discovery. Current collaborations include the Department of Pharmacy, King's College London, The School of Chemical and Biological Sciences, Queen Mary, University of London, The University of Cape Town and Imperial College London. Awarded MSc (Distinction) in Science entrepreneurship from Sir John Cass Business School in 2005.

研究领域

Biomedical chemistry, identification of drug metabolites from biofluids in metabolism and toxicology studies, clinical diagnostics and metabolic profiling. Characterisation of bioactive drugs from ethnobotanical and microbial sources using chromatography and NMR spectroscopy. Development of analytical tools for reducing and refining the use of animals in pharmaceutical research. Applications of multiple-hyphenated NMR spectroscopy including high performance liquid chromatography coupled to NMR and mass spectrometry: LC-NMR-MS, capLC-NMR, LC-MS-SPE-NMR, and LC-cryoflow NMR spectroscopy.

近期论文

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R Hernandez-Bello, RV Garcia-Rodriguez, K Garcia-Sosa, LM Pena-Rodriguez, M Vazquez-Hernandez, FR Ramos-Morales, O Corcoran and A Sanchez-Medina. Salvinorin A content in legal high products of Salvia divinorum sold in Mexico. Forensic Science International. 2015. 249:197-201. A Adetutu, WA Morgan and O. Corcoran. Antibacterial, antioxidant and fibroblast growth stimulation activity for crude extracts of Bridelia ferruginea, a wound-healing plant of Nigeria. Journal of Ethnopharmacology, 2011, 133: 116-119. S. Cobb, R Heaney, O Corcoran and SK Henderson-Begg. Using mobile phones to increase classroom interaction. AACE Journal of Educational Multimedia and Hypermedia, 2010 , 19(2): 147-157. J Gao, H Zhao. PJ Hylands and O. Corcoran. Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells. Journal of Pharmaceutical and Biomedical Analysis, 2010, 53:723-728. S. Cobb, R Heaney, O Corcoran and S Henderson-Begg. The learning gains and student perceptions of a second life virtual lab. Bioscience Education, 2009, 13, http://www.bioscience.heacademy.ac.uk/journal/vol13/beej-13-5.pdf A Sanchez-Medina, PC Stevenson, S Habtemariam, LM Pena-Rodriguez, O Corcoran, TA Mallet and NC Veitch. Triterpenoid saponins from the cytotoxic root extract of Sideroxylon foetidissimum, subsp. gaumeri. Phytochemistry, 2009, 70:765-772. A Sanchez-Medina, PC Stevenson, S Habtemariam, LM Pena-Rodriguez, O Corcoran, TA Mallet and NC Veitch. Triterpenoid saponins from the cytotoxic root extract of Sideroxylon foetidissimum, an endemic Yucatecan medicinal plant. Planta Medica, 2008, 74(9):908-909. J Gao, A Sanchez-Medina, BA Pendry, MJ Hughes, GP Webb and O Corcoran. Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures. Journal of Pharmacy and Pharmaceutical Sciences, 2008, 11 (1): 77-87. A Sanchez-Medina, CJ Etheridge, GE Hawkes, PJ Hylands, BA Pendry, MJ Hughes and O Corcoran. Comparison of rosmarinic acid content in commerical tinctures produced from fresh and dried lemonbalm (Melissa officinalis). Journal of Pharmacy and Pharmaceutical Sciences, 2007, vol 10, no 4, 455-463. LD Viet, PJ Houghton, B Forbes, O Corcoran and PJ Hylands. Wound healing activity of Alocasia odora (Roxb.) Koch. Planta Medica, 2006, 72 (11): 991-991 JL Griffin and O Corcoran. High resolution magic angle spinning 13C NMR spectroscopy of cerebral tissue. Magnetic Resonance Materials in Physics, Biology and Medicine, 2005, 18, 51-56. O Corcoran. Chapter 8, NMR spectroscopy as a versatile analytical platform for toxicology research. In Handbook of Toxicogenomics: A Strategic view of current research and applications, p161-181,published February 2005, Ed. J. Borlak, Wiley-VCH, Germany. ISBN-10: 3-527-30342-1. O Corcoran. Hit discovery from natural products in pharmaceutical R&D. eMagRes. 2015. 4:1-8. DOI 10.1002/9780470034590.emrstm1432 L Dawkins & O Corcoran. Acute electronic cigarette use: nicotine delivery and subjective effects in regular users. Psychopharmacology. 2014. 231 (2), 401-407. LD Viet, PJ Hylands, PJ Houghton, B Forbes and O. Corcoran. Investigating the wound-healing activity of Alocasia odora (Roxb.) Koch. Journal of Pharmacy and Pharmacology, 2005, 57, S73-74. O. Corcoran and M. Spraul. LC-NMR-MS in drug discovery. Drug Discovery Today, 2003, vol. 8, no. 14, 624-631. M. Spraul, A. S. Freund, R. E. Nast, R. S. Withers, W. E. Maas and O. Corcoran. Advancing NMR sensitivity for LC-NMR-MS using a cryoflow probe: Application to the analysis of acetaminophen metabolites in urine. Analytical Chemistry, 2003, vol. 75, no. 6, 1536-1541. O. Corcoran, P. S. Wilkinson, M. Godejohann, U. Braumann, M. Hofmann and M. Spraul. Advancing sensitivity for flow NMR spectroscopy: LC-SPE-NMR and capillary-scale LC-NMR. American Laboratory, May 2002, 34, 18-21. O. Corcoran, J. C. Lindon, R. Hall, I. M. Ismail and J. K. Nicholson. The potential of 19F NMR spectroscopy for rapid screening of cell cultures for models of mammalian drug metabolism. Analyst, 2001, vol. 126, no. 12, 2103-2016. O. Corcoran, R. W. Mortensen, S. H. Hansen, J. Troke and J. K. Nicholson. HPLC/1H NMR spectroscopic studies of the reactive alpha-1-O-acyl isomer formed during acyl migration of S-naproxen beta-1-O-acyl glucuronide. Chemical Research in Toxicology, 2001, vol. 14, no. 10, 1363-1370. R. W. Mortensen, O. Corcoran, C. Cornett, U. G. Sidelmann, J. C. Lindon, J. K. Nicholson and S. H. Hansen. S-naproxen-alpha-1-O-acyl glucuronide degradation kinetic studies by stopped-flow high-performance liquid chromatography-1H NMR and high-performance liquid chromatography-UV. Drug Metabolism and Disposition, 2001, vol. 29, no. 4, 375-380. C. A. Daykin, O. Corcoran, S. H. Hansen, I. Bjornsdottir, C. Cornett, S. C. Connor, J. C. Lindon and J. K. Nicholson. Application of directly coupled HPLC-NMR to separation and characterization of lipoproteins from human serum. Analytical Chemistry, 2001, vol. 73, no. 6, 1084-1090. Toxicology and Applied Pharmacology, 2011, 254: 221-228.