Curtis, Peter - University of East Anglia - Department of Nutrition and Preventive Medicine

个人简介

Senior Research Fellow: Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia: August 2006 to present. Research Associate: Human Nutrition Research Centre, Newcastle University: September 1997 to August 2006. Researcher: The Institute of Food Research, Colney: October 1996 to September 1997. Academic Background PhD Human Nutrition: Newcastle University (2006) M. Med. Sci. Human Nutrition: Sheffield University BA Human Movement Studies (sport and exercise science): 2:1 Leeds Metropolitan University

研究领域

My primary research interest relates to the role of dietary flavonoids (naturally occurring compounds found in foods of plant origin) on health and wellbeing throughout the life course. To this extent, I have a particular interest and track-record in conducting human intervention studies (from acute, single dose studies, to longer-term studies lasting months /years), especially in populations at elevated risk of heart disease and diabetes. My research to date has predominantly focused on the impact of anthocyanins (e.g. berries, and some other fruits and vegetables), isoflavones (e.g. soy), flavanones (e.g. citrus fruits) and flavan-3-ols (e.g. cocoa, tea) and, with colleagues at the Department of Nutrition of Nutrition and Preventive Medicine, our principle focus is cardio-metabolic health and flavonoid bioavailability. Details of our ongoing 6-month dose response blueberry study can be found here: http://www.blueberrystudy.org/. In this study, participants with confirmed metabolic syndrome are being assessed for insulin resistance (directly, and indirectly assessed) and a range of relevant endpoints; including endothelial function, arterial stiffness, cognition, lung function and the interaction with the microbiome (amongst other things). In my role as trial coordinator in studies at UEA I have the fortuitous position of daily interaction with our dedicated study participants, and also benefit from working alongside a range of highly motivated scientists and PhD students, clinicians and research nurses. Alongside my research role, I sit on the Norwich Medical School Research Committee and the Clinical Research Facility Joint Management Group. Previous research experience has included assessing the impact of community based dietary interventions in a broad range of settings and I retain an interest in the role of exercise and activity in disease prevention and recuperation.

近期论文

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Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A., Cassidy, A.(2016)Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trialin The American Journal of Clinical Nutrition103.pp. 694-702 Full Text UEA Repository(Article) Minihane, A. M., Armah, C. K., Miles, E. A., Madden, J. M., Clark, A. B., Caslake, M. J., Packard, C. J., Kofler, B. M., Lietz, G., Curtis, P. J., Mathers, J. C., Williams, C. M., Calder, P. C.(2016)Consumption of Fish Oil Providing Amounts of Eicosapentaenoic cid and Docosahexaenoic Acid That Can Be Obtained from the Diet Reduces Blood Pressure in Adults with Systolic Hypertension: A Retrospective Analysisin Journal of Nutrition146.pp. 516-523 Full Text UEA Repository(Article) Vauzour, D., Tejera, N., O'Neill, C., Booz, V., Jude, B., Wolf, I. M., Rigby, N., Silvan, J. M., Curtis, P. J., Cassidy, A., De Pascual-Teresa, S., Rimbach, G., Minihane, A.(2015)Anthocyanins do not influence long-chain n-3 fatty acid status: Studies in cells, rodents and humansin Journal of Nutritional Biochemistry26.pp. 211-218 Full Text UEA Repository(Article) Schar, M. Y., Curtis, P. J., Hazim, S., Ostertag, L. M., Kay, C. D., Potter, J. F., Cassidy, A.(2015)Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular diseasein The American Journal of Clinical Nutrition101.pp. 931-938 Full Text UEA Repository(Article) de Ferrars, R. M., Cassidy, A., Curtis, P., Kay, C. D.(2014)Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal womenin Molecular Nutrition & Food Research58.pp. 490-502 Full Text UEA Repository(Article) Curtis, P., Potter, J., Kroon, P., Wilson, P., Dhatariya, K., Sampson, M., Cassidy, A.(2013)Vascular function and atherosclerosis progression after 1 y of flavonoid intake in statin-treated postmenopausal women with type 2 diabetes: a double-blind randomized controlled trial.in American Journal of Clinical Nutrition97.pp. 936-42 Full Text UEA Repository(Article) Borel, P., Lietz, G., Goncalves, A., Szabo de Edelenyi, F., Lecompte, S., Curtis, P., Goumidi, L., Caslake, M., Miles, E., Packard, C., Calder, P., Mathers, J., Minihane, A., Tourniaire, F., Kesse-Guyot, E., Galan, P., Hercberg, S., Breidenassel, C., González Gross, M., Moussa, M., Meirhaeghe, A., Reboul, E.(2013)CD36 and SR-BI Are Involved in Cellular Uptake of Provitamin A Carotenoids by Caco-2 and HEK Cells, and Some of Their Genetic Variants Are Associated with Plasma Concentrations of These Micronutrients in Humans.in Journal of Nutrition143.pp. 448-456 UEA Repository(Article) Curtis, P., Sampson, M., Potter, J., Dhatariya, K., Kroon, P., Cassidy, A.(2012)Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: a one year double-blind randomized controlled trial.in Diabetes Care35.pp. 226-232 Full Text UEA Repository(Article) Kofler, B., Miles, E., Curtis, P., Armah, C., Tricon, S., Grew, J., Napper, F., Farrell, L., Lietz, G., Packard, C., Caslake, M., Mathers, J., Williams, C., Calder, P., Minihane, A.(2012)Apolipoprotein E genotype and the cardiovascular disease risk phenotype: Impact of sex and adiposity (the FINGEN study)in Atherosclerosis221.pp. 467-470 Full Text UEA Repository(Article) Curtis, P., Adamson, A., Mathers, J.(2011)Effects on nutrient intake of a family-based intervention to promote increased consumption of low-fat starchy foods through education, cooking skills and personalised goal setting: the Family Food and Health Projectin British Journal of Nutrition12.pp. 1-12 UEA Repository(Article) Falkingham, M., Abdelhamid, A., Curtis, P., Fairweather-Tait, S., Dye, L., Hooper, L., Administration, Oral, Iron, Dietary(2010)The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysisin Nutrition Journal9.pp. 4 Full Text UEA Repository(Article) Curtis, P. J., Kroon, P. A., Hollands, W. J., Walls, R., Jenkins, G., Kay, C. D., Cassidy, A.(2009)Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeksin Journal of Nutrition139.pp. 2266-2271 Full Text UEA Repository(Article) Caslake, M., Miles, E., Kofler, B., Lietz, G., Curtis, P., Armah, C., Kimber, A., Grew, J., Farrell, L., Stannard, J., Napper, F., Sala-Vila, A., West, A., Mathers, J., Packard, C., Williams, C., Calder, P., Minihane, A.(2008)Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study.in American Journal of Clinical Nutrition88.pp. 618-629 UEA Repository(Article)