Song, Jie - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

研究领域

We aim to understand the mystery of regeneration in plants. Plants are remarkable as small segments like stem cuttings can grow into new plants. Many other creatures do not possess such a capability. After differentiation adult cells are specialised to perform defined tasks, for example, as leaf and root in plants, or brain and muscle in animals. They normally only produce further cells of the same type because the epigenetic information of cell identity is faithfully passed on to the daughter cells. However, as many plants can regenerate a new body from adult cells, such epigenetic memory needs to be reset for adult cells to regain stem cell properties. We use plant (Arabidopsis) regeneration as our model system to study how the epigenetic memory is erased and how cells are reprogrammed towards pluripotency and totipotency. Enquiries about PhD and post-doctoral positions are always welcome.

近期论文

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Questa JI, Song J, Geraldo N, An H, Dean Cet al., 2016, Arabidopsis transcriptional repressor VAL1 triggers Polycomb silencing at FLC during vernalization, SCIENCE, Vol: 353, Pages: 485-488, ISSN: 0036-8075 Angel A, Song J, Yang H, Questa JI, Dean C, Howard Met al., 2015, Vernalizing cold is registered digitally at FLC, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 112, Pages: 4146-4151, ISSN: 0027-8424 Song J, Rutjens B, Dean C, 2014, Detecting histone modifications in plants., Methods Mol Biol, Vol: 1112, Pages: 165-175 Song J, Irwin J, Dean C, 2013, Remembering the Prolonged Cold of Winter, CURRENT BIOLOGY, Vol: 23, Pages: R807-R811, ISSN: 0960-9822 Bodi Z, Zhong S, Mehra S, Song J, Graham N, Li H, May S, Fray RGet al., 2012, Adenosine methylation in Arabidopsis mRNA is associated with the 3 ' end and reduced levels cause developmental defects, FRONTIERS IN PLANT SCIENCE, Vol: 3, ISSN: 1664-462X Coustham V, Li P, Strange A, Lister C, Song J, Dean Cet al., 2012, Quantitative Modulation of Polycomb Silencing Underlies Natural Variation in Vernalization, SCIENCE, Vol: 337, Pages: 584-587, ISSN: 0036-8075 Song J, Angel A, Howard M, Dean Cet al., 2012, Vernalization - a cold-induced epigenetic switch, JOURNAL OF CELL SCIENCE, Vol: 125, Pages: 3723-3731, ISSN: 0021-9533 Angel A, Song J, Dean C, Howard Met al., 2011, A Polycomb-based switch underlying quantitative epigenetic memory, NATURE, Vol: 476, Pages: 105-+, ISSN: 0028-0836 Wilson ZA, Song J, Taylor B, Yang Cet al., 2011, The final split: the regulation of anther dehiscence, JOURNAL OF EXPERIMENTAL BOTANY, Vol: 62, Pages: 1633-1649, ISSN: 0022-0957 Yang C, Xu Z, Song J, Conner K, Barrena GV, Wilson ZAet al., 2007, Arabidopsis MYB26/MALE STERILE35 regulates secondary thickening in the endothecium and is essential for anther dehiscence, PLANT CELL, Vol: 19, Pages: 534-548, ISSN: 1040-4651