个人简介
Education:
Postdoctoral Work: [12/87-9/89] Columbia University, New York, New York
Research Advisor: Professor Ronald Breslow
Research: Mechanistic studies of Ribonuclease A mimics. Detailed kinetics analyses of imidazole catalyzed 3'-5' UpU hydrolysis and isomerization. Synthesis and kinetics studies of bisimidazole -cyclodextrin catalyzed phosphodiester hydrolyses.
Ph.D., Chemistry: [11/87] California Institute of Technology, Pasadena, California
Research Advisor: Professor Robert Grubbs
Research: Mechanistic and theoretical studies of olefin metathesis and ring opening metathesis
polymerizations catalyzed by group IV and VI metals.
B.S., Chemistry: [5/82] California State University, Northridge; GPA= 3.97/4.00
Research Advisor: Professor Edward Rosenberg
Research: Mechanistic studies of ligand fluxuations on clusters.
Teaching Awards:
2010 Regent’s Teaching Awardee, Across the entire Univ. Texas System, Aug. 11th 2010
Graduate Teaching Award, UT Austin: 2003
Election to Academy of Distinguished Teachers, UT Austin: 2000
Outstanding Faculty Award, UT Continuing Education: 1999
Jean Holloway Award for Excellence in Teaching: 1999
College of Natural Sciences Teaching Excellence Award: 1995
Work Experience
Welch Regents Chair of Chemistry, 2014-present
Norman Hackerman Chair of Chemistry, 2002-2014
Chief Scientific Officer, Titralyte, 2012-present
Chief Scientific Officer, Reveal Sciences, 2007-present
Chief Scientific Officer, Beacon Sciences, 2006-present
Norman Hackerman Professorship, University of Texas at Austin, 2000-2011
University Distinguished Teaching Professor, University of Texas at Austin, 2000-present, teaching and independent research.
Professor, University of Texas at Austin, 1999-2000
Associate Professor, University of Texas at Austin, 1995-1999
Assistant Professor, University of Texas at Austin, 1989-1995
Head of Synthetic Organic NMR Facility: Cal. Instit. of Tech. 1984-1987
Responsible for all training, maintenance and special experiment design on a JEOL FX-90 and JEOL GX-400. Extensive experience with 2D NMR, polarization transfer, magnetization transfer and NMR of heavy metals.
Teaching Assistant, Cal. State Univ. Northridge, 1983
Introductory Chemistry Laboratory, both first and second semester.
近期论文
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“Self-propagating amplification reactions for molecular detection and signal amplification: Advantages, pitfalls, and challenges” Xiaolong Sun, Doron Shabat, Scott T. Phillips, Eric V. Anslyn Journal of Physical Organic Chemistry, 2018, 31(8), e3827-e3835. DOI: 10.1002/poc.3827.
“Photography Coupled with Self-Propagating Chemical Cascades: Differentiation and Quantitation of G- and V-Nerve Agent Mimics via Chromaticity” Xiaolong Sun, Alexander A. Boulgakov, Leilani N. Smith, Pedro Metola, Edward M. Marcotte, Eric V. Anslyn ACS Central Science, 2018, 4(7), 854-861. DOI: 10.1021/acscentsci.8b00193. PMID: 30062113
“Di-(2-picolyl)-N-(2-quinolinylmethyl)amine-Functionalized Triarylboron: Lewis Acidity Enhancement and Fluorogenic Discrimination Between Fluoride and Cyanide in Aqueous Solution” Mao-Sen Yuan, Xianchao Du, Zhiqiang Liu, Tianbao Li, Wenji Wang, Eric V. Anslyn, Jinyi Wang Chemistry. A European Journal, 2018, 24(37), 9211-9216. DOI: 10.1002/chem.201800884. PMID: 29709086
“Fingerprinting Non-Terran Biosignatures” Sarah S. Johnson, Eric V. Anslyn, Heather V. Graham, Paul R. Mahaffy, Andrew D. Ellington Astrobiology, 2018, 18(7), 915-922. DOI: 10.1089/ast.2017.1712. PMID: 29634318
“Optical Analysis of Reaction Yield and Enantiomeric Excess: A New Paradigm Ready for Prime Time” Brenden T. Herrera, Samantha L. Pilicer, Eric V. Anslyn, Leo A. Joyce, Christian Wolf J. Am. Chem. Soc., 2018, 140(33), 10385–10401. DOI: 10.1021/jacs.8b06607. PMID: 30059621
“2,2’-Bipyridine and hydrazide containing peptides for cyclization and complex quaternary structural control” Hernandez, E.; Escamilla, P.R.; Kwon, S.-Y.; Partridge, J.; McVeigh, M.; Rivera, S.; Reuther, J.F.; Anslyn, E.V. New J. Chem. 2018, 42, 8557-8582.
“A Versatile Approach to Noncanonical, Dynamic Covalent Single- and Multi-Loop Peptide Macrocycles for Enhancing Antimicrobial Activity” Reuther, James F.; Goodrich, Andrew C.; Escamilla, P. Rogelio; Lu, Tiffany A.; Del Rio, Valarie; Davies, Bryan W.; Anslyn, Eric V. J. Am. Chem. Soc., 2018, ASAP. PMID: 29466660
“Teaching through Research: Alignment of Core Chemistry Competencies and Skills within a Multidisciplinary Research Framework” Eman Ghanem, S. Reid Long, Stacia E. Rodenbusch, Ruth I. Shear, Josh T. Beckham, Kristen Procko, Lauren DePue, Keith J. Stevenson, Jon D. Robertus, Stephen Martin, Bradley Holliday, Richard A. Jones, Eric V. Anslyn, Sarah L. Simmons, Journal of Chemical Education, 2018, 95(2), 248-258. DOI: 10.1021/acs.jchemed.7b00294
“Dynamic Covalent Chemistry within Biphenyl Scaffolds: Reversible Covalent Bonding, Control of Selectivity, and Chirality Sensing with a Single System” Ni Cailing; Zha Daijun; Ye Hebo; Hai Yu; Zhou Yuntao; You Lei; Ni Cailing; Ye Hebo; You Lei; Anslyn Eric V Angewandte Chemie, 2018, 57(5), 1300-1305. PubMed ID: 29239090
“Arresting ‘Loose Bolt’ Internal Conversion from −B(OH) 2 Groups is the Mechanism for Emission Turn-On in ortho-Aminomethylphenylboronic Acid-Based Saccharide Sensors” Sun, Xiaolong; James, Tony D.; Anslyn, Eric V. J. Am. Chem. Soc., 2018 , 140(6), 2348-2354. PubMed ID: 29360350
“Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth” Jose, Jiney; Tavares, Clint D. J.; Ebelt, Nancy D.; Lodi, Alessia; Edupuganti, Ramakrishna; Xie, Xuemei; Devkota, Ashwini K.; Kaoud, Tamer S.; Van Den Berg, Carla L.; Anslyn, Eric V.; Tiziani, Stefano; Bartholomeusz, Chandra; Dalby, Kevin N., ACS Medicinal Chemistry Letters, 2017, 8, 1072-1076
“Differential Array Sensing for Cancer Cell Classification and Novlety Detection” Alexandra M. Gade, Margaret K. Meadows, Andrew D. Ellington, and Eric V. Anslyn, Organic and Biomoluclar Chemistry, 2017, 15, 9866-9874 DOI: 10.1039/c7ob02174g
Sun, X.; Anslyn, E. V. "An Auto-Inductive Cascade for the Optical Sensing of Thiols in Aqueous Media: Application in the Detection of a VX Nerve Agent Mimic." Angew. Chem., Int. Ed. 2017, 56, 9522-9526. DOI: 10.1002/anie.201704472
Culver, H. R.; Sharma, I.; Wechsler, M. E.; Anslyn, E. V.; Peppas, N. A. "Charged poly(N-isopropylacrylamide) nanogels for use as differential protein receptors in a turbidimetric sensor array." Analyst. 2017, 142, 3183-3193. DOI: 10.1039/C7AN00787F
Ghanem, E.; Afsah, S.; Fallah, P. N.; Lawrence, A.; LeBovidge, E.; Raghunathan, S.; Rago, D.; Ramirez, M. A.; Telles, M.; Winkler, M.; Schumm, B.; Makhnejia, K.; Portillo, D.; Vidal, R. C.; Hall, A.; Yeh, D.; Judkins, H.; da Silva, A. A.; Franco, D. W.; Anslyn, E. V. "Differentiation and Identification of Cacha¸ca Wood Extracts Using Peptide-Based Receptors and Multivariate Data Analysis." ACS Sens. 2017, 2, 641-647. DOI: 10.1021/acssensors.6b00809
Beyeh, N. K.; Jo, H. H.; Kolesnichenko, I.; Pan, F.; Kalenius, E.; Anslyn, E. V.; Ras, R. H. A.; Rissanen, K. "Recognition of Viologen Derivatives in Water by N-Alkyl Ammonium Resorcinarene Chlorides." J. Org. Chem. 2017, 82, 5198-5203 10.1021/acs.joc.7b00449
“Boronic Acid Mediated Coupling of Catechols and N-Hydroxylamines: A Bioorthogonal Reaction to Label Peptides” Meadows, M.K.; Roesner, E.K.; Lynch, V.M.; James, T.D.; Anslyn, E.V., Organic Letters, 2017, Online. DOI: 10.1021/acs.orglett.7b01198.
“Dynamic covalent chemistry enables formation of antimicrobial peptide quaternary assemblies in a completely abiotic manner” Reuther, J.F.; Dees, J.L.; Kolesnichenko, I.V.; Hernandez, E.T.; Ukraintsev, D.V; Guduru, R.; Whiteley, M.; Anslyn, E.V., Nature Chemistry, 2017, Online. DOI: 10.1038/nchem.2847
“Tuning thiol addition to squaraines by ortho-substitution and the use of serum albumin” Diehl, K.L.; Bachman, L.; Anslyn, E.V., Dyes and Pigments, 2017, 141, 316-324. DOI: 10.1016.j.dyepig.2016.11.060
“An efficient methodology to introduce o-(aminomethyl)phenyl-boronic acids into peptides: alkylation of secondary amines” Hernandez, E.T.; Kolesnichenko, I.V.; Reuther, J.F.; Anslyn, E.V., New J. Cem. 2017, 41, 126-133. DOI: 10.1039/c6nj02862d
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