Rowley, David - University of East London - School of Health, Sport and Bioscience

研究领域

My main areas of interest are related to furthering our understanding of the nature of host-parasite interactions in infectious disease and how we can use this information to develop new strategies for disease control. I do also have a strong interest in pedagogic issues in particular in promoting and evaluating diverse approaches to the delivery and assessment of modules and their impact on student engagement.

近期论文

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Knight, R.C., Rowley, D.A., Skolimowski, I.M. and Edwards, D.I. (1979) ‘ Mechanism of action of nitroimidazole antimicrobial and antitumour radiosensitizing drugs. Effects of misonidazole on DNA.’ Int. J. Radiat. Biol.36, 367-77. Gutteridge, J.M.C., Rowley, D.A., Halliwell, B. and Westermarck,T. (1982) ‘Increased non-protein-bound iron and decreased protection against superoxide radical damage in cerebrospinal fluid from patients with neuronal ceroid lipofuscinosis.’ Lancet ii, 459-60. Rowley, D.A. and Halliwell, B. (1983) ‘Formation of hydroxyl radicals from hydrogen peroxide and iron salts by superoxide- and ascorbate-dependent mechanisms: relevance to the pathology of rheumatoid disease.’ Clinical Sci. 64, 649-653. Rowley, D.A. and Halliwell, B. (1983) ‘ Superoxide-dependent anmd ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: A physiologically significant reaction?’ Arch. Biochem. Biophys. 225, 279-84. Rowley, D.A. and Halliwell, B. (1983) ‘DNA damage by superoxide generating systems in relation to the mechanism of action of the anti-tumour antibiotic Adriamycin.’ Biochem. Biophys. Acta 761, 86-93. Flitter, W., Rowley, D.A. and Halliwell, B. (1983) ‘ Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. What is the physiological iron chelator?’ FEBS Lett. 158, 310-12. Rowley, D.A., Gutteridge, J.M.C., Blake, D., Farr, M. and Halliwell, B. (1984) ‘Lipid peroxidation in rheumatoid arthritis:thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients.’ Clinical Sci. 66, 691-95. Gutteridge, J.M.C., Rowley, D.A., Halliwell, B., Cooper,D.F. and Heeley, D.M. (1984) ‘Copper and iron complexes catalytic for oxygen radical reactions in the sweat from human athletes.’ Clin. Chim. Acta 145, 267-73. Rowley, D.A. and Halliwell, B. (1985) ‘ Formation of hydroxyl radicals from NADH and NADPH in the presence of copper salts.’J. Inorg. Biochem. 23, 103-08. Gutteridge, J.M.C., Rowley, D.A. and Halliwell, B. (1985) Life Chem. Reports 3, 232-43. Gutteridge, J.M.C., Rowley, D.A., Griffiths,E and Halliwell, B. (1985) Low molecular weight iron complexes and oxygen radical reactions in idiopathic haemochromatosis.’ Clinical Sci. 68, 463-467. Rowley, D.A., Knight, R.C., Skolimowski, I.M. and Edwards, D.I. (1979) ‘The effect of nitroheterocyclic drugs on DNA: An in vitro model of cytotoxicity.’ Biochem. Pharmacol. 28, 3009-13. Blake, D.R., Winyard, P., Lunec, J., Williams, A., Good, P.A., Crews, S.J., Gutteridge, J.M.C., Rowley, D.A., Halliwell, B., Cornish, H. and Hider, R.C. (1985) ‘Cerebral and ocular toxicity induced by desferrioxamine.’ Quart. J. Med. 56, 345-55. Contributions to Symposia Proceedings and Chapters in Books Edwards, D.I., Rowley, D.A., Knox, R.J., Skolimowski, I.M. and Knight, R.C.(1980) ‘Nature of DNA damage induced by electrolytically reduced nitroimidazole drugs.’ In Current Chemotherapy and Infectious Disease. Proc. 11th Int. Cong. Chemother., Boston. Publ. Am. Soc. Microbiol. Washington U.S.A. Edwards, D.I., Knox, R.J., Rowley, D.A., Skolimowski, I.M. and Knight , R.C. (1980) ‘ The biochemistry of nitroimidazole drug action.’ In The Biochemistry of Parasites and the Host-Parasite Relationship. Ed. H Van Den Bosche. Publ. Elsevier/North Holland, Amsterdam. Edwards, D.I., Knox, R.J., Rowley, D.A., Skolimowski, I.M. and Knight, R.C. (1980) ‘ Mechanism of cytotoxicity of nitroimidazoles.’ In Chemistry, Pharmacology and Clinical Application of Nitroimidazoles. Proc. Int. Conf. on Nitroimidazoles, Cesenatico, Italy. Rowley, D.A. and Edwards, D.I. (1981) ‘ Possible mechanisms of resistance of anaerobes to nitroimidazoles.’ In Current Chemotherapy and Immunotherapy. Proc. 12th Int. Cong. Chemother., Florence. Publ. Am. Soc. Microbiol. Washington U.S.A. Rowley, D.A., Gutteridge, J.M.C., Blake D. and Halliwell, B (1983) ‘Free radical damage in rheumatoid synovial fluid. Correlations between lipid peroxidation, catalytic iron and clinical indices of disease.’ Proceedings of the Heberden Society Halliwell, B. Rowley, D.A. and Gutteridge, J.M.C. (1984) ’Transition metal catalysts and oxygen radical reactions.’ In Life Science Reports, Proc EMBO Workshop on Oxidative damage and related enzymes. Rome Oct. 1983. Gutteridge, J.M.C., Rowley, D.A. and Halliwell, B.(1984) ‘ Catalytic iron complexes in biological material: A potential for oxygen radical damage.’ In Life Science Reports, Proc EMBO Workshop on Oxidative damage and related enzymes. Rome Oct. 1983. Rwankote, R. and Rowley, D.A. (1998) ‘ The impact of anti-retroviral therapies on HIV-infected black Africans living in London.’ In Proc. 12th World AIDS Conference, Geneva, Switzerland. Rowley, D.A., Knight, R.C., Skolimowski, I.M. and Edwards, D.I. (1980) ‘The relationship between misonidazole cytotoxicity and base composition of DNA.’ Biochem. Pharmacol. 29, 2095-98. Studies on the cytotoxic action of nitroimidazoles. - Ph.D. thesis CNAA (N.E. London Poly, now U.E.L.) Feb 1982 Skolimowski, I.M., Rowley, D.A., Knight, R.C. and Edwards, D.I. (1980) ‘Reduced chloramphenicol-induced damage to DNA.’ J. Antimicro. Chemother.7, 593-97. Gutteridge, J.M.C., Rowley, D.A. and Halliwell, B. (1981) ‘Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts.’ Biochem. J. 199, 263-65. Rowley, D.A. and Halliwell, B. (1982) ‘Superoxide-dependent formation of hydroxyl radicals in the presence of thiol compounds.’ FEBS Lett. 138, 33-36. Hoe, S., Rowley, D.A. and Halliwell, B. (1982) ‘Reactions of ferrioxamine and desferrioxamine with the hydroxyl radical.’ Chemico- Biol. Interact. 41, 75-81. Rowley, D.A. and Halliwell, B. (1982) ‘Superoxide-dependent formation of hydroxyl radicals from NADH and NADPH in the presence of iron salts.’ FEBS Lett. 142, 39-41. Gutteridge, J.M.C., Rowley, D.A. and Halliwell, B.(1982) ‘Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts.’ Biochem.J. 206, 605-09.