Riley, Graham - University of East Anglia - School of Biological Sciences

个人简介

Graham Riley is a biochemist with a research focus on the molecular pathology of tendon. A graduate of the University of Bristol, he has worked in a number of research areas in both academia and industry, including muscular dystrophy (Pasteur Institute, Paris), haemopoeitic stem cells (Institute of Cancer Research, London) and parasitology (Wellcome Laboratories, Beckenham). He completed his PhD at the Rheumatology Research Unit in Cambridge, investigating the biochemical changes that underlie chronic tendon pathology in the rotator cuff tendons of the shoulder. In 1996 he was appointed Head of the Soft Tissue Research Group at the Rheumatology Research Unit, and formed his own research group to investigate the cell and molecular pathology of tendons, ligaments and fascia. Graham has an international reputation in the field of tendon pathology, and has published a number of key papers. In particular, his work on the role and regulation of metalloproteinases in tendon matrix turnover has resulted in several well-cited publications, and his contribution to the field was recognised by the award of a Senior Research Fellowship from Arthritis Research UK in 2007. He brought his research group to UEA the same year. Career History Arthritis Research UK Senior Research Fellow, University of East Anglia (2007-2012) Head of Soft Tissue Injury and Repair Group, Rheumatology Research Unit (RRU) Addenbrooke’s Hospital, Cambridge (1996-2007) Post-doctoral Research Assistant, RRU, Addenbrooke’s Hospital, Cambridge (1993-1996) Research Assistant, RRU, Addenbrooke’s Hospital, Cambridge (1988-1993) PhD – RRU, Addenbrooke’s Hospital, Cambridge (1993) Research Assistant, Wellcome Laboratories, Beckenham, Kent (1987) Research Assistant, Leukaemia Research Fund Laboratories, London (1984-1986) Research Assistant, Pasteur Institute, Paris, France (1982-1984) BSc - Biochemistry, University of Bristol (1981)

研究领域

My primary research interest is the molecular pathology of soft connective tissues such as tendon and ligament. These tissues are common sites of injury, often affected by long-term pain and prone to rupture, even in non-athletic individuals. Our research uses techniques of cell and molecular biology, histology, immunohistochemistry and biochemistry. We collaborate with clinicians and surgeons at the Norfolk and Norwich Hospital, in particular the Institute of Orthopaedics, to obtain human tissue samples for analysis.

近期论文

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Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R.(2016)Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendonsin Acta Biomaterialia42.pp. 308–315 Full Text UEA Repository(Article) Thorpe, C., Karunaseelan, K., Ng, J., Riley, G., Birch, H., Clegg, P., Screen, H. R. C.(2016)Distribution of proteins within different compartments of tendon varies according to tendon typein Journal of Anatomy229.pp. 450–458 Full Text UEA Repository(Article) Waugh, C., Morrissey, D., Jones, E., Riley, G., Langberg, H., Screen, H.(2015)In vivo biological response to extracorporeal shockwave therapy in human tendinopathy: Response of tendinopathy to shockwave therapyin European Cells and Materials 329.pp. 268-280 UEA Repository(Article) Thorpe, C. T., Godinho, M. S., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R.(2015)The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendonsin Journal of the Mechanical Behavior of Biomedical Materials52.pp. 85-94 Full Text UEA Repository(Article) Spiesz, E. M., Thorpe, C. T., Chaudhry, S., Riley, G. P., Birch, H. L., Clegg, P. D., Screen, H. R. C.(2015)Tendon extracellular matrix damage, degradation and inflammation in response to in-vitro overload exercisein Journal of Orthopaedic Research33.pp. 889–897 Full Text UEA Repository(Article) Shepherd, J., Riley, G., Screen, H., Stress, Mechanical(2014)Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural levelin Journal of the Mechanical Behavior of Biomedical Materials38.pp. 163-172 Full Text UEA Repository(Article) Thorpe, C., Riley, G., Birch, H., Clegg, P., Screen, H.(2014)Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loadingin Journal of The Royal Society Interface11. Full Text UEA Repository(Article) Jones, E. R., Jones, G. C., Legerlotz, K., Riley, G. P.(2013)Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGFβin Biochimica et Biophysica Acta (BBA) - Molecular Cell Research1833.pp. 2596-2607 Full Text UEA Repository(Article) Thorpe, C., Klemt, C., Riley, G., Birch, H., Clegg, P., Screen, H.(2013)Helical sub-structures in energy storing tendons provide a possible mechanism for efficient energy storage and returnin Acta Biomaterialia9.pp. 7948-7956 Full Text UEA Repository(Article) Legerlotz, K., Jones, G., Screen, H., Riley, G.(2013)Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytesin Scandinavian Journal of Medicine & Science in Sports23.pp. 31-37 Full Text UEA Repository(Article) Legerlotz, K., Jones, E., Screen, H., Riley, G.(2012)Increased expression of IL-6 family members in tendon pathologyin Rheumatology51.pp. 1161-1165 Full Text UEA Repository(Article) Corps, A., Robinson, A., Harrall, R., Avery, N., Curry, V., Hazleman, B., Riley, G.(2012)Changes in matrix protein biochemistry and the expression of mRNA encoding matrix proteins and metalloproteinases in posterior tibialis tendinopathyin Annals of the Rheumatic Diseases71.pp. 746-52 Full Text UEA Repository(Article) Riley, G.(2008)Tendinopathy—from basic science to treatmentin Nature Clinical Practice Rheumatology4.pp. 82-89 Full Text UEA Repository(Article) Jones, G., Corps, A., Pennington, C., Clark, I., Edwards, D., Bradley, M., Hazleman, B., Riley, G.(2006)Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendonin Arthritis & Rheumatism54.pp. 832-842 Full Text UEA Repository(Article)