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研究领域

Homing Endonuclease Genes (HEGs). We have been studying the evolutionary dynamics of these nonMendelian selfish genes, particularly in yeasts. Population Genetic Engineering. I am interested in using selfish genetic elements to genetically manipulate natural populations; our first targets are the mosquitoes that transmit malaria. Population Genomics and Phylogenetics of Yeasts. The tremendous amount that is known about the biochemistry, genetics, and cell biology of yeasts makes them ideal model systems for addressing questions in evolutionary and population biology. Molecular Ecology of a Pathogenic Mammal. Canine Transmissible Venereal Tumor (CTVT) is a sexually transmitted parasitic cell line currently circulating in feral dog populations; we are interested in its origins and how it has adapted to its new way of life.

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Beaghton A, Beaghton PJ, Burt A, 2016, Gene drive through a landscape: Reaction-diffusion models of population suppression and elimination by a sex ratio distorter, THEORETICAL POPULATION BIOLOGY, Vol: 108, Pages: 51-69, ISSN: 0040-5809 Davies SK, Leroi A, Burt A, Bundy JG, Baer CFet al., 2016, The mutational structure of metabolism in Caenorhabditis elegans., Evolution, Vol: 70, Pages: 2239-2246, ISSN: 0014-3820 Deredec A, O'Loughlin SM, Hui T-YJ, Burt Aet al., 2016, Partitioning the contributions of alternative malaria vector species, MALARIA JOURNAL, Vol: 15, ISSN: 1475-2875 Hammond A, Galizi R, Kyrou K, Simoni A, Siniscalchi C, Katsanos D, Gribble M, Baker D, Marois E, Russell S, Burt A, Windbichler N, Crisanti A, Nolan Tet al., 2016, A CRISPR-Cas9 gene drive system-targeting female reproduction in the malaria mosquito vector Anopheles gambiae, NATURE BIOTECHNOLOGY, Vol: 34, Pages: 78-83, ISSN: 1087-0156 O'Loughlin SM, Magesa SM, Mbogo C, Mosha F, Midega J, Burt Aet al., 2016, Genomic signatures of population decline in the malaria mosquito Anopheles gambiae, MALARIA JOURNAL, Vol: 15, ISSN: 1475-2875 Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger Jet al., 2015, Safeguarding gene drive experiments in the laboratory, SCIENCE, Vol: 349, Pages: 927-929, ISSN: 0036-8075 Hui T-YJ, Burt A, 2015, Estimating Effective Population Size from Temporally Spaced Samples with a Novel, Efficient Maximum-Likelihood Algorithm, GENETICS, Vol: 200, Pages: 285-293, ISSN: 0016-6731 Koufopanou V, Lomas S, Tsai IJ, Burt Aet al., 2015, Estimating the Fitness Effects of New Mutations in the Wild Yeast Saccharomyces paradoxus, GENOME BIOLOGY AND EVOLUTION, Vol: 7, Pages: 1887-1895, ISSN: 1759-6653 Neafsey DE, Waterhouse RM, Abai MR, Aganezov SS, Alekseyev MA, Allen JE, Amon J, Arca B, Arensburger P, Artemov G, Assour LA, Basseri H, Berlin A, Birren BW, Blandin SA, Brockman AI, Burkot TR, Burt A, Chan CS, Chauve C, Chiu JC, Christensen M, Costantini C, Davidson VLM, Deligianni E, Dottorini T, Dritsou V, Gabriel SB, Guelbeogo WM, Hall AB, Han MV, Hlaing T, Hughes DST, Jenkins AM, Jiang X, Jungreis I, Kakani EG, Kamali M, Kemppainen P, Kennedy RC, Kirmitzoglou IK, Koekemoer LL, Laban N, Langridge N, Lawniczak MKN, Lirakis M, Lobo NF, Lowy E, MacCallum RM, Mao C, Maslen G, Mbogo C, McCarthy J, Michel K, Mitchell SN, Moore W, Murphy KA, Naumenko AN, Nolan T, Novoa EM, O'Loughlin S, Oringanje C, Oshaghi MA, Pakpour N, Papathanos PA, Peery AN, Povelones M, Prakash A, Price DP, Rajaraman A, Reimer LJ, Rinker DC, Rokas A, Russell TL, Sagnon N, Sharakhova MV, Shea T, Simao FA, Simard F, Slotman MA, Somboon P, Stegniy V, Struchiner CJ, Thomas GWC, Tojo M, Topalis P, Tubio JMC, Unger MF, Vontas J, Walton C, Wilding CS, Willis JH, Wu Y-C, Yan G, Zdobnov EM, Zhou X, Catteruccia F, Christophides GK, Collins FH, Cornman RS, Crisanti A, Donnelly MJ, Emrich SJ, Fontaine MC, Gelbart W, Hahn MW, Hansen IA, Howell PI, Kafatos FC, Kellis M, Lawson D, Louis C, Luckhart S, Muskavitch MAT, Ribeiro JM, Riehle MA, Sharakhov IV, Tu Z, Zwiebel LJ, Besansky NJet al., 2015, Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes, SCIENCE, Vol: 347, ISSN: 0036-8075 Samani P, Low-Decarie E, McKelvey K, Bell T, Burt A, Koufopanou V, Landry CR, Bell Get al., 2015, Metabolic variation in natural populations of wild yeast, ECOLOGY AND EVOLUTION, Vol: 5, Pages: 722-732, ISSN: 2045-7758 Burt A, 2014, Heritable strategies for controlling insect vectors of disease, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 369, ISSN: 0962-8436 Galizi R, Doyle LA, Menichelli M, Bernardini F, Deredec A, Burt A, Stoddard BL, Windbichler N, Crisanti Aet al., 2014, A synthetic sex ratio distortion system for the control of the human malaria mosquito, NATURE COMMUNICATIONS, Vol: 5, ISSN: 2041-1723 Harrison E, MacLean RC, Koufopanou V, Burt Aet al., 2014, Sex drives intracellular conflict in yeast, JOURNAL OF EVOLUTIONARY BIOLOGY, Vol: 27, Pages: 1757-1763, ISSN: 1010-061X Murchison EP, Wedge DC, Alexandrov LB, Fu B, Martincorena I, Ning Z, Tubio JMC, Werner EI, Allen J, De Nardi AB, Donelan EM, Marino G, Fassati A, Campbell PJ, Yang F, Burt A, Weiss RA, Stratton MRet al., 2014, Transmissable Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage, SCIENCE, Vol: 343, Pages: 437-440, ISSN: 0036-8075 O'Loughlin SM, Magesa S, Mbogo C, Mosha F, Midega J, Lomas S, Burt Aet al., 2014, Genomic Analyses of Three Malaria Vectors Reveals Extensive Shared Polymorphism but Contrasting Population Histories, MOLECULAR BIOLOGY AND EVOLUTION, Vol: 31, Pages: 889-902, ISSN: 0737-4038 Koufopanou V, Swire J, Lomas S, Burt Aet al., 2013, Primers for fourteen protein-coding genes and the deep phylogeny of the true yeasts, FEMS YEAST RESEARCH, Vol: 13, Pages: 574-584, ISSN: 1567-1356 North A, Burt A, Godfray HCJ, 2013, Modelling the spatial spread of a homing endonuclease gene in a mosquito population, JOURNAL OF APPLIED ECOLOGY, Vol: 50, Pages: 1216-1225, ISSN: 0021-8901 O'Loughlin S, Burt A, 2013, INFERRING DEMOGRAPHY AND SELECTION IN EAST AFRICAN ANOPHELES GAMBIAE SL FROM GENOME WIDE SNPS, PATHOGENS AND GLOBAL HEALTH, Vol: 107, Pages: 416-416, ISSN: 2047-7724 Harrison E, Koufopanou V, Burt A, Maclean RCet al., 2012, The cost of copy number in a selfish genetic element: the 2-mu M plasmid of Saccharomyces cerevisiae, JOURNAL OF EVOLUTIONARY BIOLOGY, Vol: 25, Pages: 2348-2356, ISSN: 1010-061X Klein TA, Windbichler N, Deredec A, Burt A, Benedict MQet al., 2012, Infertility resulting from transgenic I-PpoI male Anopheles gambiae in large cage trials, PATHOGENS AND GLOBAL HEALTH, Vol: 106, Pages: 20-31, ISSN: 2047-7724

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