Stokes, Leanne - University of East Anglia

个人简介

Leanne obtained a first class BSc (Dual Honours) in Physiology & Pharmacology from the University of Sheffield in 1999 and continued to study an MRes (MPhil) in Immunology & oncology at the University of Birmingham (2000). She stayed at the University of Birmingham to do a PhD in Immunology under the supervision of Professor John Gordon and Dr Gillian Grafton. Following her interests in ion channels in immune cells, Leanne began a post-doctoral position in the lab of Professor Annmarie Surprenant at the University of Sheffield (2003-2006) investigating purinergic ion channels. A further post-doctoral position at the University of Sydney with Professor James Wiley (2007-2010) led to independence as a research fellow at the University of Sydney (2010-2013) followed by a prestigious Vice Chancellor’s research fellowship at RMIT University in Melbourne (2013-2015).

研究领域

I am interested in the roles ion channels play in the regulation of immune cell signalling. My focus is on the purinergic P2X channel family which are activated by extracellular ATP, in particular P2X7. This ion channel has been implicated in a number of inflammatory disorders and pharmacological interventions may be useful in the design of future therapies. Current projects involve studying natural products for effect on P2X channels including compounds from traditional chinese medicines. I am also interested in the effect natural genetic mutations or polymorphisms can have on ion channels and have spent several years investigating impact of SNPs on P2X7 and P2X4 channel functions.

近期论文

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Stokes, L., Mackenzie, A., Sluyter, R.(2016)Roles of ion channels in immune cellsin Frontiers in Immunology48. Full Text(Editorial)Stokes, L., Spencer, S. J., Jenkins, T. A.(2015)Understanding the role of P2X7 in affective disorders—are glial cells the major players?in Frontiers in Cellular Neuroscience9. Full Text UEA Repository(Article) Dao-Ung, P., Skarratt, K., Fuller, S., Stokes, L.(2015)Paroxetine suppresses recombinant human P2X7 responsesin Purinergic Signalling11.pp. 481-490 Full Text UEA Repository(Article) Helliwell, R., ShioukHuey, C., Dhuna, K., Molero, J., Ye, J., Xue, C., Stokes, L.(2015)Selected ginsenosides of the prptopanaxdiol series are novel positive allosteric modulators of P2X7 receptorsin British Journal of Pharmacology172.pp. 3326-3340 Full Text UEA Repository(Article)