Leroi, Armand - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

研究领域

My research mostly concerns the genetic control of growth in the nematode Caenorhabditis elegans. This is the minute worm which formed the basis of the studies for which Sulston, Horvitz and Brenner won the Nobel Prize in 2002. We are particularly interested in how several molecular signalling pathways control the size to which the worm grows (about 1 mm long). We are studying the TGF-beta (DBL-1) pathway, a molecule which is secreted by the worm's ventral nerve cord and appears to act rather like growth hormone. We are investigating the genes that are the target of this pathway, how it influences the cells of growing worms, the size differences between the sexes (hermaphrodite worms are larger than males), and the way in which it mediates signals from the environment. We are also interested in another, quite different, growth control system that we identified in 2002: one that emanates from the worm's gonad. To study these problems we use a variety of standard molecular techniques, including screening for gigantism and dwarfism mutants, and some that are more unique to worms such as laser microsurgery. Our research is not, however, merely motivated by understanding growth in C. elegans. We also want to understand the genetic basis of body size evolution in nematodes. We have a zoo of about 50 species of free-living nematodes that we keep in the laboratory much as we keep C. elegans (on petri dishes eating E. coli), some of which are larger than C. elegans itself. We believe that the TGF-beta pathway is involved in these evolutionary differences. We are also interested in computational models of nematode development. Using software developed by collaborators at DKFZ, Heidelberg and Houston, we are analysing the lineage and three-dimensional topology of embryonic development.

近期论文

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Davies SK, Bundy JG, Leroi AM, 2015, Metabolic Youth in Middle Age: Predicting Aging in Caenorhabditis elegans Using Metabolomics, JOURNAL OF PROTEOME RESEARCH, Vol: 14, Pages: 4603-4609, ISSN: 1535-3893 Mauch M, MacCallum RM, Levy M, Leroi AMet al., 2015, The evolution of popular music: USA 1960-2010, ROYAL SOCIETY OPEN SCIENCE, Vol: 2, ISSN: 2054-5703 Leroi AM, 2014, The Lagoon How Aristotle Invented Science, Publisher: Bloomsbury Publishing, ISBN: 9781408836217 Geier FM, Fuchs S, Valbuena G, Leroi AM, Bundy JGet al., 2013, Profiling the metabolic signature of senescence., Methods Mol Biol, Vol: 965, Pages: 355-371 Davies SK, Leroi AM, Bundy JG, 2012, Fluorodeoxyuridine affects the identification of metabolic responses to daf-2 status in Caenorhabditis elegans, MECHANISMS OF AGEING AND DEVELOPMENT, Vol: 133, Pages: 46-49, ISSN: 0047-6374 MacCallum RM, Mauch M, Burt A, Leroi AMet al., 2012, Evolution of music by public choice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 12081-12086, ISSN: 0027-8424 Casadevall i Solvas X, Geier FM, Leroi AM, Bundy JG, Edel JB, deMello AJet al., 2011, High-throughput age synchronisation of Caenorhabditis elegans, CHEMICAL COMMUNICATIONS, Vol: 47, Pages: 9801-9803, ISSN: 1359-7345 Geier FM, Want EJ, Leroi AM, Bundy JGet al., 2011, Cross-Platform Comparison of Caenorhabditis elegans Tissue Extraction Strategies for Comprehensive Metabolome Coverage, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 3730-3736, ISSN: 0003-2700 Rebbeck CA, Leroi AM, Burt A, 2011, Mitochondrial Capture by a Transmissible Cancer, SCIENCE, Vol: 331, Pages: 303-303, ISSN: 0036-8075 Fuchs S, Bundy JG, Davies SK, Viney JM, Swire JS, Leroi AMet al., 2010, A metabolic signature of long life in Caenorhabditis elegans, BMC BIOLOGY, Vol: 8, ISSN: 1741-7007 Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt Aet al., 2009, ORIGINS AND EVOLUTION OF A TRANSMISSIBLE CANCER, EVOLUTION, Vol: 63, Pages: 2340-2349, ISSN: 0014-3820 Swire J, Fuchs S, Bundy JG, Leroi AMet al., 2009, The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegans, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 276, Pages: 2747-2754, ISSN: 0962-8452 Thomas R, Rebbeck C, Leroi AM, Burt A, Breen Met al., 2009, Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis, CHROMOSOME RESEARCH, Vol: 17, Pages: 927-934, ISSN: 0967-3849 Leroi AM, 2008, Creationism and its critics in antiquity, NATURE, Vol: 452, Pages: 153-153, ISSN: 0028-0836 Tain LS, Lozano E, Saez AG, Leroi AMet al., 2008, Dietary regulation of hypodermal polyploidization in C-elegans, BMC DEVELOPMENTAL BIOLOGY, Vol: 8, ISSN: 1471-213X Leroi AM, 2007, Armand Leroi - Q&A, CURRENT BIOLOGY, Vol: 17, Pages: R619-R620, ISSN: 0960-9822 Leroi AM, 2006, The future of neo-eugenics, EMBO REPORTS, Vol: 7, Pages: 1184-1187, ISSN: 1469-221X Leroi AM, Swire J, 2006, The recovery of the past, WORLD OF MUSIC, Vol: 48, Pages: 43-54, ISSN: 0043-8774 Lozano E, Saez AG, Flemming AJ, Cunha A, Leroi AMet al., 2006, Regulation of growth by ploidy in Caenorhabditis elegans, CURRENT BIOLOGY, Vol: 16, Pages: 493-498, ISSN: 0960-9822 Azevedo RBR, Lohaus R, Braun V, Gumbel M, Umamaheshwar M, Agapow PM, Houthoofd W, Platzer U, Borgonie G, Meinzer HP, Leroi AMet al., 2005, The simplicity of metazoan cell lineages, NATURE, Vol: 433, Pages: 152-156, ISSN: 0028-0836