Morris, Christopher - University of East Anglia

个人简介

Chris graduated with an MPharm degree (First Class Honours) from Cardiff University in 2002. He then undertook PhD studies in which he investigated the mechanistic aspects of macromolecule uptake and transport across the lung epithelium. In 2007 Chris assumed a post-doctoral position on the EPSRC-funded Nanomedicine Platform Grant (Departments of Chemistry & Pharmacy, Cardiff University) where he led a small inter-disciplinary research group looking at the design and synthesis of novel nanomedicines for enhanced pulmonary macromolecule delivery. Subsequently, Chris worked with scientists from the Defence & Science Technology Laboratory (Porton Down, UK) on a collaborative project that investigated the bioavailability of antimicrobial peptides following delivery into the intact lung. In September 2010 Chris joined UEA as a Lecturer in Drug Delivery and Pharmaceutics.

研究领域

Chris’ main research interests are in the area of experimental peptide therapeutics (including antimicrobial peptides) focussing specifically on their disposition at biological barriers. Current projects include: The examination of antimicrobial peptide and nanomaterial disposition in the airways The development of polymer-peptide platforms for delivery of biologically active peptide drugs across the mucosal barriers of the gut and the lung Development of cellular and non-cellular model systems for studying macromolecule interactions with mucosal barriers The use of phage display to identify DNA-binding ligands (collaboration with Dr Zoe Waller)

近期论文

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Ulaeto, D. O., Morris, C. J., Fox, M. A., Gumbleton, M., Beck, K.(2016)Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targetsin Antimicrobial Agents and Chemotherapy60.pp. 1984-1991 Full Text UEA Repository(Article) Aljayyoussi, G., Price, D. F., Kreitmeyr, K., Keogh, J. P., Smith, M. W., Gumbleton, M., Morris, C. J.(2015)Absorption of ipratropium and L-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transportersin International Journal of Pharmaceutics496.pp. 834-841 Full Text UEA Repository(Article) Al-Jayyoussi, G., Price, D. F., Francombe, D., Taylor, G., Smith, M. W., Morris, C., Edwards, C. D., Eddershaw, P., Gumbleton, M.(2013)Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockoutin Journal of Pharmaceutical Sciences102.pp. 3382-3394 Full Text UEA Repository(Article) Matthews, I., Gregory, C., Aljayyoussi, G., Morris, C., Mcdonald, I., Hoogendoorn, B., Gumbleton, M.(2013)Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the ratin Environmental Toxicology and Pharmacology35.pp. 461-464 Full Text UEA Repository(Article) Morris, C., Beck, K., Fox, M., Ulaeto, D., Clark, G., Gumbleton, M.(2012)Pegylation of Antimicrobial Peptides Maintains the Active Peptide Conformation, Model Membrane Interactions, and Antimicrobial Activity while Improving Lung Tissue Biocompatibility following Airway Deliveryin Antimicrobial Agents and Chemotherapy56.pp. 3298-3308 Full Text UEA Repository(Article) Morris, C., Smith, M., Griffiths, P., McKeown, N., Gumbleton, M.(2011)Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptidein Journal of Controlled Release151.pp. 83-94 Full Text UEA Repository(Article) Gumbleton, M., Al-Jayyoussi, G., Crandon-Lewis, A., Francombe, D., Kreitmeyr, K., Morris, C., Smith, M.(2010)Spatial expression and functionality of drug transporters in the intact lung: Objectives for further research☆in Advanced Drug Delivery Reviews63.pp. 110-118 Full Text UEA Repository(Article) Griffiths, P., Occhipinti, P., Morris, C., Heenan, R., King, S., Gumbleton, M.(2010)PGSE-NMR and SANS Studies of the Interaction of Model Polymer Therapeutics with Mucinin Biomacromolecules11.pp. 120-125 Full Text UEA Repository(Article)