Flather, Marcus - University of East Anglia

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Marcus Flather graduated from the Royal Free Hospital School of Medicine, University of London in 1982 and trained in general medicine and cardiology in London and Oxford. In 1988 he joined the Department of Cardiovascular Medicine and the Clinical Trial Service Unit at the University of Oxford as a British Heart Foundation Junior Research Fellow with Peter Sleight, Rory Collins and Richard Peto working on the large scale ISIS trials in acute myocardial infarction. In 1993 he moved to McMaster University in Hamilton, Canada, to work with Salim Yusuf as a Clinical Research Scholar on international trials in acute coronary syndromes including the OASIS programme, and undertook formal training in clinical trials and epidemiology. In 1996 he took up the post of Director of the new Clinical Trials and Evaluation Unit (CTEU) at the Royal Brompton and Harefield Hospitals where the Unit developed an international reputation in the design and management of randomised trials in cardiovascular and respiratory diseases. In September 2011 he took up the post of Professor of Medicine and Clinical Trials at the University of East Anglia and Director of Research at the Norfolk and Norwich University Hospitals NHS Foundation Trust in Norwich. Marcus Flather is a Fellow of the Royal College of Physicians (UK) and holds a certificate of higher specialist training in Cardiology and General (Internal) Medicine in the UK (CCST). He has about 200 peer reviewed publications, is a recognised expert in clinical trials and has more than 20 years experience of collaborating with industry partners in drug and device development.

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Faris, R., Flather, M., Purcell, H., Poole-Wilson, P., Coats, A.(2016)Diuretics for heart failurein Cochrane Database of Systematic Reviews 20061.pp. CD003838 Full Text UEA Repository(Article) Flather, M. D., Gollop, N. D.(2016)Understanding mechanisms of action of beta-blockers in heart failure with reduced and preserved ejection fractionin JACC: Heart Failure4.pp. 150-151 Full Text(Editorial)Kelion, A. D., Pakkal, M. V., Chowdhury, F. U., Birchall, J. D., Dixon, K. L., Lai, F. Y., Kelly, D. J., Flather, M., McCann, G. P., Gershlick, A. H.(2016)Ischaemia and infarction in STEMI patients with multivessel disease. Insights from the Complete versus Lesion-only PRimary PCI Trial (CvLPRIT) Nuclear Substudyin Journal of the American College of Cardiology67.pp. 2698-2699 Full Text UEA Repository(Article) Williams, M. C., Hunter, A., Shah, A. S., Assi, V., Lewis, S., Smith, J., Berry, C., Boon, N. A., Clark, E., Flather, M., Forbes, J., Mclean, S., Roditi, G., Van Beek, E. J., Timmis, A. D., Newby, D. E.(2016)Use of Coronary Computed Tomographic Angiography to guide management of patients with coronary diseasein Journal of the American College of Cardiology67.pp. 1759-1768 Full Text UEA Repository(Article) Kotecha, D., Manzano, L., Krum, H., Rosano, G., Holmes, J., Altman, D. G., Collins, P. D., Packer, M., Wikstrand, J., Coats, A. J. S., Cleland, J. G. F., Kirchhof, P., Von Lueder, T. G., Rigby, A. S., Andersson, B., Lip, G. Y., Van Veldhuisen, D. J., Shibata, M. C., Wedel, H., Böhm, M., Flather, M. D.(2016)Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysisin BMJ2016. Full Text UEA Repository(Article) Khan, J. N., Greenwood, J. P., Nazir, S. A., Lai, F. Y., Dalby, M., Curzen, N., Hetherington, S., Kelly, D. J., Blackman, D., Peebles, C., Wong, J., Flather, M., Swanton, H., Gershlick, A. H., McCann, G. P.(2016)Infarct Size Following Treatment With Second‐ Versus Third‐Generation P2Y12 Antagonists in Patients With Multivessel Coronary Disease at ST‐Segment Elevation Myocardial Infarction in the CvLPRIT Studyin Journal of the American Heart Association5. Full Text UEA Repository(Article) Kotecha, D., Altman, D. G., Collins, P. D., Flather, M. D.(2016)Authors’ reply to Cunningham and Messerli and colleaguesin BMJ353. Full Text(Letter)Manson-Bahr, D., Ball, R., Gundem, G., Mills, R., Rochester, M., Goody, V., O'Meara, S., Flather, M., Keeling, M., Yazbek Hanna, M., Hurst, R., Curley, H., Clark, J., Brewer, D., Mcdermott, U., Cooper, C.(2015)Mutation Detection in Formalin-Fixed Prostate Cancer Biopsies Taken at the Time of Diagnosis Using Next Generation DNA Sequencingin Journal of Clinical Pathology68.pp. 212-217 Full Text UEA Repository(Article) Gershlick, A. H., Khan, J. N., Kelly, D. J., Greenwood, J. P., Sasikaran, T., Curzen, N., Blackman, D. J., Dalby, M., Fairbrother, K. L., Banya, W., Wang, D., Flather, M., Hetherington, S. L., Kelion, A. D., Talwar, S., Gunning, M., Hall, R., Swanton, H., Mccann, G. P.(2015)Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and Multivessel Diseasein Journal of the American College of Cardiology65.pp. 963-972 Full Text UEA Repository(Article) Mccann, G. P., Khan, J. N., Greenwood, J. P., Nazir, S., Dalby, M., Curzen, N., Hetherington, S., Kelly, D. J., Blackman, D. J., Ring, A., Peebles, C., Wong, J., Sasikaran, T., Flather, M., Swanton, H., Gershlick, A. H.(2015)Complete Versus Lesion-Only Primary PCI: The Randomized Cardiovascular MR CvLPRIT Substudyin Journal of the American College of Cardiology66.pp. 2713-2724 Full Text UEA Repository(Article) Flather, M., Bakhai, A., Perez de Arenaza, D.(2015)Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarctionin New England Journal of Medicine373.pp. 1271-1275 Full Text(Letter)Geisler, T., Booth, J., Tavlaki, E., Karathanos, A., Müller, K., Droppa, M., Gawaz, M., Yanez-lopez, M., Davidson, S. J., Stables, R. H., Banya, W., Zaman, A., Flather, M., Dalby, M.(2015)High Platelet Reactivity in Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: Randomised Controlled Trial Comparing Prasugrel and Clopidogrelin PLoS ONE10. Full Text UEA Repository(Article) Gershlick, A. H., Khan, J. N., Kelly, D. J., Greenwood, J. P., Sasikaran, T., Curzen, N., Blackman, D. J., Dalby, M., Fairbrother, K. L., Banya, W., Wang, D., Flather, M., Hetherington, S. L., Kelion, A. D., Talwar, S., Gunning, M., Hall, R., Swanton, H., Mccann, G. P.(2015)Reply: Complete Revascularization in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI: Is It Really What We Should Be Doing?in Journal of the American College of Cardiology66.pp. 332-333 Full Text(Letter)Khan, R., Lopes, R. D., Neely, M. L., Stevens, S. R., Harrington, R. A., Diaz, R., Cools, F., Jansky, P., Montalescot, G., Atar, D., Lopez-Sendon, J., Flather, M., Liaw, D., Wallentin, L., Alexander, J. H., Goodman, S. G.(2015)Characterising and predicting bleeding in high-risk patients with an acute coronary syndromein Heart101.pp. 1475-1484 Full Text UEA Repository(Article) Pitcher, A., Emberson, J., Lacro, R. V., Sleeper, L. A., Stylianou, M., Mahony, L., Pearson, G. D., Groenink, M., Mulder, B. J., Zwinderman, A. H., De Backer, J., De Paepe, A. M., Arbustini, E., Erdem, G., Jin, X. Y., Flather, M. D., Mullen, M. J., Child, A. H., Forteza, A., Evangelista, A., Chiu, H., Wu, M., Sandor, G., Bhatt, A. B., Creager, M. A., Devereux, R. B., Loeys, B., Forfar, J. C., Neubauer, S., Watkins, H., Boileau, C., Jondeau, G., Dietz, H. C., Baigent, C.(2015)Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaborationin American Heart Journal169.pp. 605-612 Full Text UEA Repository(Article) Kotecha, D., Altman, D. G., Manzano, L., Flather, M. D.(2015)β blockers in patients with heart failure and atrial fibrillation – Authors' replyin The Lancet385.pp. 1618-1619 Full Text(Letter)Montero-Perez-Barquero, M., Manzano, L., Formiga, F., Roughton, M., Coats, A., Rodríguez-Artalejo, F., Diez-Manglano, J., Bettencourt, P., Llacer, P., Flather, M.(2015)Utility of the SENIORS elderly heart failure risk model applied to the RICA registry of acute heart failurein International Journal of Cardiology182.pp. 449-453 Full Text UEA Repository(Article) Khan, J. N., Greenwood, J. P., Nazir, S. A., Dalby, M., Curzen, N., Hetherington, S., Kelly, D., Blackman, D. J., Peebles, C., Wong, J., Flather, M., Gershlick, A., Mccann, G. P.(2015)Predictive value of segmental extent of late gadolinium enhancement and peak circumferential systolic strain in predicting improvement and normalisation of dysfunctional segments post STEMI Full Text(Conference contribution)Taggart, D. P., Altman, D. G., Gray, A. M., Lees, B., Nugara, F., Yu, L., Flather, M.(2015)Effects of on-pump and off-pump surgery in the Arterial Revascularization Trialin European Journal of Cardio-Thoracic Surgery47.pp. 1059-1065 Full Text UEA Repository(Article) Morton, A. C., Rothman, A. M. K., Greenwood, J. P., Gunn, J., Chase, A., Clarke, B., Hall, A. S., Fox, K., Foley, C., Banya, W., Wang, D., Flather, M. D., Crossman, D. C.(2015)The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Studyin European Heart Journal36.pp. 377-384 Full Text UEA Repository(Article)