Williams, Huw - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

研究领域

We are focused on understanding the physiology of bacterial pathogens in relation to chronic infection. We study the mechanisms by which bacteria sense starvation stress, shut down metabolism and maintain cell integrity to enter into a persistent state within the context of chronic infections. We employ an eclectic mix of approaches including molecular genetics, mutational studies, transcriptomic and metabolomics approaches, targeted proteomics and flow cytometry as well as in vitro characterisation of proteins. Our research is in two main disease areas: 1. Tuberculosis. 2. Infections of the Cystic Fibrosis Lung

近期论文

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La Rosa R, Behrends V, Williams HD, Bundy JG, Rojo Fet al., 2016, Influence of the Crc regulator on the hierarchical use of carbon sources from a complete medium in Pseudomonas, ENVIRONMENTAL MICROBIOLOGY, Vol: 18, Pages: 807-818, ISSN: 1462-2912 Lund-Palau H, Turnbull AR, Bush A, Bardin E, Cameron L, Soren O, Wierre-Gore N, Alton EWFW, Bundy JG, Connett G, Faust SN, Filloux A, Freemont P, Jones A, Khoo V, Morales S, Murphy R, Pabary R, Simbo A, Schelenz S, Takats Z, Webb J, Williams HD, Davies JCet al., 2016, Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches, EXPERT REVIEW OF RESPIRATORY MEDICINE, Vol: 10, Pages: 685-697, ISSN: 1747-6348 Thompson AJ, Koziej L, Williams HD, Elson DS, Yang G-Zet al., 2016, Towards optical fibre based Raman spectroscopy for the detection of surgical site infection, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X Behrends V, Williams HD, Bundy JG, 2014, Metabolic footprinting: extracellular metabolomic analysis., Methods Mol Biol, Vol: 1149, Pages: 281-292 Frangipani E, Perez-Martinez I, Williams HD, Cherbuin G, Haas Det al., 2014, A novel cyanide-inducible gene cluster helps protect Pseudomonas aeruginosa from cyanide, ENVIRONMENTAL MICROBIOLOGY REPORTS, Vol: 6, Pages: 28-34, ISSN: 1758-2229 Lougheed KEA, Bennett MH, Williams HD, 2014, An in vivo crosslinking system for identifying mycobacterial protein-protein interactions, JOURNAL OF MICROBIOLOGICAL METHODS, Vol: 105, Pages: 67-71, ISSN: 0167-7012 Nair C, Shoemark A, Chan M, Ollosson S, Dixon M, Hogg C, Alton EWFW, Davies JC, Williams HDet al., 2014, Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary function, European Respiratory Journal, ISSN: 0903-1936 Nair CG, Ryall B, Williams HD, 2014, Cyanide measurements in bacterial culture and sputum., Methods Mol Biol, Vol: 1149, Pages: 325-336 Ryall B, Carrara M, Zlosnik JEA, Behrends V, Lee X, Wong Z, Lougheed KE, Williams HDet al., 2014, The Mucoid Switch in Pseudomonas aeruginosa Represses Quorum Sensing Systems and Leads to Complex Changes to Stationary Phase Virulence Factor Regulation, PLOS ONE, Vol: 9, ISSN: 1932-6203 Behrends V, Bell TJ, Liebeke M, Cordes-Blauert A, Ashraf SN, Nair C, Zlosnik JEA, Williams HD, Bundy JGet al., 2013, Metabolite Profiling to Characterize Disease-related Bacteria GLUCONATE EXCRETION BY PSEUDOMONAS AERUGINOSA MUTANTS AND CLINICAL ISOLATES FROM CYSTIC FIBROSIS PATIENTS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 15098-15109, ISSN: 0021-9258 Behrends V, Geier B, Williams HD, Bundy JGet al., 2013, Direct Assessment of Metabolite Utilization by Pseudomonas aeruginosa during Growth on Artificial Sputum Medium, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol: 79, Pages: 2467-2470, ISSN: 0099-2240 Behrends V, Ryall B, Zlosnik JEA, Speert DP, Bundy JG, Williams HDet al., 2013, Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections, ENVIRONMENTAL MICROBIOLOGY, Vol: 15, Pages: 398-408, ISSN: 1462-2912 Nair CG, Chao C, Ryall B, Williams HDet al., 2013, Sub-lethal concentrations of antibiotics increase mutation frequency in the cystic fibrosis pathogen Pseudomonas aeruginosa, LETTERS IN APPLIED MICROBIOLOGY, Vol: 56, Pages: 149-154, ISSN: 0266-8254 Behrends V, Ryall B, Zlosnik JEA, Speert DA, Williams HD, Bundy JGet al., 2012, Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis lung infections, INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, Vol: 302, Pages: 109-109, ISSN: 1438-4221 Nair C, Shoemark A, Donovan S, Hogg C, Alton EW, Davies JC, Williams HDet al., 2012, THE TOXIC P. AERUGINOSA EXOPRODUCTS CYANIDE AND PYOCYANIN INHIBIT CILIARY FUNCTION OF HUMAN RESPIRATORY EPITHELIA VIA DIFFERENT MECHANISMS, Publisher: WILEY-BLACKWELL, Pages: 329-329, ISSN: 8755-6863 Trauner A, Lougheed KEA, Bennett MH, Hingley-Wilson SM, Williams HDet al., 2012, The Dormancy Regulator DosR Controls Ribosome Stability in Hypoxic Mycobacteria, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 287, Pages: 24053-24063, ISSN: 0021-9258 Williams HD, Davies JC, 2012, Basic science for the chest physician: Pseudomonas aeruginosa and the cystic fibrosis airway, THORAX, Vol: 67, Pages: 465-467, ISSN: 0040-6376 Behrends V, Bundy JG, Williams HD, 2011, Differences in strategies to combat osmotic stress in Burkholderia cenocepacia elucidated by NMR-based metabolic profiling, LETTERS IN APPLIED MICROBIOLOGY, Vol: 52, Pages: 619-625, ISSN: 0266-8254 Nair CG, Shoemark A, Donovan S, Hogg C, Alton EW, Williams HD, Davies JCet al., 2011, POISON IN THE LUNG - CYANIDE, AT CONCENTRATIONS FOUND IN THE SPUTUM OF PSEUDOMONAS AERUGINOSA INFECTED CF PATIENTS INHIBITS THE BEATING OF HUMAN RESPIRATORY CILIA IN VITRO, Publisher: WILEY-BLACKWELL, Pages: 319-319, ISSN: 8755-6863 Trauner A, Bennett MH, Williams HD, 2011, Isolation of Bacterial Ribosomes with Monolith Chromatography, PLOS ONE, Vol: 6, ISSN: 1932-6203