Waller, Zoe - University of East Anglia

个人简介

Biography Zoё graduated with a MChem (Distinction) in Chemistry with Pharmaceutical and Forensic Science from the University of Bradford in 2005. She then moved to the Department of Chemistry at the University of Cambridge to continue her studies towards a PhD in Chemical Biology under the supervision of Shankar Balasubramanian. Her thesis was based on the design, properties and function of small molecule ligands which interact with G-quadruplex DNA. Whilst completing her PhD she was heavily involved with teaching and demonstrating undergraduate students and also STIMULUS, where she helped run after-school Science classes. In 2008 she was awarded the Corporate Associates Prize for Practical Class Demonstration in recognition of "outstanding qualities in the teaching of practical chemistry". After completing her PhD in 2009 she gained further teaching experience within the secondary education sector before taking up a position as Senior Demonstrator in Medicinal Chemistry in the School of Pharmacy at UEA. After gaining some further experience in industry at HFL Sport Science she returned to the School in late 2010 as a Lecturer in Chemical Biology. She is currently on the committee of the Royal Society of Chemistry Chemical Biology and Bio-organic interest group, an associate of the Faculty of 1000 and a STEM ambassador.

研究领域

Zoё’s research is focussed at the interface between chemistry and biology and she is particularly interested in drug-nucleic acid interactions and studying alternative DNA structures. She uses many different experimental approaches including organic synthesis, biophysics and molecular biology. Her research has two general themes: switching DNA conformation for uses in nanotechnology and targeting DNA/RNA with small molecule ligands for applications in biology. The work has applications in nanotechnology, chemical biology and development of novel therapeutics for genetic diseases such as cancer, diabetes or fragile X syndrome. Selected publications

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Day, H. A., Wright, E. P., MacDonald, C. J., Gates, A. J., Waller, Z. A. E.(2015)Reversible DNA i-motif to hairpin switching induced by copper(II) cationsin Chemical Communications51.pp. 14099-14102 Full Text UEA Repository(Article) Bowater, R., Waller, Z.(2014)DNA Structure Full Text()Waller, Z. A. E., Howell, L. A., Macdonald, C. J., O'Connell, M. A., Searcey, M.(2014)Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)in Biochemical and Biophysical Research Communications447.pp. 128-32 Full Text UEA Repository(Article) Day, H. A., Pavlou, P., Waller, Z. A. E.(2014)i-Motif DNA: Structure, stability and targeting with ligandsin Bioorganic & Medicinal Chemistry22.pp. 4407–4418 Full Text UEA Repository(Article) Day, H. A., Huguin, C., Waller, Z.(2013)Silver cations fold i-motif at neutral pHin Chemical Communications49.pp. 7696 Full Text UEA Repository(Article) Dash, J., Waller, Z., Pantoş, G. D., Balasubramanian, S.(2011)Synthesis and Binding Studies of Novel Diethynyl-Pyridine Amides with Genomic Promoter DNA G-Quadruplexesin Chemistry - A European Journal17.pp. 4571–4581 Full Text UEA Repository(Article) McLuckie, K. I. E., Waller, Z., Sanders, D. A., Alves, D., Rodriguez, R., Dash, J., McKenzie, G. J., Venkitaraman, A. R., Balasubramanian, S.(2011)G-Quadruplex-Binding Benzo[in Journal of the American Chemical Society133.pp. 2658-2663 Full Text UEA Repository(Article) Howell, L., Waller, Z., Bowater, R., O'Connell, M., Searcey, M.(2011)A small molecule that induces assembly of a four way DNA junction at low temperaturein Chemical Communications47.pp. 8262-8264 Full Text UEA Repository(Article) Waller, Z., Sewitz, S. A., Hsu, S. D., Balasubramanian, S.(2009)A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expressionin Journal of the American Chemical Society131.pp. 12628-12633 Full Text UEA Repository(Article) Waller, Z., Shirude, P. S., Rodriguez, R., Balasubramanian, S.(2008)Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognitionin Chemical Communicationspp. 1467-1469 Full Text UEA Repository(Article) Waller, Z., BOWEN, R., EDWARDS, H.(2006)Raman spectroscopic and structural investigation of 1,4-diphenylbuta-1,3-diene and selected monomethyl and dimethyl substituted homologuesin Analytica Chimica Acta580.pp. 47-54 Full Text UEA Repository(Article)