Richards, Chris - University of East Anglia

个人简介

1987. BSc. University of Bath. 1990. PhD. University of Warwick 1990 – 1991. Alexander von Humboldt Fellow, University of Heidelberg 1992 – 2001. Lecturer and Senior Lecturer, Cardiff University 2001 – 2007. Reader, Queen Mary, University of London. Catalysis is a key technology that will enable the sustainable discovery, synthesis and manufacture of new pharmaceuticals, agrochemicals and materials. My approach to achieving these goals involves the design and synthesis of novel organometallic compounds, and to investigate these as catalysts for the efficient enantioselective synthesis of high value chiral organic compounds from low value starting materials. These products are then used to generate new and potentially bioactive chiral heterocycles for application in drug-discovery programmes.

研究领域

Asymmetric organometallic chemistry - synthesis of metallocenes and metallacycles A key activity in the group is the development of methodology for the stereoselective synthesis of chiral non-racemic organometallic complexes. Previous work has included the synthesis of ferrocene-based ligands (e.g. 1) and pincer metallacycles (e.g. 2). Existing work focuses on combining these themes with metallacycle-based metallocenes and related sandwich complexes containing two metals (e.g. 3). In particular, enantioselective C-H activation is being utilised for the simple one-step step synthesis of additional two-metal compounds (e.g. 4 and 5). The potential of novel reactivity and stereochemical control in these complexes as a consequence of metal-metal interaction is under investigation. Asymmetric catalysis and the discovery of new bioactive compounds. The catalytic potential of the complexes synthesised in the group is explored to enable the straightforward generation of valuable chiral compounds in high enantiomeric excess (e.g. the use of 3 for the multigram synthesis of protected allylic amines 6). The methodologies developed are incorporated into sequentially-catalysed reaction protocols for the synthesis of bioactive compounds for collaborative drug discovery programmes.

近期论文

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Arthurs, R. A., Ismail, M., Prior, C. C., Oganesyan, V. S., Horton, P. N., Coles, S. J., Richards, C. J.(2016)Enantiopure Ferrocene-Based Planar-Chiral Iridacycles: Stereospecific Control of Iridium-Centred Chiralityin Chemistry - A European Journal22.pp. 3065-3072 Full Text UEA Repository(Article) Vincent, A., Deschamps, D., Martzel, T., Lohier, J. -., Richards, C. J., Gaumont, A., Perrio, S.(2016)Enantiomerically Pure [2.2]Paracyclophane-4-thiol: A Planar Chiral Sulfur-Based Building Block Readily Available by Resolution with an Amino Acid Chiral Auxiliaryin Journal of Organic Chemistry81.pp. 3961-3966 Full Text(Comment/debate)Arthurs, R. A., Horton, P. N., Coles, S. J., Richards, C. J.(2016)Metallocene to metallocene conversion. Synthesis of an oxazoline-substituted pentamethyliridocenium cation from a ferrocenyloxazolinein Chemical Communications52.pp. 7024-7027 Full Text UEA Repository(Article) Panchal, K., Amin, J., Roca, F. X., Motevalli, M., Horton, P. N., Coles, S. J., Richards, C. J.(2015)Synthesis of racemic palladacycles from 2-ferrocenylphenylphosphinesin Journal of Organometallic Chemistry775.pp. 12-19 Full Text UEA Repository(Article) Amin, J., Motevalli, M., Richards, C. J.(2015)Application of the Nicholas reaction to the synthesis of dicobalt hexacarbonyl complexed diyne ethersin Journal of Organometallic Chemistry776.pp. 43-50 Full Text UEA Repository(Article) Cassar, D. J., Roghzai, H., Villemin, D., Horton, P. N., Coles, S. J., Richards, C. J.(2015)Chirality Control in Planar Chiral Cobalt Oxazoline Palladacyclesin Organometallics34.pp. 2953-2961 Full Text UEA Repository(Article) Cassar, D. J., Ilyashenko, G., Ismail, M., Woods, J., Hughes, D. L., Richards, C. J.(2013)Enantioselective Synthesis and Application to the Allylic Imidate Rearrangement of Amine-Coordinated Palladacycle Catalysts of Cobalt Sandwich Complexesin Chemistry - A European Journal19.pp. 17951-17962 Full Text UEA Repository(Article) Richards, C., Hassan, J.(2012)α-Formylation of α-Substituted Ketonesin Synlett2012.pp. 239-242 Full Text UEA Repository(Article) Amin, J., Richards, C.(2012)Diastereoselective synthesis of half-sandwich chiral-at-metal cobaltacycles by oxidative cyclisationin Chemical Communications48.pp. 10192-10194 Full Text UEA Repository(Article) Cassar, D., Nagaradja, E., Butler, D., Villemin, D., Richards, C.(2012)Regioselective, Stereoselective, and Conformationally Controlled Synthesis of (η4-Tetraarylcyclobutadiene)(η5-carbomethoxycyclopentadienyl)cobalt Metallocenesin Organic Letters14.pp. 894-897 Full Text UEA Repository(Article) Dendele, N., Bisaro, F., Gaumont, A., Perrio, S., Richards, C.(2012)Synthesis of a [2.2]paracyclophane based planar chiral palladacycle by a highly selective kinetic resolution/C–H activation reactionin Chemical Communications48.pp. 1991-1993 Full Text UEA Repository(Article) Gunay, M. E., Hughes, D., Richards, C. J.(2011)Diastereoselective Synthesis of Planar Chiral Cobalt Metallocene Based Oxazoline Platinacyclesin Organometallics30.pp. 3901-3904 Full Text UEA Repository(Article) Spencer, J., Amin, J., Coxhead, P., McGeehan, J., Richards, C. J., Tizzard, G. J., Coles, S. J., Bingham, J. P., Hartley, J. A., Feng, L., Meggers, E., Guille, M.(2011)Size Does Matter. Sterically Demanding Metallocene-Substituted 3-Methylidene-Oxindoles Exhibit Poor Kinase Inhibitory Actionin Organometallics30.pp. 3177-3181 Full Text UEA Repository(Article) Bergin, E., Hughes, D., Richards, C. J.(2010)Application of the Suzuki reaction to the asymmetric desymmetrisation of 1,2-and 1,3-disubstituted bulky cobalt metallocenesin Tetrahedron: Asymmetry21.pp. 1619-1623 Full Text UEA Repository(Article) Gunay, M. E., Ilyashenko, G., Richards, C. J.(2010)Models for the basis of enantioselection in palladium mediated C-H activation reactionsin Tetrahedron: Asymmetry21.pp. 2782-2787 Full Text UEA Repository(Article) Nomura, H., Richards, C. J.(2010)Allylic Imidate Rearrangements Catalyzed by Planar Chiral Palladacyclesin Chemistry - An Asian Journal5.pp. 1726-1740 Full Text UEA Repository(Article) El-Fayyoumy, S., Todd, M. H., Richards, C.(2009)Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approachin Beilstein Journal of Organic Chemistry5.pp. 1726-1740 Full Text UEA Repository(Article) Günay, M. E., Richards, C.(2009)Synthesis of Planar Chiral Phosphapalladacycles byN-Acyl Amino Acid Mediated Enantioselective Palladationin Organometallics28.pp. 5833-5836 Full Text UEA Repository(Article) Ismail, M., Nguyen, H. V., Ilyashenko, G., Motevalli, M., Richards, C. J.(2009)Asymmetric synthesis of oxindoles containing a quaternary stereogenic centre by catalytic O/C-carboxyl rearrangementin Tetrahedron Letters50.pp. 6332-6334 Full Text UEA Repository(Article) Nomura, H., Richards, C.(2009)Asymmetric Synthesis of Unsaturated Monocyclic and Bicyclic Nitrogen Heterocyclesin Organic Letters11.pp. 2892-2895 Full Text UEA Repository(Article)