Matthews, Susan - University of East Anglia

个人简介

Susan gained her BPharm from the University of Nottingham in 1991, qualified as a Pharmacist (RPSGB) in 1992 before receiving her PhD in Medicinal Chemistry, from the University of Bath in 1995 for a thesis entitled "Synthesis of Biodegradable Polymers for Delivery of Diagnostic Agents". She gained Post-Doctoral experience at the Institute of Macromolecular Chemistry, Prague (Royal Society European Fellowship), Johannes Gutenberg Universität, Mainz and the Inorganic Chemistry Laboratory, Oxford before taking up the Kinerton Lectureship of Organic Chemistry at Trinity College, Dublin. She joined the School in April 2003 as Lecturer of Medicinal Chemistry and was promoted to Senior lecturer in 2008. She is currently the Chair of the University South East Asia Dialogue Group and was the Associate Dean for Admissions for the Faculty of Science from 2011 till 2016 2008 - to date Senior Lecturer in Medicinal Chemistry, School of Pharmacy, University of East Anglia 2011 - 2016 Associate Dean For Admissions, Faculty of Science, University of East Anglia 2003 – 2008 Lecturer in Medicinal Chemistry, School of Pharmacy, University of East Anglia 2001-2003 Kinerton Lecturer of Organic Chemistry, School of Chemistry, Trinity College Dublin 1999-2001 Post-Doctoral Research Assistant, Inorganic Chemistry Laboratory, University of Oxford 1997-1999 Post Doctoral Research Fellow, Department of Chemistry, University of Mainz, Germany 1996-1997 Royal Society European Post Doctoral Research Fellow, Institute of Macromolecular Chemistry, Academy of Sciences, Prague, Czech Republic 1992-1995 PhD Medicinal Chemistry, University of Bath 1991-1992 Pre Registration Pharmacist, John Radcliffe Hospital, Oxford 1988 - 1991 BPharm (Hons) Pharmacy. First Class, University of Nottingham

研究领域

Research is focused on the interface between chemistry and biology and particularly on the use of supramolecular systems for drug and gene delivery and in novel antibacterial treatments. Current projects include: Gene delivery through functionalised multicalixarenes Cell imaging using fluorescently labelled macrocycles Anti-adhesives as an approach to antibacterial treatment Site-specific pro-drug systems for new anti-cancer agents New antibiotics related to algae extracts New cation and anion receptors based on calixarenes Synthesis of new macrocyclic systems

近期论文

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Buffet, K., Nierengarten, I., Galanos, N., Gillon, E., Holler, M., Imberty, A., Matthews, S. E., Vidal, S., Vincent, S. P., Nierengarten, J.(2016)Pillar[5]arene-based glycoclusters: synthesis and multivalent binding to pathogenic bacterial lectinsin Chemistry - A European Journal22.pp. 2955-2963 Full Text UEA Repository(Article) Boukerb, A., Rousset, A., Galanos, N., Méar, J., Thépaut, M., Grandjean, T., Gillon, E., Cecioni, S., Abderrahmen, C., Faure, K., Redelberger, D., Kipnis, E., Dessein, R., Havet, S., Darblade, B., Matthews, S., De Bentzmann, S., Guéry, B., Cournoyer, B., Imberty, A., Vidal, S.(2014)Antiadhesive properties of glycoclusters against Pseudomonas aeruginosa lung infectionin Journal of Medicinal Chemistry57.pp. 10275-10289 Full Text UEA Repository(Article) Brissonnet, Y., Ortiz Mellet, C., Morandat, S., Garcia Moreno, M. I., Deniaud, D., Matthews, S., Vidal, S., Sestak, S., El Kirat, K., Gouin, S. G.(2013)Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidasesin Journal of the American Chemical Society135.pp. 18427-18435 Full Text UEA Repository(Article) Cecioni, S., Lalor, R., Blanchard, B., Praly, J., Imberty, A., Matthews, S. E., Vidal, S.(2009)Achieving High Affinity towards a Bacterial Lectin through Multivalent Topological Isomers of Calix[4]arene Glycoconjugatesin Chemistry - A European Journal15.pp. 13232-13240 Full Text UEA Repository(Article) Lalor, R., Baillie-Johnson, H., Redshaw, C., Matthews, S., Mueller, A.(2008)Cellular Uptake of a Fluorescent Calix[4]arene Derivativein Journal of the American Chemical Society130.pp. 2892-2893 Full Text UEA Repository(Article)