Vauzour, David - University of East Anglia - Department of Nutrition and Preventive Medicine

个人简介

PhD in Chemical and Biological Sciences for Health, Faculty of Pharmacy, University Montpellier 1, France MSc in Biological and Medical Sciences, Faculty of Pharmacy, University Bordeaux 2, France BSc in Molecular and Cellular Biochemistry/Pharmacology, Faculty of Medicine, University Bordeaux 2, France Member of The Groupe Polyphenols Member of the Biochemical Society Career History Research Fellow, University of East Anglia, UK (2011-present) Post-Doctoral Research Fellow, University of Reading, UK (2008-2011) (BBSRC Fellowship)Post-Doctoral Research Fellow, University of Reading, UK (2005-2008) (MRC Fellowship)

研究领域

Neurodegenerative disorders Phytochemicals Neuroinflammation Memory, learning and neuro-cognitive performances Molecular mechanisms Association between the APOE4 genotype and chronic disease risk My research interest is to develop novel dietary or therapeutic strategies to delay brain ageing, cognitive decline and cardiovascular disease, including stroke and vascular dementia and involves the fields of oxidative stress, free radical biochemistry, neurodegeneration and the health effects of dietary polyphenols, such as flavonoids. Concurrently, my major research interests centre on two functionally associated fields of biomedical sciences: 1) The elucidation of cellular and molecular mechanisms underlying the toxicity exerted by endogenously formed compounds, as well as exogenous agents, believed to be involved in various degenerative diseases; 2) The cellular and molecular principles involved in the protective effects evoked by potentially beneficial natural compounds. Using a variety of experimental models including primary brain cell culture, age-related cognitive decline rodents and human intervention trials, my initial work has provided further insights into the potential for phytochemicals and their in vivo metabolites to promote human vascular function, decrease (neuro)inflammation, enhance memory, learning and neuro-cognitive performances and to slow the progression of Alzheimer’s and Parkinson’s disease pathophysiology. This work has led to substantial knowledge of potential mechanisms of action of phytochemicals based on their modulation of intracellular signalling pathways. In particular, my major contribution has been to show that phytochemicals exert such diverse biological effects through their modulation of intracellular signalling pathways (MAP kinases, PI3 kinase/Akt and Keap-1/Nrf2). My recent interests concern the investigation of the aetiological basis of APOEgenotype-disease associations, and the impact of this common genotype on responsiveness to dietary changes. This work is very much at the translational end of the research spectrum and aligned with the current move towards a more personalised approach to disease prevention and therapeutics.

近期论文

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Rodriguez-Ramiro, I., Vauzour, D., Minihane, A.(2016)Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms: impact and mechanismsCambridgepp. 47-60ISBN 0029-6651 Full Text(Conference contribution) Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A., Minihane, A. M.(2016)A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in micein Journal of Nutrition146.pp. 227-235 Full Text UEA Repository(Article) McManus, S., Tejera, N., Awwad, K., Vauzour, D., Rigby, N., Fleming, I., Cassidy, A., Minihane, A.(2016)Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in menin The Journal of Lipid Research57.pp. 1720-1727 Full Text UEA Repository(Article) Vauzour, D., Camprubi Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., Kiliaan, A. J., Lucca, U., Manach, C., Minihane, A., Mitchell, E. S., Perneczky, R., Perry, H., Roussel, A., Schuermans, J., Sijben, J., Spencer, J. P., Thuret, S., van de Rest, O., Vandewoude, M., Wesnes, K., Williams, R. J., Williams, R. S., Ramirez, M.(2016)Nutrition for the ageing brain: towards evidence for an optimal dietin Ageing Research Reviews Full Text(Scientific review)Vauzour, D., Tejera, N., O'Neill, C., Booz, V., Jude, B., Wolf, I. M., Rigby, N., Silvan, J. M., Curtis, P. J., Cassidy, A., De Pascual-Teresa, S., Rimbach, G., Minihane, A.(2015)Anthocyanins do not influence long-chain n-3 fatty acid status: Studies in cells, rodents and humansin Journal of Nutritional Biochemistry26.pp. 211-218 Full Text UEA Repository(Article) Minihane, A., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M., Vauzour, D., McArdle, H. J., Kremer, B. H. A., Sterkman, L., Vafeiadou, K., Benedetti, M. M., Williams, C. M., Calder, P. C.(2015)Low-grade inflammation, diet composition and health: Current research evidence and its translationin British Journal of Nutrition114.pp. 999-1012 Full Text UEA Repository(Article) Vauzour, D., Martinsen, A., Layé, S.(2015)Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?in Neurochemistry International89.pp. 63-74 Full Text UEA Repository(Article) Angeloni, C., Maraldi, T., Milenkovic, D., Vauzour, D.(2015)Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014in Oxidative Medicine and Cellular Longevity2015. Full Text(Editorial)Achterfeldt, S., Traka, M., Martin, C., Vauzour, D., Kroon, P. A.(2015)Do anthocyanins in purple tomatoes reduce the risk of cardiovascular disease?in Proceedings of the Nutrition Society74.pp. E85 Full Text UEA Repository(Article) Vauzour, D., Vafeiadou, K.(2014)Flavonoids and NeuroinflammationCRC Press UEA Repository(Chapter)Vauzour, D.(2014)Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiologyin Journal of the Science of Food and Agriculture94.pp. 1042–1056 Full Text UEA Repository(Article) Vauzour, D.(2014)Polyphénols et neuroprotection : où en sommes-nous aujourd'hui ?in Cahiers de Nutrition et de Dietetique49.pp. 181–187 Full Text UEA Repository(Article) Maraldi, T., Vauzour, D., Angeloni, C.(2014)Dietary polyphenols and their effects on cell biochemistry and pathophysiology 2013in Oxidative Medicine and Cellular Longevity2014.pp. 576363 Full Text UEA Repository(Article) Vauzour, D., Pinto, J. T., Cooper, A. J. L., Spencer, J. P. E.(2014)The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK-1/JNK1/2 pro-apoptotic signallingin Biochemical Journal463.pp. 41-52 Full Text UEA Repository(Article) Angeloni, C., Maraldi, T., Vauzour, D.(2014)Redox signaling in degenerative diseases: from molecular mechanisms to health implicationsin BioMed Research International2014.pp. 245761 Full Text UEA Repository(Article) Rodriguez-Mateos, A., Vauzour, D., Krueger, C. G., Shanmuganayagam, D., Reed, J., Calani, L., Mena, P., Del Rio, D., Crozier, A.(2014)Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an updatein Archives of Toxicology88.pp. 1803-1853 Full Text UEA Repository(Article) Corona, G., Vauzour, D., Amini, A., Spencer, J.(2014)The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability: An Overviewpp. 591-604ISBN 9780123984562 Full Text UEA Repository(Chapter)Vauzour, D., Buonfiglio, M., Corona, G., Chirafisi, J., Vafeiadou, K., Angeloni, C., Hrelia, S., Hrelia, P., Spencer, J.(2014)Sulforaphane protects cortical neurons against endogenous neurotoxins in a model of Parkinson's diseasepp. 341-348ISBN 9789462610286 UEA Repository(Chapter)Corona, G., Vauzour, D., Hercelin, J., Williams, C., Spencer, J.(2013)Phenolic acid intake, delivered via moderate Champagne wine consumption, improves spatial working memory via the modulation of hippocampal and cortical protein expression/activationin Antioxidants & Redox Signaling19.pp. 1676-1689 Full Text UEA Repository(Article) Eid, N., Al-Awadi, B., Vauzour, D., Oruna-Concha, M., Spencer, J.(2013)The effect of cultivar type and ripening on the polyphenol content of date palm fruitin Journal of Agricultural and Food Chemistry61.pp. 2453–2460 Full Text UEA Repository(Article)