Bozkurt, Tolga - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

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Many filamentous plant pathogens including fungi and oomycetes are accommodated within the host cells through specialized cellular structures. For instance, some filamentous plant pathogens form specialized infection structures termed haustoria to deliver effector proteins that can modulate host immunity or mediate nutrient uptake. However, little is known about molecular mechanisms underlying microbial accommodation inside the plant cells. Our aim is to characterize the host processes required for accommodation of filamentous plant pathogens inside the plant cells with a specific focus on illustrating the role of plant endomembrane transport system and identify perturbations caused by the pathogens. These processes have been difficult to dissect using standard genetic approaches due to overlap between focal immunity and plant development. We recently discovered that some of the Pathogen secreted effectors specifically accumulate around haustoria (perihaustorial effectors) and provide an excellent alternative to study plant focal immunity (Bozkurt et al., 2011, Saunders et al., 2012). We deploy perihaustorial effectors as molecular probes and use a multifaceted approach including cell biology, biochemical and genetic methods to investigate the mechanisms and perturbations in host endomembrane system within the plant cells that accommodate haustoria.

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Dagdas YF, Belhaj K, Maqbool A, Chaparro-Garcia A, Pandey P, Petre B, Tabassum N, Cruz-Mireles N, Hughes RK, Sklenar J, Win J, Menke F, Findlay K, Banfield MJ, Kamoun S, Bozkurt TOet al., 2016, An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor, ELIFE, Vol: 5, ISSN: 2050-084X Maqbool A, Hughes RK, Dagdas YF, Tregidgo N, Zess E, Belhaj K, Round A, Bozkurt TO, Kamoun S, Banfield MJet al., 2016, Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 291, Pages: 20270-20282, ISSN: 0021-9258 Wu C-H, Belhaj K, Bozkurt TO, Birk MS, Kamoun Set al., 2016, Helper NLR proteins NRC2a/b and NRC3 but not NRC1 are required for Pto-mediated cell death and resistance in Nicotiana benthamiana, NEW PHYTOLOGIST, Vol: 209, Pages: 1344-1352, ISSN: 0028-646X Bozkurt TO, Belhaj K, Dagdas YF, Chaparro-Garcia A, Wu C-H, Cano LM, Kamoun Set al., 2015, Rerouting of Plant Late Endocytic Trafficking Toward a Pathogen Interface, TRAFFIC, Vol: 16, Pages: 204-226, ISSN: 1398-9219 Chaparro-Garcia A, Schwizer S, Sklenar J, Yoshida K, Petre B, Bos JIB, Schornack S, Jones AME, Bozkurt TO, Kamoun Set al., 2015, Phytophthora infestans RXLR-WY Effector AVR3a Associates with Dynamin-Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2, PLOS ONE, Vol: 10, ISSN: 1932-6203 Dagdas YF, Bozkurt TO, 2015, Fungal Sex Receptors Recalibrated to Detect Host Plants, CELL HOST & MICROBE, Vol: 18, Pages: 637-638, ISSN: 1931-3128 Giannakopoulou A, Steele JFC, Eugenia Segretin M, Bozkurt TO, Zhou J, Robatzek S, Banfield MJ, Pais M, Kamoun Set al., 2015, Tomato 12 Immune Receptor Can Be Engineered to Confer Partial Resistance to the Oomycete Phytophthora infestans in Addition to the Fungus Fusarium oxysporum, MOLECULAR PLANT-MICROBE INTERACTIONS, Vol: 28, Pages: 1316-1329, ISSN: 0894-0282 Ilyas M, Hoerger AC, Bozkurt TO, van den Burg HA, Kaschani F, Kaiser M, Belhaj K, Smoker M, Joosten MHAJ, Kamoun S, van der Hoorn RALet al., 2015, Functional Divergence of Two Secreted Immune Proteases of Tomato, CURRENT BIOLOGY, Vol: 25, Pages: 2300-2306, ISSN: 0960-9822 Oliva RF, Cano LM, Raffaele S, Win J, Bozkurt TO, Belhaj K, Oh S-K, Thines M, Kamoun Set al., 2015, A Recent Expansion of the RXLR Effector Gene Avrblb2 Is Maintained in Global Populations of Phytophthora infestans Indicating Different Contributions to Virulence, MOLECULAR PLANT-MICROBE INTERACTIONS, Vol: 28, Pages: 901-912, ISSN: 0894-0282 Bozkurt TO, Richardson A, Dagdas YF, Mongrand S, Kamoun S, Raffaele Set al., 2014, The Plant Membrane-Associated REMORIN1.3 Accumulates in Discrete Perihaustorial Domains and Enhances Susceptibility to Phytophthora infestans, PLANT PHYSIOLOGY, Vol: 165, Pages: 1005-1018, ISSN: 0032-0889 Dong S, Stam R, Cano LM, Song J, Sklenar J, Yoshida K, Bozkurt TO, Oliva R, Liu Z, Tian M, Win J, Banfield MJ, Jones AME, van der Hoorn RAL, Kamoun Set al., 2014, Effector Specialization in a Lineage of the Irish Potato Famine Pathogen, SCIENCE, Vol: 343, Pages: 552-555, ISSN: 0036-8075 Giannakopoulou A, Schornack S, Bozkurt TO, Haart D, Ro D-K, Faraldos JA, Kamoun S, O'Maille PEet al., 2014, Variation in Capsidiol Sensitivity between Phytophthora infestans and Phytophthora capsici Is Consistent with Their Host Range, PLOS ONE, Vol: 9, ISSN: 1932-6203 Bozkurt TO, Schornack S, Banfield MJ, Kamoun Set al., 2012, Oomycetes, effectors, and all that jazz, CURRENT OPINION IN PLANT BIOLOGY, Vol: 15, Pages: 483-492, ISSN: 1369-5266 Saunders DGO, Breen S, Win J, Schornack S, Hein I, Bozkurt TO, Champouret N, Vleeshouwers VGAA, Birch PRJ, Gilroy EM, Kamoun Set al., 2012, Host Protein BSL1 Associates with Phytophthora infestans RXLR Effector AVR2 and the Solanum demissum Immune Receptor R2 to Mediate Disease Resistance, PLANT CELL, Vol: 24, Pages: 3420-3434, ISSN: 1040-4651 van Damme M, Bozkurt TO, Cakir C, Schornack S, Sklenar J, Jones AME, Kamoun Set al., 2012, The Irish Potato Famine Pathogen Phytophthora infestans Translocates the CRN8 Kinase into Host Plant Cells, PLOS PATHOGENS, Vol: 8, ISSN: 1553-7374 Bozkurt TO, Schornack S, Win J, Shindo T, Ilyas M, Oliva R, Cano LM, Jones AME, Huitema E, van der Hoorn RAL, Kamoun Set al., 2011, Phytophthora infestans effector AVRblb2 prevents secretion of a plant immune protease at the haustorial interface, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 20832-20837, ISSN: 0027-8424 Oliva R, Win J, Raffaele S, Boutemy L, Bozkurt TO, Chaparro-Garcia A, Segretin ME, Stam R, Schornack S, Cano LM, van Damme M, Huitema E, Thines M, Banfield MJ, Kamoun Set al., 2010, Recent developments in effector biology of filamentous plant pathogens, CELLULAR MICROBIOLOGY, Vol: 12, Pages: 705-715, ISSN: 1462-5814 Oliva R, Win J, Raffaele S, Boutemy L, Bozkurt TO, Chaparro-Garcia A, Segretin ME, Stam R, Schornack S, Cano LM, van Damme M, Huitema E, Thines M, Banfield MJ, Kamoun Set al., 2010, Recent developments in effector biology of filamentous plant pathogens (vol 12, pg 705, 2010), CELLULAR MICROBIOLOGY, Vol: 12, Pages: 1015-1015, ISSN: 1462-5814 Schornack S, van Damme M, Bozkurt TO, Cano LM, Smoker M, Thines M, Gaulin E, Kamoun S, Huitema Eet al., 2010, Ancient class of translocated oomycete effectors targets the host nucleus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 17421-17426, ISSN: 0027-8424 Haas BJ, Kamoun S, Zody MC, Jiang RHY, Handsaker RE, Cano LM, Grabherr M, Kodira CD, Raffaele S, Torto-Alalibo T, Bozkurt TO, Ah-Fong AMV, Alvarado L, Anderson VL, Armstrong MR, Avrova A, Baxter L, Beynon J, Boevink PC, Bollmann SR, Bos JIB, Bulone V, Cai G, Cakir C, Carrington JC, Chawner M, Conti L, Costanzo S, Ewan R, Fahlgren N, Fischbach MA, Fugelstad J, Gilroy EM, Gnerre S, Green PJ, Grenville-Briggs LJ, Griffith J, Gruenwald NJ, Horn K, Horner NR, Hu C-H, Huitema E, Jeong D-H, Jones AME, Jones JDG, Jones RW, Karlsson EK, Kunjeti SG, Lamour K, Liu Z, Ma L, MacLean D, Chibucos MC, McDonald H, McWalters J, Meijer HJG, Morgan W, Morris PF, Munro CA, O'Neill K, Ospina-Giraldo M, Pinzon A, Pritchard L, Ramsahoye B, Ren Q, Restrepo S, Roy S, Sadanandom A, Savidor A, Schornack S, Schwartz DC, Schumann UD, Schwessinger B, Seyer L, Sharpe T, Silvar C, Song J, Studholme DJ, Sykes S, Thines M, van de Vondervoort PJI, Phuntumart V, Wawra S, Weide R, Win J, Young C, Zhou S, Fry W, Meyers BC, van West P, Ristaino J, Govers F, Birch PRJ, Whisson SC, Judelson HS, Nusbaum Cet al., 2009, Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans, NATURE, Vol: 461, Pages: 393-398, ISSN: 0028-0836