Livermore, David - University of East Anglia

当前位置： X-MOL首页 › 全球导师 › 海外导师 › Livermore, David

Livermore, David Professor 收藏完善纠错
University of East Anglia Department of Medicine
登录后才能查看导师的联系方式，马上登录...

个人简介

David Livermore gained his BSc in 1978 and his PhD in 1983. He worked at the London Hospital Medical College from 1980 until 1997, when he joined the Health Protection Agency (now Public Health England), becoming Director of its Antibiotic Resistance Monitoring and Reference Laboratory in 1998. In October 2011, he became Professor of Medical Microbiology at UEA, but with 30% of this time supplied back to Public Health England as its Lead on Antibiotic Resistance. Prof Livermore has broad interests on the evolution and dissemination of antibiotic resistance and its relationship to antibiotic prescribing. Beta-Lactamases are a particular interest, with recent work on the proliferation of ‘CTX-M’ extended-spectrum enzymes and carbapenemases, particularly NDM-1, which received extensive media coverage in 2010. He sits on the British Society for Antimicrobial Chemotherapy working parties on resistance surveillance, multi-resistant pathogens and susceptibility testing and its Antibiotic Action advisory board, also on the Society for General Microbiology working group on sexually transmitted infections. He is also a member of the UK Government’s Antimicrobial Resistance and Healthcare Associated Infections Advisory Committee and has contributed extensively to the Chief Medical Offer for England’s Annual Report for 2011. He publishes and speaks widely on resistance and has edited for several journals including Journal of Antimicrobial Chemotherapy and Journal of Medical Microbiology and, currently, International Journal of Antimicrobial Agents. Outside of work, he is a keen walker, has walked the perimeter of Norfolk and almost half the English Coastline. Career History 9/78 to 6/80 QC Microbiology Devt., Wellcome Foundation, Dartford, Kent 6/80 to 8/97 Department of Medical Microbiology, London Hospital Medical College 6/80-11/83 Research Assistant 11/83-2/87 Postdoctoral Fellow (Wellcome Trust) 11/85-5/86 Secondment, Lecturer, University of Hong Kong 2/87-12/94 Lecturer in Medical Microbiology 12/94-8/97 Senior Lecturer in Medical Microbiology 9/97-9/00 Hon Senior Lecturer 9/98-10/11 Public Health England (formerly HPA), Microbiology Services 9/97-9/98 Head, Antibiotic Reference Unit, Colindale 9/98-date Director, Antibiotic Resistance Monitoring & Reference Laboratory, Colindale 10/11-date Professor of Medical Microbiology, University of East Anglia (primary employer, `70% time, with 30% of this subcontracted to Public Health England ) Lead on Antibiotic Resistance, Public Health England Microbiology Services, Colindale Visiting Professor, King Saud University, Riyadh, Saudi Arabia Honorary Professor of Medical Microbiology, Queen Mary University, London Consultant on Antibiotic Resistance – advisory work for numerous diagnostic and pharmaceutical companies and potential investors Academic Background 1978 BSc, (1st. Class Hons) Microbiology, Heriot-Watt University, Edinburgh. 1983 PhD, Medical Microbiology, University of London. Thesis: Resistance mechanisms of Pseudomonas aeruginosa to ?-lactam antibiotics. 2003 State-Registered Clinical Scientist, Health Professions Council (CS1358).

研究领域

My early research centred on ?-lactamases, and I showed how an apparently weak activity could protect a bacterium if the enzyme had high affinity and the ?-lactam permeated only slowly. This led to showing that models describing the interplay of ?-lactamase and permeability were adequate for Escherichia coli but not Pseudomonas aeruginosa, and I contributed to work revealing that this inadequacy was because P. aeruginosa also effluxes ?-lactams. Other early work explored the induction of AmpC ?-lactamases and the selection of AmpC-derepressed mutants from AmpC-inducible populations of Enterobacter and P. aeruginosa, showing selection to be the more important factor. I have been responsible for describing and investigating the properties of many new ?-lactamases, including those conferring resistance to carbapenems – the last reserve ?-lactams against many otherwise multiresistant bacteria. My work increasingly spread from the mechanisms of resistance to its epidemiology. At the UK Health Protection Agency (Public Health England) I led groups that demonstrated the dramatic rises in MRSA in the late 1990s, ciprofloxacin-resistant gonococci around 2002-3, carbapenemase-resistant Acinetobacter spp. and cephalosporin-resistant E. coli from around 2003 and the recent rise in carbapenemases, partly linked to the repeated import of strains with NDM-1 enzyme via patients previously hospitalised in the Indian subcontinent. My current major areas of research interest at UEA centre on the development of methods to rapidly detect antibiotic resistant bacteria in patient specimens. Such tests would allow the swifter optimisation of a patient’s therapy, benefitting both the individual and antibiotic stewardship – thus meeting key objectives highlighted in the Chief Medical Officer’s Annual Report for 2013. Other areas of interest are gut carriage of resistant bacteria and the relationship between in-vitro resistance and treatment outcome, Through on-going links with Public Health England I remain deeply involved in the surveillance of antibiotic resistance, the investigation of emerging resistance types and the in-vitro evaluation of new antibiotics against these organisms.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wilson, A., Livermore, D., Otter, J., Warren, R., Jenks, P., Enoch, D., Newsholme, W., Oppenheim, B., Leanord, A., McNulty, C., Tanner, G., Bennett, S., Cann, M., Bostock, J., Collins, E., Peckitt, S., Ritchie, L., Fry, C., Hawkey, P.(2016)Prevention and control of multi-drug-resistant Gram-negative bacteria: recommendations from a Joint Working Partyin Journal of Hospital Infection92.pp. S1–S44 Full Text UEA Repository(Article) Livermore, D. M., Warner, M., Mushtaq, S., Woodford, N.(2016)Interactions of OP0595, a novel triple-action diazabicyclooctane, with β-lactams against OP0595-resistant Enterobacteriaceae mutantsin Antimicrobial Agents and Chemotherapy60.pp. 554-560 Full Text UEA Repository(Article) Findlay, J., Hopkins, K. L., Doumith, M., Meunier, D., Wiuff, C., Hill, R., Pike, R., Loy, R., Mustafa, N., Livermore, D. M., Woodford, N.(2016)KPC enzymes in the UK: an analysis of the first 160 cases outside the North-West regionin Journal of Antimicrobial Chemotherapy71.pp. 1199-1206 Full Text UEA Repository(Article) Livermore, D. M., Mushtaq, S., Warner, M., Woodford, N.(2016)In-vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumanniiin Antimicrobial Agents and Chemotherapy60.pp. 3840-3844 Full Text UEA Repository(Article) Day, M., Doumith, M., Abernethy, J., Hope, R., Reynolds, R., Wain, J., Livermore, D., Woodford, N.(2016)The population structure of Escherichia coli causing bacteraemia in the UK and Ireland between 2001 and 2010in Journal of Antimicrobial Chemotherapy71.pp. 2139-2142 Full Text UEA Repository(Article) Doumith, M., Mushtaq, S., Livermore, D., Woodford, N.(2016)New insights into the regulatory pathways associated with the activation of the stringent response in bacterial resistance to the PBP2-targeted antibiotics, mecillinam and OP0595/RG6080in Journal of Antimicrobial Chemotherapy71.pp. 2810-2814 Full Text UEA Repository(Article) Benedetti, P., Sefton, A. M., Menegozzo, M., Guerriero, C., Bordignon, G., Da Rin, G., Romualdi, C., Pellizzer, G., Livermore, D. M.(2016)Antimicrobial use and microbiological testing in district general hospital ICUs of the Veneto region of north-east Italyin European Journal of Clinical Microbiology & Infectious Diseases35.pp. 1627–1638 Full Text UEA Repository(Article) Doumith, M., Day, M., Ciesielczuk, H., Hope, R., Underwood, A., Reynolds, R., Wain, J., Livermore, D. M., Woodford, N.(2015)Rapid identification of major Escherichia coli sequence types causing urinary tract and bloodstream infectionsin Journal of Clinical Microbiology53.pp. 160-166 Full Text UEA Repository(Article) Morinaka, A., Tsutsumi, Y., Yamada, M., Suzuki, K., Watanabe, T., Ida, T., Furuuchi, T., Inamura, S., Sakamaki, Y., Mitsuhashi, N., Mitsuhashi, N., Ida, T., Livermore, D.(2015)OP0595, a new diazabicyclooctane: Mode of action as a serine beta-lactamase inhibitor, antibiotic and beta-lactam 'enhancer'in Journal of Antimicrobial Chemotherapy70.pp. 2779-2786 Full Text UEA Repository(Article) Livermore, D., Warner, M., Jamrozy, D., Mushtaq, S., Nichols, W. W., Mustafa, N., Woodford, N.(2015)In-vitro selection of ceftazidime-avibactam resistance in Enterobacteriaceae with KPC-3 carbapenemasein Antimicrobial Agents and Chemotherapy59.pp. 5324-5330 Full Text UEA Repository(Article) Orasch, C., Averbuch, D., Mikulska, M., Cordonnier, C., Livermore, D. M., Gyssens, I. C., Klyasova, G., Engelhard, D., Kern, W., Viscoli, C., Akova, M., Marchetti, O.(2015)Discontinuation of empirical antibiotic therapy in neutropenic leukaemia patients with fever of unknown origin is ethicalin Clinical Microbiology and Infection21.pp. e25-e27 Full Text UEA Repository(Article) Livermore, D. M., Mushtaq, S., Warner, M., James, D., Woodford, N.(2015)Susceptibility testing challenges with ceftaroline, MRSA, and a 1-mg/L breakpointin Journal of Antimicrobial Chemotherapy70.pp. 3259-3266 Full Text UEA Repository(Article) Wright, L., Turton, J. F., Hopkins, K. L., Livermore, D., Woodford, N.(2015)Genetic environment of metallo-β-lactamase genes in Pseudomonas aeruginosa isolates from the UKin Journal of Antimicrobial Chemotherapy70.pp. 3250-3258 Full Text UEA Repository(Article) Cooke, J., Butler, C., Hopstaken, R., Dryden, M. S., McNulty, C., Hurding, S., Moore, M., Livermore, D. M.(2015)Narrative review of primary care point-of-care testing (POCT) and antibacterial use in respiratory tract infection (RTI)in BMJ Open Respiratory Research2. Full Text UEA Repository(Article) Soliman, R., Lynch, S., Meader, E., Pike, R., Turton, J. F., Hill, R. L., Woodford, N., Livermore, D.(2015)Successful ceftolozane/tazobactam treatment of chronic pulmonary infection with pan‐resistant Pseudomonas aeruginosain JMM Case Reports2. Full Text UEA Repository(Article) Stentz, R., Horn, N., Cross, K., Salt, L., Brearley, C., Livermore, D. M., Carding, S. R.(2015)Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against beta-lactam antibioticsin Journal of Antimicrobial Chemotherapy70.pp. 701-709 Full Text UEA Repository(Article) Yazbek Hanna, M., Tremlett, C., Josan, G., Mills, R., Rochester, M., Livermore, D.(2015)Prevalence of ciprofloxacin-resistant Enterobacteriaceae in the intestinal flora of patients undergoing trans-rectal prostate biopsy in Norwich, UKin BJU International116.pp. 131–134 Full Text UEA Repository(Article) Wright, L., Turton, J. F., Livermore, D., Hopkins, K. L., Woodford, N.(2015)Dominance of international ‘high-risk clones’ among Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in the United Kingdomin Journal of Antimicrobial Chemotherapy70.pp. 103-110 Full Text UEA Repository(Article) Livermore, D., Mushtaq, S., Warner, M., James, D., Kearns, A. M., Woodford, N.(2015)Pathogens of skin and skin-structure infections in the UK and their susceptibility to antibiotics, including ceftarolinein Journal of Antimicrobial Chemotherapy70.pp. 2844-2853 Full Text UEA Repository(Article) Livermore, D. M., Mushtaq, S., Warner, M., Woodford, N.(2015)Activity of OP0595-Î²-lactam combination against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing Î²-lactamain Journal of Antimicrobial Chemotherapy70.pp. 3032-3041 UEA Repository(Article)

我收藏的导师 >

最便捷的期刊搜索 >

免费课题组网站 >

推荐链接