个人简介

Jesús studied Chemistry at the University of Seville (Spain). He then obtained his doctorate working at the Instituto de Investigaciones Químicas (IIQ) of the Consejo Superior de Investigaciones Cientificas and University of Seville, in 2002, in the “Carbohydrate Group” led by Prof. Manuel Martín-Lomas, under the supervision of Dr. Pedro Nieto. His thesis was based on the study of the 3D structures and dynamics of oligosaccharides models of glycosaminoglycans (GAGs) by NMR spectroscopy and molecular dynamics simulations. He then moved to Germany for a three-year postdoctoral stay in the research group of Prof. Thomas Peters at the University of Lübeck, where he got a Marie Curie Intra-European Individual Fellwoship to specialize in ligand-based NMR spectroscopy for protein-ligand interactions, with a focus on molecular recognition of substrates by the human blood group B galactosyltransferase (GTB). After that, he joined back the Carbohydrate Group of IIQ (Seville) in 2006 as a "Juan de la Cierva" postdoctoral scientist, and from 2008 to 2013 he worked at the “Glycosystems Laboratory” of the IIQ as a senior scientist, with a prestigious "Ramón y Cajal" award, on NMR and computational chemistry for the study of the interactions of glycosaminoglycans, glycomimetics, and gold glyconanoparticles with protein receptors of relevance in infection processes (anti-HIV-1 2G12 antibody, DC-SIGN and langerin lectins). From September 2012 to September 2013 he is the Secretary of the NMR Group of the Spanish Royal Society of Chemistry. Jesus joined the School of Pharmacy of the University of East Anglia in August 2013 as a Research Fellow and is currently a Lecturer in NMR Spectroscopy since August 2016 within the research area of Drug Delivery and Pharmaceutical Materials.

研究领域

Structural characterization of Ligand-Receptor interactions by NMR Spectroscopy Carbohydrate-Protein interactions. Carbohydrates in drug-delivery. Drug-carrier interactions Ligand-based NMR for “in-cell” ligand-protein interactions - Structure and dynamics of biologically active small/medium-sized molecules

Jesús main research interests focus on the structural and dynamics characterization of biologically active molecules, with a particular focus on glycans, and the molecular recognition of ligands by receptors of both kinds, natural (proteins, nucleic acids,…), or non-natural (materials), heavily relying on NMR spectroscopy and computational techniques.

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Angulo, J., Goffin, S., Gandhi, D., Searcey, M., Howell, L.(2016)Unveiling the "Three Finger Pharmacophore" required for p53-MDM2 Inhibition by Saturation Transfer Difference NMR Initial Growth Rates Approachin Chemistry - A European Journal22.pp. 5858-5862 Full Text UEA Repository(Article) Guzzi, C., Alfarano, P., Sutkeviciute, I., Sattin, S., Ribeiro-viana, R., Fieschi, F., Bernardi, A., Weiser, J., Rojo, J., Angulo, J., Nieto, P. M.(2016)Detection and Quantitative Analysis of Two Independent Binding Modes of a Small Ligand Responsible for DC-SIGN Clusteringin Organic & Biomolecular Chemistry14.pp. 335-344 Full Text UEA Repository(Article) Quiros, M. T., Angulo, J., Muñoz, M. P.(2015)Kinetics of Intramolecular Chemical Exchange by Initial Growth Rates of Spin Saturation Transfer Difference Experiments (SSTD NMR)in Chemical Communications51.pp. 10222-10225 Full Text UEA Repository(Article) Muñoz-García, J. C., Chabrol, E., Vives, R. R., Thomas, A., de Paz, J. L., Rojo, J., Imberty, A., Fieschi, F., Nieto, P. M., Angulo, J.(2015)Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experimentsin Journal of the American Chemical Society137.pp. 4100-4110 Full Text UEA Repository(Article) Thépaut, M., Guzzi, C., Sutkeviciute, I., Sattin, S., Ribeiro-Viana, R., Varga, N., Chabrol, E., Rojo, J., Bernardi, A., Angulo, J., Nieto, P. M., Fieschi, F.(2013)Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C-type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Designin Journal of the American Chemical Society135.pp. 2518-2529 Full Text UEA Repository(Article) Sánchez-Fernández, E. M., Rísquez-Cuadro, R., Ortiz Mellet, C., García Fernández, J. M., Nieto, P. M., Angulo, J.(2012)sp2-Iminosugar O-, S-, and N-glycosides as conformational mimics of α-linked disaccharides; implications for glycosidase inhibitionin Chemistry - A European Journal18.pp. 8527-8539 Full Text UEA Repository(Article) Angulo, J., Enríquez-navas, P., Nieto, P.(2010)Ligand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Ratesin Chemistry - A European Journal16.pp. 7803-7812 Full Text UEA Repository(Article) Angulo, J., Langpap, B., Blume, A., Biet, T., Meyer, B., Krishna, N. R., Peters, H., Palcic, M. M., Peters, T.(2006)Blood Group B Galactosyltransferase: Insights into Substrate Binding from NMR Experimentsin Journal of the American Chemical Society128.pp. 13529-13538 Full Text UEA Repository(Article)