Guerra, Nadia - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

个人简介

Dr Guerra established her lab in the Department of Life Sciences in October 2009 as a Wellcome Trust fellow and was appointed as a lecturer/assistant Professor in February 2013. Her research aims to elucidate the physiologic relevance of immunoreceptors expressed by Natural Killer (NK) cells in the development of immunopathologies and cancer. An additional focus in the lab relies on combining state-of-the-art multi-photon imaging with novel mouse models to investigate the behavior of NK cells during chronic inflammation with the view of understanding the role they play in cancer progression. Nadia received her Ph.D. from the University Paris VI, Pierre et Marie Curie, Paris in 2002 where she studied the role of inhibitory NK cell receptors in kidney cancer at the Institut Gustave Roussy in Villejuif, France. She joined the group of Prof. David Raulet at the University of Berkeley, California to complete her postdoctoral training focusing on the role of NK group 2, member D (NKG2D) in vivo. She made a significant contribution to the NK cell field through the generation of NKG2D-deficient mice, instrumental to the understanding of NK cell function in disease models.

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Collery P, Mohsen A, Kermagoret A, Corre S, Bastian G, Tomas A, Wei M, Santoni F, Guerra N, Desmaele D, d'Angelo Jet al., 2015, Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer, INVESTIGATIONAL NEW DRUGS, Vol: 33, Pages: 848-860, ISSN: 0167-6997 Sparks H, Warren S, Guedes J, Yoshida N, Charn TC, Guerra N, Tatla T, Dunsby C, French Pet al., 2015, A flexible wide-field FLIM endoscope utilising blue excitation light for label-free contrast of tissue, JOURNAL OF BIOPHOTONICS, Vol: 8, Pages: 168-178, ISSN: 1864-063X Basey-Fisher TH, Guerra N, Triulzi C, Gregory A, Hanham SM, Stevens MM, Maier SA, Klein Net al., 2014, Microwaving Blood as a Non-Destructive Technique for Haemoglobin Measurements on Microlitre Samples, ADVANCED HEALTHCARE MATERIALS, Vol: 3, Pages: 536-542, ISSN: 2192-2640 Basey-Fisher TH, Guerra N, Triulzi C, Gregory A, Hanham SM, Stevens MM, Maier SA, Klein Net al., 2014, Blood measurements: microwaving blood as a non-destructive technique for haemoglobin measurements on microlitre samples (adv. Healthcare mater. 4/2014)., Adv Healthc Mater, Vol: 3 Farhadi N, Lambert L, Triulzi C, Openshaw PJM, Guerra N, Culley FJet al., 2014, Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 133, Pages: 827-+, ISSN: 0091-6749 Guerra N, Pestal K, Juarez T, Beck J, Tkach K, Wang L, Raulet DHet al., 2013, A selective role of NKG2D in inflammatory and autoimmune diseases, CLINICAL IMMUNOLOGY, Vol: 149, Pages: 432-439, ISSN: 1521-6616 Klein N, Basey-Fisher TH, Otter WJ, Guerra N, Triulzi C, Gregory A, Hanham SM, Lucyscyn Set al., 2013, TOWARDS MICROWAVE AND MILLIMTER WAVE BIOSENSORS, International Kharkov Symposium on Physics and Engineering of Microwaves, Millimeter and Submillimeter Waves (MSMW), Publisher: IEEE, Pages: 509-510 Sheppard S, Triulzi C, Ardolino M, Serna D, Zhang L, Raulet DH, Guerra Net al., 2013, Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire, BLOOD, Vol: 121, Pages: 5025-5033, ISSN: 0006-4971 Xia M, Guerra N, Sukhova GK, Yang K, Miller CK, Shi G-P, Raulet DH, Xiong Net al., 2011, Immune Activation Resulting From NKG2D/Ligand Interaction Promotes Atherosclerosis, CIRCULATION, Vol: 124, Pages: 2933-U419, ISSN: 0009-7322 Xia M, Yang K, Guerra N, Sukhova G, Miller C, Shi G-P, Raulet D, Xiong Net al., 2010, NKG2D/ligands-mediated immune activation promotes atherosclerosis, JOURNAL OF IMMUNOLOGY, Vol: 184, ISSN: 0022-1767 Raulet DH, Guerra N, 2009, Oncogenic stress sensed by the immune system: role of natural killer cell receptors, NATURE REVIEWS IMMUNOLOGY, Vol: 9, Pages: 568-580, ISSN: 1474-1733 Whang MI, Guerra N, Raulet DH, 2009, Costimulation of Dendritic Epidermal gamma delta T Cells by a New NKG2D Ligand Expressed Specifically in the Skin, JOURNAL OF IMMUNOLOGY, Vol: 182, Pages: 4557-4564, ISSN: 0022-1767 Guerra N, Tan YX, Joncker NT, Choy A, Gallardo F, Xiong N, Knoblaugh S, Cado D, Greenberg NR, Raulet DHet al., 2008, NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy, IMMUNITY, Vol: 28, Pages: 571-580, ISSN: 1074-7613 Gati A, Da Rocha S, Guerra N, Escudier B, Moretta A, Chouaib S, Angevin E, Caignard Aet al., 2004, Analysis of the natural killer mediated immune response in metastatic renal cell carcinoma patients, INTERNATIONAL JOURNAL OF CANCER, Vol: 109, Pages: 393-401, ISSN: 0020-7136 Gati A, Dorothee G, Thiery J, Guerra N, Richon C, Gaudin C, Mami-Chouaib F, Caignard A, Diarra-Mehrpour M, Chouaib Set al., 2003, Tumor/cytotoxic effector cross-talk in the control of tumor susceptibility to lysis, BULLETIN DU CANCER, Vol: 90, Pages: 686-694, ISSN: 0007-4551 Gati A, Guerra N, Gaudin C, Da Rocha S, Escudier B, Lecluse Y, Bettaieb A, Chouaib S, Caignard Aet al., 2003, CD158 receptor controls cytotoxic T-lymphocyte susceptibility to tumor-mediated activation-induced cell death by interfering with fas signaling, CANCER RESEARCH, Vol: 63, Pages: 7475-7482, ISSN: 0008-5472 Chouaib S, Thiery J, Gati A, Guerra N, El Behi M, Dorothee G, Mami-Chouaib F, Bellet D, Caignard Aet al., 2002, Tumor escape from killing: Role of killer inhibitory receptors and acquisition of tumor resistance to cell death, TISSUE ANTIGENS, Vol: 60, Pages: 273-281, ISSN: 0001-2815 Guerra N, Michel F, Gati A, Gaudin C, Mishal Z, Escudier B, Acuto O, Chouaib S, Caignard Aet al., 2002, Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction, BLOOD, Vol: 100, Pages: 2874-2881, ISSN: 0006-4971 Chouaib S, Echchakir H, Angevin E, Guerra N, Kosmatopoulos K, Caignard A, Lim A, Baron V, Ferradini L, Mami-Chouaib Fet al., 2001, Technological advances in immuno-oncology: from fundamental concepts to patient immunological monitoring, BULLETIN DU CANCER, Vol: 88, Pages: 733-740, ISSN: 0007-4551 Gati A, Guerra N, Giron-Michel J, Azzarone B, Angevin E, Moretta A, Chouaib S, Caignard Aet al., 2001, Tumor cells regulate the lytic activity of tumor-specific cytotoxic T lymphocytes by modulating the inhibitory natural killer receptor function, CANCER RESEARCH, Vol: 61, Pages: 3240-3244, ISSN: 0008-5472