Kay, Colin - University of East Anglia - Department of Nutrition and Preventive Medicine

个人简介

My previous research experience includes 2 year fellowship positions in both the UK and the US and 4 years of research assistantship in Canada. I am trained in nutritional biochemistry (PhD; University of Guelph, Canada) and have also received postdoctoral training in human vascular interventions and controlled dietary feeding trials (Pennsylvania State University, USA). Currently I utilise human and cell-based studies to investigate the effects of diet on disease. Senior Lecturer, Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK (Feb 2012 – present). Lecturer, Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK (Feb 2009 – Feb 2012). Research Associate, Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK (Jan 2007 - Jan 2009). Research Associate - NSERC Postdoctoral Fellow, Co appointment, Departments of Nutritional Sciences and Biobehavioral Health, Penn State University, PA, USA (January 2005 - Dec 2007). Research Associate/Assistant, Pacific Agri-Food Research Center, Department of Agriculture Canada, BC, Canada (January 2003 - January 2005). Graduate Research Assistant, Human Nutrition Laboratory, Department of Human Biology and Nutrition, University of Guelph, ON, Canada (January 2000 - December 2002). Academic Background Ph.D. 2005, University of Guelph, Human Biology and Nutritional Science; Industrial Research location, Pacific Agri-Food Research Centre, BC, Canada. M.Sc. 2002, University of Guelph, Human Biology and Nutritional Science. B.Sc. 2000, University of Guelph, (hons), major in Biological Sciences, minor in Nutrition.

研究领域

Cardiovascular bioactivity of dietary phytochemicals Phytochemical metabolism Dietary Flavonoids

近期论文

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Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A., Cassidy, A.(2016)Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trialin The American Journal of Clinical Nutrition103.pp. 694-702 Full Text UEA Repository(Article) Warner, E. F., Zhang, Q., Raheem, K. S., O'Hagan, D., O'Connell, M. A., Kay, C. D.(2016)Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cellsin Journal of Nutrition146.pp. 465-473 Full Text UEA Repository(Article) Edwards, M., Czank, C., Woodward, G., Cassidy, A., Kay, C.(2015)Phenolic metabolites of anthocyanins modulate mechanisms of endothelial functionin Journal of Agricultural and Food Chemistry63.pp. 2423–2431 Full Text UEA Repository(Article) Amin, H. P., Czank, C., Raheem, S., Zhang, Q., Botting, N. P., Cassidy, A., Kay, C.(2015)Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelialcellsin Molecular Nutrition & Food Research59.pp. 1095–1106 Full Text UEA Repository(Article) Di Gesso, J., Kerr, J., Zhang, Q., Raheem, S., Krishna Yalamanchili, S., O'Hagan, D., Kay, C., O'Connell, M.(2015)Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytesin Molecular Nutrition & Food Research59.pp. 1143–1154 Full Text UEA Repository(Article) Schar, M. Y., Curtis, P. J., Hazim, S., Ostertag, L. M., Kay, C. D., Potter, J. F., Cassidy, A.(2015)Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular diseasein The American Journal of Clinical Nutrition101.pp. 931-938 Full Text UEA Repository(Article) Kay, C.(2015)Rethinking paradigms for studying mechanisms of action of plant bioactivesin Nutrition Bulletin40.pp. 335-339 Full Text UEA Repository(Article) de Ferrars, R. M., Cassidy, A., Curtis, P., Kay, C. D.(2014)Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal womenin Molecular Nutrition & Food Research58.pp. 490-502 Full Text UEA Repository(Article) de Ferrars, R. M., Czank, C., Saha, S., Needs, P. W., Zhang, Q., Raheem, K. S., Kroon, P. A., Kay, C. D., Botting, N. P.(2014)Methods for isolating, identifying and quantifying anthocyanin metabolites in clinical samplesin Analytical Chemistry86.pp. 10052–10058 Full Text UEA Repository(Article) De Ferrars, R. M., Czank, C., Zhang, Q., Botting, N. P., Kroon, P. A., Cassidy, A., Kay, C. D.(2014)The pharmacokinetics of anthocyanins and their metabolites in humansin British Journal of Pharmacology171.pp. 3268-3282 Full Text UEA Repository(Article) Holligan, S. D., West, S. G., Gebauer, S. K., Kay, C. D., Kris-Etherton, P. M.(2014)A moderate-fat diet containing pistachios improves emerging markers of cardiometabolic syndrome in healthy adults with elevated LDL levelsin British Journal of Nutrition112.pp. 744-752 Full Text UEA Repository(Article) Czank, C., Cassidy, A., Zhang, Q., Morrison, D., Preston, T., Kroon, P., Botting, N. P., Kay, C.(2013)Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer studyin American Journal of Clinical Nutrition97.pp. 995-1003 Full Text UEA Repository(Article) Davidson, R. K., Jupp, O., de Ferrars, R., Kay, C. D., Culley, K. L., Norton, R., Driscoll, C., Vincent, T. L., Donell, S. T., Bao, Y., Clark, I. M., Arthritis, Experimental, Cartilage, Articular(2013)Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo: Sulforaphane is protective in the articular Jointin Arthritis and Rheumatism65.pp. 3130-3140 Full Text UEA Repository(Article) Kay, C., Cassidy, A.(2013)Encyclopedia of Human Nutrition: Phytochemicals: Classification and OccurrenceAcademic Presspp. 490-497ISBN 978-0-12-375083-9 Full Text UEA Repository(Chapter)Skinner, M. (ed.), Hunter, D. (ed.), Kay, C.(2013)Bioactives in Fruit: Health Benefits and Functional FoodsJohn Wiley & Sons, LtdISBN 9780470674970 Full Text UEA Repository(Book)Kay, C., Hooper, L., Kroon, P., Rimm, E., Cassidy, A.(2012)Relative impact of flavonoid composition, dose and structure on vascular function: A systematic review of randomised controlled trials of flavonoid-rich food productsin Molecular Nutrition & Food Research56.pp. 1605-1616 Full Text UEA Repository(Article) West, S., Gebauer, S., Kay, C., Bagshaw, D., Savastano, D., Diefenbach, C., Kris-Etherton, P.(2012)Diets Containing Pistachios Reduce Systolic Blood Pressure and Peripheral Vascular Responses to Stress in Adults With Dyslipidemiain Hypertension60.pp. 58-63 Full Text UEA Repository(Article) Cassidy, A., Rimm, E., O'Reilly, E., Logroscino, C., Kay, C., Chiuve, S., Rexrode, K.(2012)Dietary Flavonoids and Risk of Stroke in Womenin Stroke43.pp. 946-951 Full Text UEA Repository(Article) Zhang, Q., Raheem, K. S., Botting, N. P., Slawin, A. M., Kay, C. D., O'Hagan, D.(2012)Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoidsin Tetrahedron68.pp. 4194-4201 Full Text UEA Repository(Article) Hooper, L., Kay, C., Abdelhamid, A., Kroon, P., Cohn, J., Rimm, E., Cassidy, A.(2012)Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trialsin American Journal of Clinical Nutrition95.pp. 740-751 Full Text UEA Repository(Article)