Brun, Nick Le - University of East Anglia

个人简介

Nick Le Brun graduated in 1990 with a first class degree in Chemistry from UEA. Supported through a Wellcome Trust Prize Studentship, he remained at UEA to begin his research career in the area of bioinorganic chemistry under the guidance of Prof Andrew Thomson, FRS OBE and Prof Geoff Moore. He gained his PhD in 1993, and continued his research in the School through a Wellcome Trust Fellowship. In 1996, he moved to the Department of Microbiology, Lund University, Sweden to take up an EMBO Fellowship, in the laboratory of Prof Lars Hederstedt. In 1999 Nick was appointed as Lecturer in biological chemistry at UEA, and subsequently appointed as Senior Lecturer (2006-2009), Reader (2009-2011), and Professor (2011 - ). Proteins that contain metal ions (metalloproteins) constitute a diverse and hugely important group. By utilising and fine-tuning the wide range of physical and chemical properties exhibited by metal ions, they fulfil many essential roles in many cellular processes. Nick's research interests lie in understanding how bacterial cells handle essential metal ions, the pathways by which metal-containing proteins are assembled, and the reactivities associated with metalloproteins. Nick’s research has been funded over the past few years by BBSRC, The Wellcome Trust and EPRSC. He was a member of the BBSRC Pool of Experts (2009-2010) and served as a core member of BBSRC Committee D: Molecules, Cells and Industrial biotechnology from 2010-13. Since 2010, Nick has been Director of the UEA Centre for Molecular and Structural Biochemistry, and from 2014 he is Chair of the UK's Inorganic Biochemistry Discussion Group (IBDG, an Interest Group of the RSC). In 2015 he became a member of RSC Dalton Council. Nick currently serves on the editorial boards of Journal of Biological Inorganic Chemistry (JBIC) and Microbiology.

研究领域

Nick's research interests lie in understanding how bacterial cells handle essential metal ions, the pathways by which metal-containing proteins are assembled, and the reactivities associated with metalloproteins. Specifically, these are in the following areas: Nitric oxide-sensing iron-sulfur cluster transcriptional regulators Iron storage and release in the bacterial cell The oxygen-sensing global transcription regulator, FNR Bacterial iron-dependent transcriptional regulators Copper trafficking proteins of Bacillus subtilis

近期论文

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Crack, J., Hutchings, M., Thomson, A., Le Brun, N.(2016)Biochemical properties of Paracoccus denitrificans FnrP: Reactions with molecular oxygen and nitric oxidein JBIC Journal of Biological Inorganic Chemistry21.pp. 71-82 Full Text UEA Repository(Article) Bradley, J., Le Brun, N., Moore, G.(2016)Ferritins: furnishing proteins with ironin JBIC Journal of Biological Inorganic Chemistry21.pp. 13-28 Full Text UEA Repository(Article) Crack, J., Svistunenko, D. A., Munnoch, J., Thomson, A., Hutchings, M., Le Brun, N.(2016)Differentiated, promoter-specific response of [4Fe-4S] NsrR DNA-binding to reaction with nitric oxidein Journal of Biological Chemistry291.pp. 8663-8672 Full Text UEA Repository(Article) Kay, K. L., Hamilton, C. J., Le Brun, N. E.(2016)Mass spectrometry ofin Metallomics8.pp. 709-719 Full Text UEA Repository(Article) Munnoch, J. T., Pellicer Martinez, M. T., Svistunenko, D. A., Crack, J. C., Le Brun, N. E., Hutchings, M. I.(2016)Characterization of a putative NsrR homologue in Streptomyces venezuelae reveals a new member of the Rrf2 superfamilyin Scientific Reports6. Full Text UEA Repository(Article) Wong, S., Grigg, J., Le Brun, N., Moore, G., Murphy, M., Mauk, G.(2015)The B-type Channel is a Major Route for Iron Entry into the Ferroxidase Center and Central Cavity of Bacterioferritinin The Journal of Biological Chemistry290.pp. 3732-3739 Full Text UEA Repository(Article) Crack, J., Munnoch, J. T., Dodd, E., Knowles, F., Al-Bassam, M., Kamali, S., Holland, A., Cramer, S., Hamilton, C., Johnson, M., Thomson, A., Hutchings, M., Le Brun, N.(2015)NsrR from Streptomyces coelicolor Is a Nitric Oxide-sensing [4Fe-4S] Cluster Protein with a Specialized Regulatory Functionin The Journal of Biological Chemistry290.pp. 12689-12704 Full Text UEA Repository(Article) Ibrahim, S. A., Crack, J. C., Rolfe, M. D., Borrero-de Acuňa, J. M., Thomson, A. J., Le Brun, N. E., Schobert, M., Stapleton, M. R., Green, J.(2015)Three Pseudomonas putida FNR Family Proteins with Different Sensitivities to O2in The Journal of Biological Chemistry290.pp. 16812-16823 Full Text UEA Repository(Article) Handley, R. A., Mulholland, F., Reuter, M., Ramachandran, V. K., Musk, H., Clissold, L., Le Brun, N. E., van Vliet, A. H. M.(2015)PerR controls oxidative stress defence and aerotolerance but not motility-associated phenotypes of Campylobacter jejuniin Microbiology161.pp. 1524-1536 Full Text UEA Repository(Article) Pfaffen, S., Bradley, J., Abdulqadir, R., Firme, M. R., Moore, G., Le Brun, N., Murphy, M.(2015)A diatom ferritin optimized for iron oxidation but not iron storagein The Journal of Biological Chemistry290.pp. 28416-28427 Full Text UEA Repository(Article) Bradley, J. M., Svistunenko, D. A., Lawson, T. L., Hemmings, A. M., Moore, G. R., Le Brun, N. E.(2015)Three aromatic residues are required for electron transfer during iron mineralization in Bacterioferritinin Angewandte Chemie International Edition127.pp. 14976–14980 Full Text UEA Repository(Article) Bradley, J. M., Moore, G. R., Le Brun, N. E.(2014)Mechanisms of iron mineralization in ferritins: one size does not fit allin JBIC Journal of Biological Inorganic Chemistry19.pp. 775-785 Full Text UEA Repository(Article) Crack, J. C., Green, J., Thomson, A. J., Le Brun, N. E.(2014)Techniques for the production, isolation, and analysis of iron-sulfur proteinsin Methods in Molecular Biology1122.pp. 33-48 Full Text UEA Repository(Article) Crack, J. C., Stapleton, M. R., Green, J., Thomson, A. J., Le Brun, N. E.(2014)Influence of association state and DNA binding on the O2-reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulatorin Biochemical Journal463.pp. 83-92 Full Text UEA Repository(Article) Crack, J. C., Green, J., Thomson, A. J., Le Brun, N. E.(2014)Iron-sulfur clusters as biological sensors: the chemistry of reactions with molecular oxygen and nitric oxidein Accounts of Chemical Research47.pp. 3196-205 Full Text UEA Repository(Article) Le Brun, N.(2014)Binding, Transport and Storage of Copper in ProkaryotesRSC Publishingpp. 461-523ISBN 978-1-84973-599-5(Chapter (peer-reviewed))Pfaffen, S., Abdulqadir, R., Le Brun, N. E., Murphy, M. E. P., Crystallography, X-Ray, Protein Structure, Tertiary(2013)Mechanism of ferrous iron binding and oxidation by ferritin from a pennate diatomin The Journal of Biological Chemistry288.pp. 14917-14925 Full Text UEA Repository(Article) Crack, J. C., Stapleton, M. R., Green, J., Thomson, A. J., Le Brun, N. E.(2013)Mechanism of [4Fe-4S](Cys)4 cluster nitrosylation is conserved among NO-responsive regulatorsin The Journal of Biological Chemistry288.pp. 11492-502 Full Text UEA Repository(Article) Raven, E., McMaster, J., Reedijk, J., Robinson, N. J., Le Brun, N.(2013)Bioinorganic chemistryin Dalton Transactions42.pp. 3027-8 Full Text UEA Repository(Article) Crack, J., Green, J., Hutchings, M., Thomson, A., Le Brun, N.(2012)Bacterial iron-sulfur regulatory proteins as biological sensor-switchesin Antioxidants & Redox Signaling17.pp. 1215-1231 Full Text UEA Repository(Article)