Fabian, Laszlo - University of East Anglia

个人简介

László obtained his first degree in Chemistry from the Eötvös Loránd University in Budapest. He joined the crystallography group at the Chemical Research Centre of the Hungarian Academy of Science to pursue a doctoral degree. After completing his PhD in 2000, he remained with the same group as a post-doctoral scientist. He moved to the Cambridge Crystallographic Data Centre in 2006 to work on the design of cocrystals. This work was part of a large collaborative project, the Pfizer Institute for Pharmaceutical Materials Science. He continued his research on pharmaceutical cocrystals at University College Cork before joining UEA in 2011.

研究领域

László’s main research area is the solid state chemistry of pharmaceutical compounds. Drugs can have several solid forms, which have different properties. Current projects focus on predicting what solid forms a particular drug can form, on the design of new multi-component forms (cocrystals, salts, solvates) and on understanding how molecular and structural characteristics influence the properties of solid materials.

近期论文

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Tipduangta, P., Belton, P., Fabian, L., Wang, L. Y., Tang, H., Eddledton, M., Qi, S.(2016)Electrospun polymer blend nanofibers for tuneable drug delivery: the role of transformative phase separation on controlling the release ratein Molecular Pharmaceutics13.pp. 25-39 Full Text UEA Repository(Article) Takieddin, K., Khimyak, Y., Fabian, L.(2016)Prediction of Hydrate and Solvate Formation Using Statistical Modelsin Crystal Growth & Design16.pp. 70-81 Full Text UEA Repository(Article) Eddleston, M., Arhangelskis, M., Fabian, L., Tizzard, G., Coles, S. J., Jones, W.(2016)Investigation of an amide-pseudo amide hydrogen bonding motif within a series of theophylline:amide cocrystalsin Crystal Growth & Design16.pp. 51-58 Full Text UEA Repository(Article) Nartowski, K., Malhotra, D., Hawarden, L., Sibik, J., Iuga, D., Zeitler, J. A., Fabian, L., Khimyak, Y.(2016)19F NMR Spectroscopy as a Highly Sensitive Method for the Direct Monitoring of Confined Crystallization within Nanoporous Materialsin Angewandte Chemie International Edition128.pp. 9050-9054 Full Text UEA Repository(Article) Sarcevica, I., Orola, L., Nartowski, K., Khimyak, Y., Round, A., Fabian, L.(2015)Mechanistic and kinetic insight into spontaneous cocrystallisation of isoniazid and benzoic acidin Molecular Pharmaceutics12.pp. 2981–2992 Full Text UEA Repository(Article) Tipduangta, P., Takieddin, K., Fabian, L., Belton, P., Qi, S.(2015)A New Low Melting-point Polymorph of Fenofibrate Prepared via Talc Induced Heterogeneous Nucleationin Crystal Growth & Design15.pp. 5011–5020 Full Text UEA Repository(Article) Nartowski, K. P., Tedder, J., Braun, D. E., Fabian, L., Khimyak, Y. Z.(2015)Building solids inside nano-space: from confined amorphous through confined solvate to confined ‘metastable’ polymorphin Physical Chemistry Chemical Physics17.pp. 24761-24773 Full Text UEA Repository(Article) Pina, M. F., Zhao, M., Pinto, J. F., Sousa, J. J., Frampton, C. S., Diaz, V., Suleiman, O., Fábián, L., Craig, D. Q. M.(2014)An Investigation into the Dehydration Behavior of Paroxetine HCl Form I Using a Combination of Thermal and Diffraction Methods: The Identification and Characterization of a New Anhydrous Formin Crystal Growth & Design14.pp. 3774-3782 Full Text UEA Repository(Article) Eccles, K., Morrison, R., Stokes, S., O'Mahoney, G., Hayes, J., Kelly, D., O'Boyle, N., Fabian, L., Moynihan, H., Maguire, A., Lawrence, S.(2012)Utilizing Sulfoxide...Iodine Halogen Bonding for Cocrystallizationin Crystal Growth & Design12.pp. 2969-2977 UEA Repository(Article) Fabian, L., Frišcic, T.(2012)Chapter 5. Shape and Polarity in Co-crystal Formation: Database Analysis and Experimental ValidationRoyal Society of Chemistrypp. 89-109ISBN 978-1-84973-158-4 Full Text UEA Repository(Chapter)Galcera, J., Friscic, T., Hejczyk, K., Fabian, L., Clarke, S., Day, G., Molins, E., Jones, W.(2012)Isostructural organic binary-host frameworks with tuneable and diversely decorated inclusion cavitiesin CrystEngComm14.pp. 7898 Full Text UEA Repository(Article) Pina, M., Pinto, J., Sousa, J., Fabian, L., Zhao, M., Craig, D.(2012)Identification and Characterization of Stoichiometric and Nonstoichiometric Hydrate Forms of Paroxetine HCl: Reversible Changes in Crystal Dimensions as a Function of Water Absorptionin Molecular Pharmaceutics9.pp. 3515-3525 Full Text UEA Repository(Article) Štrukil, V., Igrc, M., Fabian, L., Eckert-Maksić, M., Childs, S., Reid, D., Duer, M., Halasz, I., Mottillo, C., Friščić, T.(2012)A model for a solvent-free synthetic organic research laboratory: click-mechanosynthesis and structural characterization of thioureas without bulk solventsin Green Chemistry14.pp. 2462 Full Text UEA Repository(Article) Fabian, L., Hamill, N., Eccles, K., Moynihan, H., Maguire, A., McCausland, L., Lawrence, S.(2011)Cocrystals of Fenamic Acids with Nicotinamidein Crystal Growth & Design11.pp. 3522-3528 Full Text UEA Repository(Article) Eccles, K., Deasy, R., Fabian, L., Braun, D., Maguire, A., Lawrence, S.(2011)Expanding the crystal landscape of isonicotinamide: concomitant polymorphism and co-crystallisationin CrystEngComm13.pp. 6923 Full Text UEA Repository(Article) Eccles, K., Deasy, R., Fabian, L., Maguire, A., Lawrence, S.(2011)The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formationin The Journal of Organic Chemistry76.pp. 1159-1162 Full Text UEA Repository(Article) Kelley, S., Fabian, L., Brock, C.(2011)Failures of fractional crystallization: ordered co-crystals of isomers and near isomersin Acta Crystallographica Section B67.pp. 79-93 Full Text UEA Repository(Article) Beldon, P. J., Fabian, L., Stein, R. S., Thirumurugan, A., Cheetham, A. K., Friščić, T.(2010)Rapid Room-Temperature Synthesis of Zeolitic Imidazolate Frameworks by Using Mechanochemistryin Angewandte Chemie International Edition49.pp. 9640-9643 Full Text UEA Repository(Article) Štrukil, V., Fabian, L., Reid, D. G., Duer, M. J., Jackson, G. J., Eckert-Maksić, M., Friščić, T.(2010)Towards an environmentally-friendly laboratory: dimensionality and reactivity in the mechanosynthesis of metal–organic compoundsin Chemical Communications46.pp. 9191-9193 Full Text UEA Repository(Article) Karki, S., Friščić, T., Fabian, L., Jones, W.(2010)New solid forms of artemisinin obtained through cocrystallisationin CrystEngComm12.pp. 4038 Full Text UEA Repository(Article)